{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:49:27Z","timestamp":1787017767360,"version":"build-2736575974"},"reference-count":49,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01BX004288"],"award-info":[{"award-number":["I01BX004288"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH2010196\/PR191304"],"award-info":[{"award-number":["W81XWH2010196\/PR191304"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["20CDA35320169"],"award-info":[{"award-number":["20CDA35320169"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K01DK121737"],"award-info":[{"award-number":["K01DK121737"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002028","name":"Collins Medical Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["TL1TR002371"],"award-info":[{"award-number":["TL1TR002371"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"HHS | NIH | National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["KL2TR002370"],"award-info":[{"award-number":["KL2TR002370"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["24CDA1269598"],"award-info":[{"award-number":["24CDA1269598"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:p>Cardiac dysfunction is a common cause of acute kidney injury in a malady called acute cardiorenal syndrome. In a mouse model of acute cardiorenal syndrome called cardiac arrest\/cardiopulmonary resuscitation, we characterized, for the first time, the kidney transcriptional landscape at the single-cell level. We developed a novel method for quantifying cell response to injury and found that cells adapted through dedifferentiation, the magnitude of which varied depending on cell type.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00161.2024","type":"journal-article","created":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T10:35:03Z","timestamp":1740134103000},"page":"266-278","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Kidney cell response to acute cardiorenal and isolated kidney ischemia-reperfusion injury"],"prefix":"10.1152","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-6753","authenticated-orcid":false,"given":"Kevin G.","family":"Burfeind","sequence":"first","affiliation":[{"name":"Oregon Health & Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3609-0266","authenticated-orcid":false,"given":"Yoshio","family":"Funahashi","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8121-8105","authenticated-orcid":false,"given":"Xiao-Tong","family":"Su","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"Lackey","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9812-2262","authenticated-orcid":false,"given":"Matt W.","family":"Hagen","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sienna","family":"Blanche","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of University of Southern California","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline M.","family":"Emathinger","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica F.","family":"Hebert","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0459-469X","authenticated-orcid":false,"given":"Alicia A.","family":"McDonough","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of University of Southern California","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2659-6485","authenticated-orcid":false,"given":"Susan B.","family":"Gurley","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of University of Southern California","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1456-9399","authenticated-orcid":false,"given":"Jonathan W.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Keck School of Medicine of University of Southern California","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8583-1812","authenticated-orcid":false,"given":"Michael P.","family":"Hutchens","sequence":"additional","affiliation":[{"name":"Oregon Health & Science University","place":["United States"]},{"name":"Oregon Health & Science University","place":["United States"]},{"name":"Portland Veterans Administration Medical Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1097\/00005650-200006001-00004"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0900-2"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069998"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1159\/000313745"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2014.09.008"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1186\/cc9960"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00539-2"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.15173"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e3181c98da9"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5599"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.34067\/KID.0000000000000305"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2020.09.011"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2005477117"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05769-3"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122130"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2019.06.022"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.14670\/HH-18-012"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00573.2016"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1049-8"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1089\/ther.2014.0003"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1177\/1944451612461526"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00354.2011"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.3791\/3116"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.resuscitation.2007.06.031"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1093\/gigascience\/giaa151"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2019.03.003"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1404-z"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.04.048"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.05.031"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-052521-121841"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-023-01767-y"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-24277-4"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2011.0118"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00433.x"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00164.2016"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31772-9"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-024-01802-x"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-022-01108-9"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32634-0"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2021040439"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02441-2018"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125519"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.08.018"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.034"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406023302207"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00420.2010"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1172\/JCI158096"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btab209"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00161.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T12:53:02Z","timestamp":1743166382000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00161.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":49,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,1]]}},"alternative-id":["10.1152\/physiolgenomics.00161.2024"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00161.2024","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,1]]},"assertion":[{"value":"2024-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-29","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}