{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:12:27Z","timestamp":1789557147004,"version":"build-2803163510"},"reference-count":61,"publisher":"American Physiological Society","issue":"8","funder":[{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL128350"],"award-info":[{"award-number":["R01 HL128350"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01 HL151438"],"award-info":[{"award-number":["R01 HL151438"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:p> Our study identified significant variances in ECG phenotypes and arrhythmias segregation in BXD mice. A significant quantitative trait locus (QTL) on Chromosome (Chr) 3 in the mouse genome was associated with increased QTc and JT intervals in male BXD mice. A suggestive QTL on Chr 9 associated with QT and QTc intervals was determined in female BXD mice. We identified a strong candidate gene, Gon4l, that may underlie cardiac repolarization abnormalities such as long and short QT syndromes. <\/jats:p>","DOI":"10.1152\/physiolgenomics.00183.2024","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T12:28:19Z","timestamp":1747657699000},"page":"456-469","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic mapping of electrocardiographic parameters in BXD strains reveals Chromosome 3 loci to be associated with cardiac repolarization abnormalities"],"prefix":"10.1152","volume":"57","author":[{"given":"Buyan-Ochir","family":"Orgil","sequence":"first","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5952-5771","authenticated-orcid":false,"given":"Fuyi","family":"Xu","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Binzhou Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1642-2393","authenticated-orcid":false,"given":"Ning","family":"Li","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis","place":["United States"]},{"name":"Harbin Medical University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh K.","family":"Bajpai","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neely R.","family":"Alberson","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason N.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Gu","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Affiliated Hospital of Nantong University","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn T.","family":"Wetzel","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey A.","family":"Towbin","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis","place":["United States"]},{"name":"St. Jude Children\u2019s Research Hospital","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Lu","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6188-7176","authenticated-orcid":false,"given":"Enkhsaikhan","family":"Purevjav","sequence":"additional","affiliation":[{"name":"University of Tennessee Health Science Center","place":["United States"]},{"name":"Children\u2019s Foundation Research Institute, Le Bonheur Children\u2019s Hospital Memphis","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.310782"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1101\/gr.086660.108"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1038\/ng1518"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.08.012"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2156-5-7"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms10464"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0133132"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00120.2022"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2020.05.006"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2023.1089963"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241612759"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00066.2021"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v9.i4.320"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2019.09.019"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.02.049"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.02.045"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2023.1118585"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.313406"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-023-09977-0"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/nature10413"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6427-7_4"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.106.058537"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gku1026"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1038\/nature24643"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1510687"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.917730"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/s00399-018-0566-y"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000095027.28753.9D"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.304521"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2008.159558"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-03715-w"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2020.03.002"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.693262"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-013-1415-9"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.04.005"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00042.2007"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq274"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/j.cels.2020.08.005"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.772715"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1186\/s42826-021-00102-3"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1007\/s00360-014-0830-3"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1177\/0192623310382864"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.09.009"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00941.2007"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00041.2012"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-023-09995-y"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00712.2022"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3390\/genes15010053"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2010.03660.x"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00864.2013"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.133603"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2021.04.001"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.028976"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-024-01816-2"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.118.312037"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.09.065"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2021.03.010"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104793"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1177\/17562864221133163"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2017.12.018"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0622-0"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00183.2024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T12:16:19Z","timestamp":1754568979000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00183.2024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,1]]},"references-count":61,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8,1]]}},"alternative-id":["10.1152\/physiolgenomics.00183.2024"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00183.2024","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,1]]},"assertion":[{"value":"2024-11-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-14","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}