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This treatment affected normal rats differently from diabetic rats, as demonstrated by two-way ANOVA of the full array data. Diabetes altered the expression of 133 genes, and the expression of 30% of these genes dysregulated in diabetes was normalized by vanadyl sulfate treatment. For those genes, the ratio of expression in normal animals to the expression in diabetic animals showed a strong negative correlation with the ratio of expression in diabetic animals to the expression in diabetic animals treated with vanadyl sulfate ( P = \u22120.85). The genes identified belong to six major metabolic functional groups: lipid metabolism, oxidative stress, muscle structure, protein breakdown and biosynthesis, the complement system, and signal transduction. The identification of oxidative stress genes, coupled with the known oxidative chemistry of vanadium, implicates reactive oxygen species in the action of this class of compounds. These results imply that early transition metals or compounds formed from their chemical interactions with other metabolites may act as general transcription modulators, a role not usually associated with this class of compounds.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00196.2005","type":"journal-article","created":{"date-parts":[[2006,5,10]],"date-time":"2006-05-10T03:28:50Z","timestamp":1147231730000},"page":"192-201","source":"Crossref","is-referenced-by-count":41,"title":["Diabetes-altered gene expression in rat skeletal muscle corrected by oral administration of vanadyl sulfate"],"prefix":"10.1152","volume":"26","author":[{"given":"Gail R.","family":"Willsky","sequence":"first","affiliation":[{"name":"Department of Biochemistry, School of Medicine and Biomedical Sciences, The State University of New York (SUNY) at Buffalo, Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lai-Har","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine and Biomedical Sciences, The State University of New York (SUNY) at Buffalo, Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yulan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health and Health Professions, SUNY at Buffalo, Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel P.","family":"Gaile","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health and Health Professions, SUNY at Buffalo, Buffalo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihua","family":"Hu","sequence":"additional","affiliation":[{"name":"Center for Computational Research, Department of Biostatistics, Department of Medicine, SUNY at Buffalo, Buffalo, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debbie C.","family":"Crans","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Colorado State University, Fort Collins, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","unstructured":"Anderson RA.Chromium in the prevention and control of diabetes.Diabetes Metab26: 22\u201327, 2000."},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.252626999"},{"key":"R4","unstructured":"Battell ML, Yuen VG, and McNeill JH.Treatment of the BB rats with vanadyl sulfate.Pharmacol Commun1: 291\u2013301, 1992."},{"key":"R5","unstructured":"Benjamini Yand Hockberg Y.Controlling the false discovery rate: a practical and powerful approach to multiple testing.J R Statist Soc57: 289\u2013300, 1995."},{"key":"R6","unstructured":"Benson DA, Karsch-Mizrachi I, Lipman DJ, Ostell J, and Wheeler DL.GenBank: update.Nucleic Acids Res32: D23\u2013D26, 2004."},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1006\/excr.1998.4092"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.1.3"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/S0026-0495(96)90013-X"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.54.6.1615"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1021\/ic048331q"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1139\/y00-053"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2004.01.003"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117951"},{"key":"R15","doi-asserted-by":"crossref","unstructured":"Cusi K, Cukier S, DeFronzo RA, Torres M, Puchulu FM, and Redondo JC.Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes.J Clin Endocrinol Metab86: 1410\u20131417, 2001.","DOI":"10.1210\/jc.86.3.1410"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006808100755"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-004-1332-8"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.8.2348"},{"key":"R19","unstructured":"Field CJand Butler SC.The BB rat: a unique model of human type I diabetes. 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