{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T19:25:26Z","timestamp":1694633126270},"reference-count":46,"publisher":"American Physiological Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:p>The aim of this study was to investigate the genetic basis of congenital hydronephrosis (HN), a poorly defined pathological entity, with a rat model. The Brown Norway (BN) strain spontaneously presents a high incidence of apparently asymptomatic HN, whereas the LOU strain does not. A backcross was established between these two strains [BN \u00d7 (BN \u00d7 LOU)] and a genomewide scan was performed with 193 microsatellite markers on 121 males and 118 females of this population, which had been phenotyped and scored for HN severity (defined as degree of renal pelvic dilation), followed by linkage analysis with Mapmaker\/QTL software. Bilateral HN score was significantly linked to a locus on chromosome 6 ( Z scores 4.4 and 4.8 for all rats and for females, respectively). Suggestive loci were identified on chromosomes 2 (for only right-sided HN) and 4. This is the first study in rats to identify genetic loci for HN. Three candidate genes present in these loci were sequenced and insertions detected in Id2 and Agtr1b genes in BN, which did not, however, lead to modified expression as measured by quantitative PCR. Production of a congenic line for part of the chromosome 6 locus confirmed its involvement in HN, but the phenotype was mild. Evidence of hematuria was observed in 9.6% of the backcross rats, mostly males and only in kidneys with HN, but not necessarily in the most severely affected. Hematuria also occurs in the BN colony used here, where it is due to papilloma-like lesions involving pelvic epithelial proliferation, but not in the LOU rat.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00221.2007","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T03:09:26Z","timestamp":1212548966000},"page":"215-224","source":"Crossref","is-referenced-by-count":7,"title":["Localization of genetic loci controlling hydronephrosis in the Brown Norway rat and its association with hematuria"],"prefix":"10.1152","volume":"34","author":[{"given":"Lalitha","family":"Kota","sequence":"first","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herbert","family":"Schulz","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samreen","family":"Falak","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"H\u00fcbner","sequence":"additional","affiliation":[{"name":"Max Delbr\u00fcck Center for Molecular Medicine, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Osborne-Pellegrin","sequence":"additional","affiliation":[{"name":"Inserm, U698, H\u00f4pital Bichat, and Universit\u00e9 Paris 7, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2004.00805.x"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.11.002"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00544.2004"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2005.11.004"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90214-Y"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1203\/01.pdr.0000238243.37116.a6"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/52.3.1005"},{"key":"R8","unstructured":"Boorman GA, Burek JD, Hollander CF.Animal model: spontaneous urothelial tumors in BN\/BiRij rats.Am J Pathol88: 251\u2013254, 1977."},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1101\/gr.7.3.262"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcl.2006.02.012"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1979.72"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg062"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1038\/nbt821"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01332-06"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)42033-7"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.34.4.643"},{"key":"R17","doi-asserted-by":"publisher","DOI":"10.1038\/ng1522"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.39.355"},{"key":"R19","unstructured":"Koff SA.The beneficial and protective effects of hydronephrosis.APMIS Suppl109: 7\u201312, 2003."},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00209.2006"},{"key":"R21","doi-asserted-by":"crossref","unstructured":"Kruglyak L, Lander E.A nonparametric approach for mapping quantitative trait loci.Genetics139: 1421\u20131428, 1995.","DOI":"10.1093\/genetics\/139.3.1421"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(87)90010-3"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1038\/ng1195-241"},{"key":"R24","unstructured":"Laycock JF, Barrett MC, Woodrow DF.Hydronephrosis: prevention by restoration of urinary concentrating ability using desamino-8D-arginine vasopressin (DDVAP) in Brattleboro rats.Int J Exp Pathol72: 581\u2013587, 1991."},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609326103"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2003.07.019"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/S1095-6433(00)00299-3"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2006.07.020"},{"key":"R29","doi-asserted-by":"crossref","unstructured":"Norton JD, Deed RW, Craggs G, Sablitzky F.Id helix-loop-helix proteins in cell growth and differentiation.Trends Cell Biol8: 58\u201365, 1998.","DOI":"10.1016\/S0962-8924(98)80013-5"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(85)90039-5"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1002\/pd.211"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.3109\/00365599009180377"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37863-1"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2006.045013"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1007\/s002400050146"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2003.10.010"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(94)90027-2"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1038\/ng.124"},{"key":"R39","unstructured":"Tauchi K, Suzuki K, Imamichi T.Establishment of a strain of rat having extremely high incidence of congenital hydronephrosis and its morphological characteristics.Congenit Anom (Kyoto)20: 1\u20136, 1980."},{"key":"R40","unstructured":"Treloar AF, Armstrong A.Intermittent hematuria in a colony of Lewis \u00d7 Brown Norway hybrid rats.Lab Anim Sci43: 640\u2013641, 1993."},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1899"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.1159\/000187510"},{"key":"R43","doi-asserted-by":"crossref","unstructured":"Vari RC, Boineau FG, Lewy JE.Angiotensin or thromboxane receptor antagonism in rats with congenital hydronephrosis.J Am Soc Nephrol3: 1522\u20131529, 1993.","DOI":"10.1681\/ASN.V381522"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1038\/17812"},{"key":"R45","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205090"},{"key":"R46","doi-asserted-by":"publisher","DOI":"10.1046\/j.1442-2042.2002.00507.x"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00221.2007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,9,11]],"date-time":"2021-09-11T15:17:06Z","timestamp":1631373426000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiolgenomics.00221.2007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,7]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,7]]}},"alternative-id":["10.1152\/physiolgenomics.00221.2007"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00221.2007","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,7]]}}}