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Genes required for efficient, fatigue-resistant, oxidative metabolism were increased in EOM, whereas genes for glycogen metabolism were decreased. EOM also showed increased expression of genes related to structural components of EOM such as vessels, nerves, mitochondria, and neuromuscular junctions. Additionally, genes related to specialized functional roles of EOM such as the embryonic and EOM-specific myosin heavy chains and genes for muscle growth, development, and\/or regeneration were increased. The EOM expression profile was validated using biochemical, structural, and molecular methods. Characterization of the EOM expression profile begins to define gene transcription patterns associated with the unique anatomical, metabolic, and pathophysiological properties of EOM.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00115.2001","type":"journal-article","created":{"date-parts":[[2015,3,3]],"date-time":"2015-03-03T20:57:05Z","timestamp":1425416225000},"page":"71-84","source":"Crossref","is-referenced-by-count":85,"title":["Expression profiling reveals metabolic and structural components of extraocular muscles"],"prefix":"10.1152","volume":"9","author":[{"given":"M. Dominik","family":"Fischer","sequence":"first","affiliation":[{"name":"Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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