{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T16:24:00Z","timestamp":1715963040020},"reference-count":101,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2013,1,15]]},"abstract":"<jats:p>Menopausal hormone treatment (MHT) may limit progression of cardiovascular disease (CVD) but poses a thrombosis risk. To test targeted candidate gene variation for association with subclinical CVD defined by carotid artery intima-media thickness (CIMT) and coronary artery calcification (CAC), 610 women participating in the Kronos Early Estrogen Prevention Study (KEEPS), a clinical trial of MHT to prevent progression of CVD, were genotyped for 13,229 single nucleotide polymorphisms (SNPs) within 764 genes from anticoagulant, procoagulant, fibrinolytic, or innate immunity pathways. According to linear regression, proportion of European ancestry correlated negatively, but age at enrollment and pulse pressure correlated positively with CIMT. Adjusting for these variables, two SNPs, one on chromosome 2 for MAP4K4 gene (rs2236935, \u03b2 = 0.037, P value = 2.36 \u00d7 10<jats:sup>\u221206<\/jats:sup>) and one on chromosome 5 for IL5 gene (rs739318, \u03b2 = 0.051, P value = 5.02 \u00d7 10<jats:sup>\u221205<\/jats:sup>), associated positively with CIMT; two SNPs on chromosome 17 for CCL5 (rs4796119, \u03b2 = \u22120.043, P value = 3.59 \u00d7 10<jats:sup>\u221205<\/jats:sup>; rs2291299, \u03b2 = \u22120.032, P value = 5.59 \u00d7 10<jats:sup>\u221205<\/jats:sup>) correlated negatively with CIMT; only rs2236935 remained significant after correcting for multiple testing. Using logistic regression, when we adjusted for waist circumference, two SNPs (rs11465886, IRAK2, chromosome 3, OR = 3.91, P value = 1.10 \u00d7 10<jats:sup>\u221204<\/jats:sup>; and rs17751769, SERPINA1, chromosome 14, OR = 1.96, P value = 2.42 \u00d7 10<jats:sup>\u221204<\/jats:sup>) associated positively with a CAC score of &gt;0 Agatston unit; one SNP (rs630014, ABO, OR = 0.51, P value = 2.51 \u00d7 10<jats:sup>\u221204<\/jats:sup>) associated negatively; none remained significant after correcting for multiple testing. Whether these SNPs associate with CIMT and CAC in women randomized to MHT remains to be determined.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00114.2012","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T04:21:37Z","timestamp":1354076497000},"page":"79-88","source":"Crossref","is-referenced-by-count":27,"title":["Genetic polymorphisms associated with carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study"],"prefix":"10.1152","volume":"45","author":[{"given":"Virginia M.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Surgery, Mayo Clinic, Rochester, Minnesota;"},{"name":"Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanya M.","family":"Petterson","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elysia N.","family":"Jeavons","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abhinita S.","family":"Lnu","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David N.","family":"Rider","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Heit","sequence":"additional","affiliation":[{"name":"Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie M.","family":"Cunningham","sequence":"additional","affiliation":[{"name":"Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon S.","family":"Huggins","sequence":"additional","affiliation":[{"name":"MCRI Center for Translational Genomics, Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Howard N.","family":"Hodis","sequence":"additional","affiliation":[{"name":"Atherosclerosis Research Unit, Departments of Medicine and Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew J.","family":"Budoff","sequence":"additional","affiliation":[{"name":"Los Angeles Biomedical Research Institute, Torrance, California;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanette","family":"Santoro","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Colorado at Denver, Aurora, Colorado;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul N.","family":"Hopkins","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics, University of Utah, Salt Lake City, Utah;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogerio A.","family":"Lobo","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JoAnn E.","family":"Manson","sequence":"additional","affiliation":[{"name":"Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Naftolin","sequence":"additional","affiliation":[{"name":"Interdisciplinary Program in Menopausal Medicine, New York University, New York, New York;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh S.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Yale University, New Haven, Connecticut; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Mitchell","family":"Harman","sequence":"additional","affiliation":[{"name":"Kronos Longevity Research Institute, Phoenix, Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariza","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/S0303-7207(01)00552-4"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100155"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000101191.92392.1D"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07813-3"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1991.03460140089033"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.7.847"},{"key":"B7","first-page":"33","volume":"143","author":"Bass KM","year":"1991","journal-title":"J La State Med Soc"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00297-2"},{"key":"B9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5858\/2001-125-0112-TPAPOG","volume":"125","author":"Boudoulas KD","year":"2001","journal-title":"Arch Pathol Lab Med"},{"key":"B10","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1182\/blood.V73.3.712.712","volume":"73","author":"Bovill E","year":"1989","journal-title":"Blood"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.121.3.906"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.2005.14.410"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03330310033022"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61453-0"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000113291.39267.0a"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M012963"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.3.8354"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)03541-8"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0210073"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/0091-7435(88)90064-3"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.04.019"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.4.1228"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.12.038"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1086\/522239"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1080\/13547500410001720758"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1002\/0471142905.hg0117s74"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1080\/13697130500042417"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1086\/301947"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2012.04810.x"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04272.x"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.91.6.2776"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000018301.91721.94"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-135-11-200112040-00005"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2011.10.036"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-011-9296-9"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00193.2008"},{"key":"B37","first-page":"851","volume":"116","author":"Juul K","year":"2004","journal-title":"Ann Intern Med"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1738"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/01.GME.0000153934.76086.A4"},{"key":"B40","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1182\/blood.V84.4.1031.1031","volume":"84","author":"Koeleman B","year":"1994","journal-title":"Blood"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1898"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-1497"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.708016"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7256.273"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1000033"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1055\/s-0037-1613608"},{"key":"B47","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1182\/blood.V95.5.1517.005k48_1517_1532","volume":"95","author":"Lane DA","year":"2000","journal-title":"Blood"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/3.2.146"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1710417"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1038\/nature01323"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.09.009"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(01)01829-5"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.86.8.7768"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvp350"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806183382502"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.29.8.1525"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2004.08.027"},{"key":"B58","first-page":"370","volume":"125","author":"Mehta JL","year":"1995","journal-title":"J Lab Clin Med"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198710153171604"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-009-9104-y"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1124\/pr.107.08002"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.3109\/13697130902943287"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2005.01.040"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.073"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.050580997"},{"key":"B66","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/genetics\/155.2.945","volume":"155","author":"Pritchard JK","year":"2000","journal-title":"Genetics"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/S0076-6879(96)69012-0"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00689.x"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0b013e31823ac046"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(02)07779-6"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1161\/hq0202.102318"},{"key":"B73","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1182\/blood.V85.6.1504.bloodjournal8561504","volume":"85","author":"Rosendaal FR","year":"1995","journal-title":"Blood"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1046\/j.0007-1048.2002.03356.x"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.004043"},{"key":"B75a","doi-asserted-by":"publisher","DOI":"10.1001\/jama.288.3.321"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90176-7"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.17.11.3071"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)14066-4"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.0020143"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198403013100904"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(94)90186-4"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjhyper.2006.10.001"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1086\/316903"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.101.13.1546"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.07.002"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2005-0591"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.07.008"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2006.07.012"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.15.12.2085"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.96.10.3774"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-005-1258-3"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.961342"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1650289"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)90286-0"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00156-6"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000155746.65185.4e"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCGENETICS.111.961763"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3109\/08037059409102274"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2008.03243.x"},{"key":"B100","doi-asserted-by":"crossref","first-page":"3518","DOI":"10.1182\/blood.V85.12.3518.bloodjournal85123518","volume":"85","author":"Zoller B","year":"1995","journal-title":"Blood"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00114.2012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T12:50:20Z","timestamp":1643719820000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiolgenomics.00114.2012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1,15]]},"references-count":101,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2013,1,15]]}},"alternative-id":["10.1152\/physiolgenomics.00114.2012"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00114.2012","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,1,15]]}}}