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Based upon coordinate regulation of morphologic\/gene expression traits with key events in visual, vestibular, and oculomotor system development, we propose a model that the EOM phenotype is a consequence of extrinsic factors that are unique to its local environment and sensory-motor control system, acting upon a novel myoblast lineage. We identified a broad spectrum of differences between the postnatal transcriptional patterns of EOM and limb muscle allotypes, including numerous transcripts not traditionally associated with muscle fiber\/group differences. Several transcription factors were differentially regulated and may be responsible for signaling muscle allotype specificity. Significant differences in cellular energetic mechanisms defined the EOM and limb allotypes. The allotypes were divergent in many other functional transcript classes that remain to be further explored. Taken together, we suggest that the EOM allotype is the consequence of tissue-specific mechanisms that direct expression of a limited number of EOM-specific transcripts and broader, incremental differences in transcripts that are conserved by the two allotypes. This represents an important first step in dissecting allotype-specific regulatory mechanisms that may, in turn, explain differential muscle group sensitivity to a variety of metabolic and neuromuscular diseases.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00222.2003","type":"journal-article","created":{"date-parts":[[2004,5,18]],"date-time":"2004-05-18T00:13:32Z","timestamp":1084839212000},"page":"184-195","source":"Crossref","is-referenced-by-count":31,"title":["Conserved and muscle-group-specific gene expression patterns shape postnatal development of the novel extraocular muscle phenotype"],"prefix":"10.1152","volume":"18","author":[{"given":"Georgiana","family":"Cheng","sequence":"first","affiliation":[{"name":"Department of Neurology, Cleveland, Ohio 44106"},{"name":"Department of Visual Sciences Research Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita P.","family":"Merriam","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cleveland, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bendi","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Visual Sciences Research Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Leahy","sequence":"additional","affiliation":[{"name":"Department of Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sangeeta","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cleveland, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Porter","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cleveland, Ohio 44106"},{"name":"Department of Neurosciences, Cleveland, Ohio 44106"},{"name":"Department of Visual Sciences Research Center, Ohio 44106"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00358.2003"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0029(20000201\/15)48:3\/4<192::AID-JEMT7>3.0.CO;2-J"},{"key":"R3","doi-asserted-by":"crossref","unstructured":"Briggs MM and Schachat F.Early specialization of the superfast myosin in extraocular and laryngeal muscles.J Exp Biol203: 2485\u20132494, 2000.","DOI":"10.1242\/jeb.203.16.2485"},{"key":"R4","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1970.00480280083010"},{"key":"R5","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051253"},{"key":"R6","doi-asserted-by":"publisher","DOI":"10.1007\/BF00240928"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1998.85.2.584"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1126\/science.174.4010.709"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.24.8490-8503.2001"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1038\/297504a0"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0170"},{"key":"R12","unstructured":"Cheng G and Porter JD.Transcriptional profile of rat extraocular muscle by serial analysis of gene expression.Invest Ophthalmol Vis Sci43: 1048\u20131058, 2002."},{"key":"R13","doi-asserted-by":"crossref","unstructured":"Couly GF, Coltey PM, and Le Douarin NM.The developmental fate of the cephalic mesoderm in quail-chick chimeras.Development114: 1\u201315, 1992.","DOI":"10.1242\/dev.114.1.1"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.0131"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1996.80.1.261"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1007\/s004410051278"},{"key":"R17","doi-asserted-by":"crossref","unstructured":"Dietrich S, Schubert FR, Healy C, Sharpe PT, and Lumsden A.Specification of the hypaxial musculature.Development125: 2235\u20132249, 1998.","DOI":"10.1242\/dev.125.12.2235"},{"key":"R18","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00115.2001"},{"key":"R19","doi-asserted-by":"crossref","unstructured":"Gage PJ, Suh H, and Camper SA.Dosage requirement of Pitx2 for development of multiple organs.Development126: 4643\u20134651, 1999.","DOI":"10.1242\/dev.126.20.4643"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1980.tb06500.x"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1016\/0305-0491(94)90003-5"},{"key":"R22","doi-asserted-by":"publisher","DOI":"10.1016\/S0300-9084(97)81509-X"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1007\/BF01682148"},{"key":"R24","unstructured":"Hoh JFY, Hughes S, Hugh G, and Pozgaj I.Three hierarchies in skeletal muscle fibre classification: allotype, isotype, and phenotype. 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