{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T15:06:47Z","timestamp":1790089607659,"version":"4.0.1"},"reference-count":164,"publisher":"American Physiological Society","issue":"10","funder":[{"DOI":"10.13039\/100011991","name":"National Search and Rescue Secretariat","doi-asserted-by":"publisher","award":["31234-094495\/A"],"award-info":[{"award-number":["31234-094495\/A"]}],"id":[{"id":"10.13039\/100011991","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["227912-07"],"award-info":[{"award-number":["227912-07"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012114","name":"Defence Research and Development Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012114","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2026,10,1]]},"abstract":"<jats:p>This first-in-human study provides a systems-level characterization of leukocyte transcriptomic responses to 24-h continuous cold exposure. Despite clear physiological strain, the blood transcriptome remains remarkably stable, with only transient, targeted immunometabolic shifts. These findings reveal energy-efficient molecular homeostasis during sustained cold stress and establish peripheral blood transcriptomics as a viable platform for monitoring human cold adaptation in real-world and operational environments.<\/jats:p>","DOI":"10.1152\/physiolgenomics.00337.2025","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T08:00:57Z","timestamp":1783584057000},"page":"525-542","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptomic profiling reveals immunometabolic gene regulation during a 24-h cold exposure survival simulation in humans"],"prefix":"10.1152","volume":"58","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6076-7321","authenticated-orcid":false,"given":"Jing","family":"Zhang","sequence":"first","affiliation":[{"name":"Toronto Research Centre","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2300-0620","authenticated-orcid":false,"given":"Shawn G.","family":"Rhind","sequence":"additional","affiliation":[{"name":"Toronto Research Centre","place":["Canada"]},{"name":"University of Toronto","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1474-2892","authenticated-orcid":false,"given":"Michel B.","family":"DuCharme","sequence":"additional","affiliation":[{"name":", Valcartier Research Centre","place":["Canada"]},{"name":"Marine and Arctic Survival Scientific and Engineering Research Team (MASSERT)","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Y.","family":"Shiu","sequence":"additional","affiliation":[{"name":"Toronto Research Centre","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glen A.","family":"Selkirk","sequence":"additional","affiliation":[{"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0436-048X","authenticated-orcid":false,"given":"Michael J.","family":"Taber","sequence":"additional","affiliation":[{"name":"Brock University","place":["Canada"]},{"name":"N2M Consulting Incorporated","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7454-7373","authenticated-orcid":false,"given":"Gregory Walter","family":"McGarr","sequence":"additional","affiliation":[{"name":"Brock University","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0759-5583","authenticated-orcid":false,"given":"Fabien A.","family":"Basset","sequence":"additional","affiliation":[{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3728-1665","authenticated-orcid":false,"given":"Fran\u00e7ois","family":"Haman","sequence":"additional","affiliation":[{"name":"N2M Consulting Incorporated","place":["Canada"]},{"name":"University of Ottawa","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-4978","authenticated-orcid":false,"given":"Stephen S.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Brock University","place":["Canada"]},{"name":"Marine and Arctic Survival Scientific and Engineering Research Team (MASSERT)","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.12.008"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-012420-105026"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-publhealth-060222-034131"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1093\/epirev\/mxf007"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1003198"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000165"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)62114-0"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.buildenv.2023.111127"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1136\/jech-2013-202449"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1307524"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2021"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-068183"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0000000000003560"},{"key":"B14","volume-title":"Canada\u2019s Arctic Foreign Policy","author":"Government of Canada","year":"2024"},{"key":"B15","unstructured":"Lackenbauer PW. Canada\u2019s Arctic foreign policy: key takeaways for Arctic security practitioners and scholars. NAADSN Policy Primer. Peterborough (ON): North American and Arctic Defence and Security Network; 2024. 1\u201321. https:\/\/www.naadsn.ca\/wp-content\/uploads\/2025\/01\/24dec-CAFP-Lackenbauer-NAADSN-Policy-Primer.pdf."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1002\/j.2040-4603.1994.tb01165.x"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2022.2044740"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1136\/jramc-157-01-14"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2016.02.009"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2017.1384091"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.17226\/5197"},{"key":"B22","first-page":"444","volume":"75","author":"Stocks JM","year":"2004","journal-title":"Aviat Space Environ Med"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2021.1903145"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1609348"},{"key":"B25","volume-title":"Homeostatic Responses to Prolonged Cold Exposure: Human Cold Acclimatization","author":"Young AJ","year":"1994"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00540.2015"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/8130731"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2022.12.006"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2024.2408059"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1042\/CS20170276"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177651"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-96-3009-7_5"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.4093\/dmj.2017.41.5.327"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2020.01.023"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41366-024-01522-6"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.20463\/jenb.2017.0020"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adt7369"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1348264"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.01.013"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-1244-1_9"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3390\/plants9050560"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-ento-120120-095233"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1093\/gbe\/evaf077"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2021.102933"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01143.2001"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00221.2015"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1186\/s40101-021-00267-9"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1016\/s0306-4522(99)00368-1"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.78556"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/s12010-011-9273-4"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068933"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.660402"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/proteomes12030025"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1016\/j.cois.2014.08.005"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.12.011"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1111\/1755-0998.13796"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00886.2003"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1171103"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2025.01.013"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1080\/02656730410001670651"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.2001.281.1.R66"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1080\/02699052.2017.1342000"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13534"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/28.1.27"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt111"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406811102"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-6-144"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1093\/biostatistics\/kxj009"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1214\/07-AOAS101"},{"key":"B73","volume-title":"gplots: Various R Programming Tools for Plotting Data","author":"Warnes GR","year":"2005"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1007\/978-0-387-98141-3"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt285"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/156.3.140"},{"key":"B77","first-page":"281","volume":"74","author":"Moran DS","year":"2003","journal-title":"Aviat Space Environ Med"},{"key":"B78","first-page":"680","volume":"100","author":"Rathjen NA","year":"2019","journal-title":"Am Fam Physician"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19010501"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.5.2084"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.2001.90.3.939"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1007\/BF01212587"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2004.01.004"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.2741\/s124"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2017.1328999"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.buildenv.2023.110664"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1080\/22423982.2023.2246666"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/usad451"},{"key":"B89","volume-title":"Nutritional Needs in Cold and in High-Altitude Environments Applications for Military Personnel in Field Operations (1996)","author":"Marriott BM","year":"1996"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1111\/obr.12978"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2025.2599582"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-023-09587-9"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-025-02141-x"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.09.002"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-024-02300-z"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1080\/23328940.2015.1135688"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1210\/js.2019-00309"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20190464"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2021.100427"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1186\/s40101-025-00391-w"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00204.2005"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00425.2017"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.3390\/cells8111373"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-08902-6"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.05.011"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-025-01458-5"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2016.223"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-004-1140-3"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2025.1539615"},{"key":"B110","first-page":"112","volume":"12","author":"Simon P","year":"2006","journal-title":"Exerc Immunol Rev"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2016.05.001"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1111\/jpn.14115"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1615\/critrevimmunol.v18.i6.40"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-76-9-828"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110774"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.2.699"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200212000-00023"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1097\/00005768-200301000-00026"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1080\/02656730410001670651"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165823"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.3390\/cells11111824"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3390\/healthcare13172244"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0403627101"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1160\/TH16-12-0931"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-56354-6"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.3390\/biom14080935"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1515\/enr-2016-0015"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-017-0531-z"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2025.123431"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202350897"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1186\/s40101-025-00387-6"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1113\/JP285269"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1592683"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1002\/cph4.70001"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2017.10.005"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23970"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnz007"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-022-00590-0"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-024-00536-8"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.588387"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12394"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtherbio.2022.103259"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2025.102102"},{"key":"B144","first-page":"544","volume":"73","author":"Castellani JW","year":"2002","journal-title":"Aviat Space Environ Med"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.2741\/s106"},{"key":"B146","volume-title":"StatPearls","author":"Osilla EV","year":"2026"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1152\/physiolgenomics.00296.2005"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-010-0181-2"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1139\/y00-124"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.19.030157.000423"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1960.198.2.375"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1960.15.4.659"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.40.3.455"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1983.54.4.1025"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1016\/j.lab.2005.10.005"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7007-8-84"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.03.002"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1982.53.3.610"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1007\/BF02189365"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.14430\/arctic1530"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1991.71.1.60"},{"key":"B162","first-page":"S9","volume":"54","author":"Reed HL","year":"1995","journal-title":"Arctic Med Res"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31750-1"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-025-09226-x"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.00337.2025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:49:33Z","timestamp":1790088573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physiolgenomics.00337.2025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":164,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,1]]}},"alternative-id":["10.1152\/physiolgenomics.00337.2025"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.00337.2025","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"assertion":[{"value":"2025-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-28","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}