{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T14:19:35Z","timestamp":1790000375113,"version":"4.0.1"},"reference-count":137,"publisher":"American Physiological Society","issue":"9","funder":[{"DOI":"10.13039\/100000057","name":"HHS | NIH | National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["131800"],"award-info":[{"award-number":["131800"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["109714"],"award-info":[{"award-number":["109714"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:p>This study provides a mechanistic modeling framework linking dietary protein quality, EAA-sensitive mTORC1\/GCN2-ISR signaling, peripheral circadian entrainment, and ribosome biogenesis, highlighting how nutrient stress may shape individualized circadian recovery and metabolic regulation.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00152.2026","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:04:11Z","timestamp":1787763851000},"page":"473-492","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Mathematical modeling of dietary timing- and protein quality-responsive liver circadian clock and its function on ribosome biogenesis"],"prefix":"10.1152","volume":"58","author":[{"given":"Lingjun","family":"Lu","sequence":"first","affiliation":[{"name":"Rutgers University\u2013New Brunswick","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-2433","authenticated-orcid":false,"given":"Jordan L.","family":"Levy","sequence":"additional","affiliation":[{"name":"Rutgers University\u2013New Brunswick","place":["United States"]},{"name":"Rutgers University\u2013New Brunswick","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8586-5884","authenticated-orcid":false,"given":"Tracy G.","family":"Anthony","sequence":"additional","affiliation":[{"name":"Rutgers University\u2013New Brunswick","place":["United States"]},{"name":"Rutgers University\u2013New Brunswick","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3795-3628","authenticated-orcid":false,"given":"Ioannis P.","family":"Androulakis","sequence":"additional","affiliation":[{"name":"Rutgers University\u2013New Brunswick","place":["United States"]},{"name":"Rutgers University\u2013New Brunswick","place":["United States"]},{"name":"Rutgers University\u2013New Brunswick","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.148.3676.1427"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.17.450"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5466.682"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1101\/gad.183500"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81199-x"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1037\/a0035942"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-024-00802-3"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14216"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2009.00665.x"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00114-013-1026-5"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56323-z"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1080\/07420520500545979"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124543"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.127234.1"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1519807112"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1519735112"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-021-00395-7"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2022.06.010"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-12-79"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1159\/000497354"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75245-9"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070813"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/93.20.1557"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-003-0440-y"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.926988"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2011.06.004"},{"key":"B27","first-page":"31","volume":"19","author":"Magrini A","year":"2006","journal-title":"Int J Immunopathol Pharmacol"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-2485"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/kqr001"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2012.03.038"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz204"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.13380"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1177\/0748730417713572"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1038\/srep05782"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103309"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201800078"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1101\/gr.222430.117"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-060909-153128"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.647"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.040824"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2011.01.006"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909591106"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.960351"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5488.2344"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5503.490"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1408886111"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.064"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201900158"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abi7828"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba8984"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.0050034"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00322.2014"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201500026"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa026"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2015803118"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-023-04834-4"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmac015"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101393"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01719"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat5314"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.19.6681-6688.2002"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.01.042"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)00028-9"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-012-1252-6"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(03)00105-9"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.85241"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1105\/tpc.19.00751"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2020.00431"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.08.007"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00129.2024"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1093\/jb\/mvaa061"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123757"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab362"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-021-00411-4"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1126\/science.aad0489"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63326"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.06.022"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.04.042"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1101\/gad.269324.115"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2018.00367"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1007369"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.04.002"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1001455"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1002\/med.21327"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbae023"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-016-1104-z"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-021-00728-8"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-022-02120-8"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2017.11.002"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2020.110360"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114482"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2020.00039"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26294-9"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.76188"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2017.06.013"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00006.2016"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00001.2012"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.18632\/aging.101721"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA117.001625"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-30979-0"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.12.173"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1210\/en.2011-1794"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.12.006"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2015.12.006"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.3389\/fnetp.2021.732243"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642195"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-13-3156"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12239"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.30802\/AALAS-CM-17-000107"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-05347-3"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-1051"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.11.061"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1177\/1177625017702393"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-20-0124"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000352"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100633"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32326-9"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1007330"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200204RR"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3945\/jn.116.246710"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.044"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.2337\/db15-1324"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-022-02983-z"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101309"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.3390\/nu9111176"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gms108"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21239220"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00706-1"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.3390\/muscles3010008"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E13-06-0353"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3283406f3e"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115074"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.090501.142857"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.08.022"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1126\/science.1195027"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1002\/oby.22773"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2017.03.008"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00152.2026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T13:41:38Z","timestamp":1789998098000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00152.2026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,1]]},"references-count":137,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9,1]]}},"alternative-id":["10.1152\/physiolgenomics.00152.2026"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00152.2026","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,1]]},"assertion":[{"value":"2026-04-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}