{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:52:38Z","timestamp":1790607158568,"version":"4.1.0"},"reference-count":72,"publisher":"American Physiological Society","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2012,4,1]]},"abstract":"<jats:p>The present study was aimed at determining the consequences of the disruption of guanylyl cyclase\/natriuretic peptide receptor-A (GC-A\/NPRA) gene ( Npr1) on proinflammatory responses of nuclear factor kappa B, inhibitory kappa B kinase, and inhibitory kappa B alpha (NF-\u03baB, IKK, I\u03baB\u03b1) in the kidneys of mutant mice. The results showed that the disruption of Npr1 enhanced the renal NF-\u03baB binding activity by 3.8-fold in 0-copy (\u2212\/\u2212) mice compared with 2-copy (+\/+) mice. In parallel, IKK activity and I\u03baB\u03b1 protein phosphorylation were increased by 8- and 11-fold, respectively, in the kidneys of 0-copy mice compared with wild-type mice. Interestingly, I\u03baB\u03b1 was reduced by 80% and the expression of proinflammatory cytokines and renal fibrosis were significantly enhanced in 0-copy mice than 2-copy mice. Treatment of 0-copy mice with NF-\u03baB inhibitors andrographolide, pyrrolidine dithiocarbamate, and etanercept showed a substantial reduction in renal fibrosis, attenuation of proinflammatory cytokines gene expression, and significantly reduced IKK activity and IkB\u03b1 phosphorylation. These findings indicate that the systemic disruption of Npr1 activates the renal NF-\u03baB pathways in 0-copy mice, which transactivates the expression of various proinflammatory cytokines to initiate renal remodeling; however, inhibition of NF-\u03baB pathway repairs the abnormal renal pathology in mutant mice.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00147.2011","type":"journal-article","created":{"date-parts":[[2012,2,8]],"date-time":"2012-02-08T07:57:49Z","timestamp":1328687869000},"page":"430-442","source":"Crossref","is-referenced-by-count":32,"title":["Activation of IKK\/NF-\u03baB provokes renal inflammatory responses in guanylyl cyclase\/natriuretic peptide receptor-A gene-knockout mice"],"prefix":"10.1152","volume":"44","author":[{"given":"Subhankar","family":"Das","sequence":"first","affiliation":[{"name":"Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramu","family":"Periyasamy","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kailash N.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Physiology, Tulane University Health Sciences Center, School of Medicine, New Orleans, Louisiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009428"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.15.10925"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.19.13594"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1101\/gad.3.11.1689"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81318-5"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.14.1.649"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.17.1.f132"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1021\/jf104003y"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1021\/jf903629j"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-009-9409-z"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.2932797"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1139\/y01-038"},{"key":"B13","unstructured":"Dent CL , Smith MD , Latchman DS.Transcription Factors: A Practical Approach, edited by , Latchman DS. 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