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Because FPLD is an extreme example of genetically disturbed adipocyte differentiation, it is possible that common variation in LMNA is associated with obesity-related phenotypes. We therefore analyzed the relationships between the common LMNA 1908T\/C single nucleotide polymorphism (SNP) and plasma leptin and anthropometric indices in 306 nondiabetic Canadian Oji-Cree. We found that subjects with the LMNA 1908T\/1908T genotype had significantly higher plasma leptin than the subjects with either the 1908C\/1908T or 1908C\/1908C genotypes, after adjustment for age and sex. Physical indices of obesity, such as body mass index, percent body fat, and ratio of waist-to-hip circumference, were also higher among Oji-Cree subjects with the LMNA 1908T\/1908T genotype than the subjects with either the 1908C\/1908T or 1908C\/1908C genotypes. The results suggest that common genetic variation in LMNA may be an important determinant of plasma leptin and obesity-related quantitative traits.<\/jats:p>","DOI":"10.1152\/physiolgenomics.2000.3.1.39","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T22:55:45Z","timestamp":1514069745000},"page":"39-44","source":"Crossref","is-referenced-by-count":53,"title":["Genetic variation in<i>LMNA<\/i>modulates plasma leptin and indices of obesity in aboriginal Canadians"],"prefix":"10.1152","volume":"3","author":[{"given":"ROBERT A.","family":"HEGELE","sequence":"first","affiliation":[{"name":"John P. Robarts Research Institute"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"HENIAN","family":"CAO","sequence":"additional","affiliation":[{"name":"John P. 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