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We identified 59, 89, 53, 23, and 71 genes in bovine amygdala, dorsal hypothalamus, hippocampus, pituitary, and ventral hypothalamus, respectively, potentially involved in processes underlying estrus and estrous behavior. Functional annotation of the candidate genes points to a number of tissue-specific processes of which the \u201cneurotransmitter\/ion channel\/synapse\u201d process in the amygdala, \u201csteroid hormone receptor activity\/ion binding\u201d in the pituitary, \u201cextracellular region\u201d in the ventral hypothalamus, and \u201cpositive regulation of transcription\/metabolic process\u201d in the dorsal hypothalamus are most prominent. The regulation of the functional processes in the various tissues operate at different biological levels, including transcriptional, posttranscriptional, extracellular, and intercellular signaling levels.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00172.2012","type":"journal-article","created":{"date-parts":[[2013,4,10]],"date-time":"2013-04-10T06:03:43Z","timestamp":1365573823000},"page":"400-406","source":"Crossref","is-referenced-by-count":8,"title":["Prioritization of candidate genes for cattle reproductive traits, based on protein-protein interactions, gene expression, and text-mining"],"prefix":"10.1152","volume":"45","author":[{"given":"Ina","family":"Hulsegge","sequence":"first","affiliation":[{"name":"Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, Lelystad, The Netherlands; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henri","family":"Woelders","sequence":"additional","affiliation":[{"name":"Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, Lelystad, The Netherlands; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari","family":"Smits","sequence":"additional","affiliation":[{"name":"Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, Lelystad, The Netherlands; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirkjan","family":"Schokker","sequence":"additional","affiliation":[{"name":"Animal Breeding and Genomics Centre, Wageningen UR Livestock Research, Lelystad, The Netherlands; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Center for Quantitative Genetics and Genomics, Tjele, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"S\u00f8rensen","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Genetics, Center for Quantitative Genetics and Genomics, Tjele, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","volume":"57","author":"Benjamini Y","year":"1995","journal-title":"J Roy Stat Soc B Meth"},{"key":"B2","first-page":"9","volume":"7","author":"Bertolin K","year":"2010","journal-title":"Anim Reprod"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1017\/S1751731109991169"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-10-73"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1017\/S175173110800236X"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0531.2008.01185.x"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(78)90028-4"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-4388(96)80076-6"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2004-5-10-r80"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2008.211"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1186\/gb-2007-8-9-r183"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.2527\/jas.2011-4251"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkn760"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00047.2011"},{"key":"B15","unstructured":"Kommadath A.Genomic Regulation of Oestrus Behaviour in Dairy Cows. 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