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We identified 126 QTL for 96 traits on 19 of the 20 autosomal chromosomes of the female progeny. Four chromosomes (3, 6, 7, and 11) were identified as especially important in regulation of arterial pressure and renal function, since aggregates of 8\u201311 QTL mapped together on these chromosomes. BP QTL in this female population differed considerably from those previously found in male, other female, or mixed sex population linkage analysis studies using SS rats. Kidney weight divided by body weight was identified as an intermediate phenotype that mapped to the same region of the genome as resting diastolic blood pressure and was correlated with that same BP phenotype. Seven other phenotypes were considered as \u201cpotential intermediate phenotypes, \u201d which mapped to the same region of the genome as a BP QTL but were not correlated with BP. These included renal vascular responses to ANG II and ACh and indices of baroreceptor responsiveness. Secondary traits were also identified that were likely to be consequences of hypertension (correlated with BP but not mapped to a BP QTL). Seven such traits were found, notably heart rate, plasma cholesterol, and renal glomerular injury. The development of a female rat systems biology map of cardiovascular function represents the first attempt to prioritize those regions of the genome important for development of hypertension and end organ damage in female rats.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00105.2003","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:55:30Z","timestamp":1425416130000},"page":"243-257","source":"Crossref","is-referenced-by-count":79,"title":["Genomic map of cardiovascular phenotypes of hypertension in female Dahl S rats"],"prefix":"10.1152","volume":"15","author":[{"given":"Carol","family":"Moreno","sequence":"first","affiliation":[{"name":"Department of Physiology"},{"name":"Human and Molecular Genetics Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Dumas","sequence":"additional","affiliation":[{"name":"Department of Physiology"},{"name":"Human and Molecular Genetics 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