{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:24:50Z","timestamp":1788834290113,"version":"build-2803163510"},"reference-count":152,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2000,6,29]]},"abstract":"<jats:p>Melo, Luis G., Mark E. Steinhelper, Stephen C. Pang, Yat Tse, and Uwe Ackermann. ANP in the regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models. Physiol Genomics 3: 45\u201358, 2000.\u2014The recent development of genetic mouse models presenting life-long alterations in expression of the genes for atrial natriuretic peptide (ANP) or its receptors (NPR-A, NPR-C) has uncovered a physiological role of this hormone in chronic blood pressure homeostasis. Transgenic mice overexpressing a transthyretin-ANP fusion gene are hypotensive relative to the nontransgenic littermates, whereas mice harboring functional disruptions of the ANP or NPR-A genes are hypertensive compared with their respective wild-type counterparts. The chronic hypotensive action of ANP is determined by vasodilation of the resistance vasculature, which is probably mediated by attenuation of vascular sympathetic tone at one or several prejunctional sites. Under conditions of normal dietary salt consumption, the hypotensive action of ANP is dissociated from the natriuretic activity of the hormone. However, during elevated dietary salt intake, ANP-mediated antagonism of the renin-angiotensin system is essential for maintenance of blood pressure constancy, inasmuch as the ANP gene \u201cknockout\u201d mice (ANP \u2212\/\u2212) develop a salt-sensitive component of hypertension in association with failure to adequately downregulate plasma renin activity. These findings imply that genetic deficiencies in ANP or natriuretic receptor activity may be underlying causative factors in the etiology of salt-sensitive variants of hypertensive disease and other sodium-retaining disorders, such as congestive heart failure and cirrhosis.<\/jats:p>","DOI":"10.1152\/physiolgenomics.2000.3.1.45","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T22:55:45Z","timestamp":1514069745000},"page":"45-58","source":"Crossref","is-referenced-by-count":69,"title":["ANP in regulation of arterial pressure and fluid-electrolyte balance: lessons from genetic mouse models"],"prefix":"10.1152","volume":"3","author":[{"given":"LUIS G.","family":"MELO","sequence":"first","affiliation":[{"name":"Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8"},{"name":"Department of Medicine, Harvard Medical School and Brigham and Women\u2019s Hospital, Boston, Massachusetts 02115"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"MARK E.","family":"STEINHELPER","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78284"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"STEPHEN C.","family":"PANG","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Queen\u2019s University, Kingston, Ontario, Canada K7L 3N6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YAT","family":"TSE","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Cell Biology, Queen\u2019s University, Kingston, Ontario, Canada K7L 3N6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"UWE","family":"ACKERMANN","sequence":"additional","affiliation":[{"name":"Department of Physiology, University of Toronto, Toronto, Ontario, Canada M5S 1A8"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1139\/y84-135"},{"key":"R2","unstructured":"Ackermann U.Cardiovascular effects of atrial natriuretic extract in the whole animal.Fed Proc45: 2111\u20132114, 1986."},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(86)90351-6"},{"key":"R4","unstructured":"Almeida FA, Suzuki M, and Maack T.High salt intake increases the vasorelaxant effect of ANF on the isolated perfused rat kidney.Braz J Med Biol Res24: 1149\u20131157, 1991."},{"key":"R5","doi-asserted-by":"crossref","unstructured":"Anand-Srivastava MB and Trachte GJ.Atrial natriuretic factor receptors and signal transduction mechanisms.Pharmacol Rev45: 455\u2013497, 1993.","DOI":"10.1016\/S0031-6997(25)00429-6"},{"key":"R6","doi-asserted-by":"crossref","unstructured":"Anand-Srivastava MB, Sairam MR, and Cantin M.Ring-deleted analogs of atrial natriuretic factor inhibit adenylate cyclase\/cAMP system.J Biol Chem265: 8566\u20138572, 1990.","DOI":"10.1016\/S0021-9258(19)38925-2"},{"key":"R7","doi-asserted-by":"publisher","DOI":"10.1007\/BF02191911"},{"key":"R8","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.74.4.747"},{"key":"R9","doi-asserted-by":"publisher","DOI":"10.1016\/0196-9781(92)90026-Y"},{"key":"R10","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90694-8"},{"key":"R11","doi-asserted-by":"publisher","DOI":"10.1139\/y91-169"},{"key":"R12","doi-asserted-by":"publisher","DOI":"10.1042\/cs0830013"},{"key":"R13","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1995.269.1.H326"},{"key":"R14","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1990.70.3.665"},{"key":"R15","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1985.249.6.R776"},{"key":"R16","doi-asserted-by":"publisher","DOI":"10.1126\/science.2935937"},{"key":"R17","unstructured":"Burnstock G.Local mechanisms of blood flow control by perivascular nerves and endothelium.J Hypertens8,Suppl7: S95\u2013S106, 1990."},{"key":"R18","doi-asserted-by":"crossref","unstructured":"Cachofeiro V, Schiffrin EL, Thibault G, Cantin M, and Garcia R.Effect of chronic infusion of atrial natriuretic factor on glomerular and vascular receptors in spontaneously hypertensive rats.J Hypertens7: 335\u2013342, 1989.","DOI":"10.1097\/00004872-198904000-00015"},{"key":"R19","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.28.3.335"},{"key":"R20","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.25.2.227"},{"key":"R21","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1993.264.3.R533"},{"key":"R22","doi-asserted-by":"crossref","unstructured":"Cody RJ.The sympathetic nervous system and the renin-angiotensin-aldosterone system in cardiovascular disease.Am J Cardiol80,Suppl9B: 9J\u201314J, 1997.","DOI":"10.1016\/S0002-9149(97)00832-1"},{"key":"R23","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1986.250.1.F22"},{"key":"R24","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1992.72.1.231"},{"key":"R25","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(87)90613-6"},{"key":"R26","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(86)90559-0"},{"key":"R27","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(90)90347-7"},{"key":"R28","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-194-43087"},{"key":"R29","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.1.64"},{"key":"R30","doi-asserted-by":"publisher","DOI":"10.1038\/ng0792-267"},{"key":"R31","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1997.77.1.75"},{"key":"R32","doi-asserted-by":"publisher","DOI":"10.1210\/endo.134.1.8275937"},{"key":"R33","doi-asserted-by":"publisher","DOI":"10.1210\/endo.133.6.8243267"},{"key":"R34","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.3.2.2521610"},{"key":"R35","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.256.2.R577"},{"key":"R36","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1990.258.2.H419"},{"key":"R37","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.63.2.415"},{"key":"R38","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(85)90599-5"},{"key":"R39","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.7292"},{"key":"R40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.1.R1"},{"key":"R41","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1995.269.2.R406"},{"key":"R42","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-179-RC1AA"},{"key":"R43","doi-asserted-by":"crossref","unstructured":"Genain CP, Reddy SR, Ott CE, Van Loon GR, and Kotchen TA.Failure of salt loading to inhibit tissue norepinephrine turnover in prehypertensive Dahl salt-sensitive rats.Hypertension12: 568\u2013573. 1988.","DOI":"10.1161\/01.HYP.12.6.568"},{"key":"R44","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.15.1.9"},{"key":"R45","doi-asserted-by":"crossref","unstructured":"Granger JP, Opgenorth TJ, Salazar J, Romero JC, and Burnett JC, JR.Long-term hypotensive and renal effects of atrial natriuretic peptide.Hypertension8,SupplII: II-112\u2013II-116, 1986.","DOI":"10.1161\/01.HYP.8.6_Pt_2.II112"},{"key":"R46","doi-asserted-by":"crossref","unstructured":"Haass M, Kopin U, Goldstein DS, and Zukowska-Grojec Z.Differential inhibition of alpha adrenoceptor-mediated pressor responses by rat atrial natriuretic peptide in the pithed rat.J Pharmacol Exp Ther235: 122\u2013127, 1985.","DOI":"10.1016\/S0022-3565(25)23848-4"},{"key":"R47","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1985.248.5.F621"},{"key":"R48","doi-asserted-by":"publisher","DOI":"10.1038\/326697a0"},{"key":"R49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.1.R247"},{"key":"R50","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1985.248.4.H587"},{"key":"R51","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107748"},{"key":"R52","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.9.4.350"},{"key":"R53","doi-asserted-by":"publisher","DOI":"10.1042\/cs0870525"},{"key":"R54","doi-asserted-by":"publisher","DOI":"10.1139\/y99-043"},{"key":"R55","unstructured":"Hu RM, Levin ER, Pedram A, and Frank HJL.Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells: mediation through the C receptor.J Biol Chem267: 17384\u201317389, 1992."},{"key":"R56","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.60.2.304"},{"key":"R57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1987.252.5.R878"},{"key":"R58","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.57.030195.001131"},{"key":"R59","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114134"},{"key":"R60","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114893"},{"key":"R61","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.19.6.758"},{"key":"R62","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.15.2.170"},{"key":"R63","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.11.6.739"},{"key":"R64","doi-asserted-by":"publisher","DOI":"10.1126\/science.7839143"},{"key":"R65","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1996.271.1.R109"},{"key":"R66","doi-asserted-by":"crossref","unstructured":"Johnston CI, Hodsman PG, Kohzuki M, Casley DJ, Fabris B, and Phillips PA.Interaction between natriuretic peptide and the renin angiotensin aldosterone system.Am J Med87,Suppl6B: 24S\u201328S, 1989.","DOI":"10.1016\/S0002-9343(89)80924-6"},{"key":"R67","doi-asserted-by":"publisher","DOI":"10.1139\/y87-268"},{"key":"R68","doi-asserted-by":"crossref","unstructured":"Johnston CI.Biochemistry and pharmacology of the renin angiotensin system.Drugs39,Suppl1: 21\u201331, 1990.","DOI":"10.2165\/00003495-199000391-00005"},{"key":"R69","doi-asserted-by":"crossref","unstructured":"Kato J, Lanier-Smith KL, and Currie MG.Cyclic GMP down-regulates atrial natriuretic peptide receptors on cultured vascular endothelial cells.J Biol Chem266: 14681\u201314685, 1991.","DOI":"10.1016\/S0021-9258(18)98739-9"},{"key":"R70","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1987.252.6.F1112"},{"key":"R71","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(90)90437-V"},{"key":"R72","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.8.4.312"},{"key":"R73","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1993.75.1.198"},{"key":"R74","doi-asserted-by":"crossref","unstructured":"Klinger JR, Warburton RR, Pietras LA, Swift R, John S, and Hill NS.Exaggerated pulmonary hypertensive response during chronic hypoxia in mice with gene-targeted reductions in natriuretic peptide.Chest114,Suppl1: 79S\u201380S, 1998.","DOI":"10.1378\/chest.114.1_Supplement.79S"},{"key":"R75","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1987.252.5.R1019"},{"key":"R76","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.70.2.241"},{"key":"R77","doi-asserted-by":"crossref","unstructured":"Kozma F, Johnson RA, and Nasjletti A.Role of carbon monoxide in heme-induced vasodilation.Eur J Pharmacol323: R1\u2013R2, 1998.","DOI":"10.1016\/S0014-2999(97)00145-3"},{"key":"R78","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.257.5.H1402"},{"key":"R79","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.271.6.H2368"},{"key":"R80","doi-asserted-by":"publisher","DOI":"10.1038\/312756a0"},{"key":"R81","doi-asserted-by":"publisher","DOI":"10.1007\/BF01819840"},{"key":"R82","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1992.306"},{"key":"R83","unstructured":"Laragh JH, Cannon PJ, and Ames RP.Aldosterone in man: the control of its secretion, its interaction with sodium balance and angiotensin activity. In:Aldosterone, edited by Baulieu EE and Robel P. Oxford: Blackwell Scientific, 1964, p. 327\u2013352."},{"key":"R84","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1989.256.3.H760"},{"key":"R85","doi-asserted-by":"crossref","unstructured":"Leitman DC, Andresen JW, Kuno T, Kamisaki Y, Chang JK, and Murad F.Identification of multiple binding sites for atrial natriuretic factor by affinity cross-linking in cultured endothelial cells.J Biol Chem261: 11650\u201311655, 1986.","DOI":"10.1016\/S0021-9258(18)67292-8"},{"key":"R86","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(86)90040-6"},{"key":"R87","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1993.264.4.E483"},{"key":"R88","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199807303390507"},{"key":"R89","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1988.255.3.H616"},{"key":"R90","doi-asserted-by":"publisher","DOI":"10.1089\/hum.1998.9.10-1429"},{"key":"R91","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1995.tb01919.x"},{"key":"R92","doi-asserted-by":"publisher","DOI":"10.1038\/378065a0"},{"key":"R93","doi-asserted-by":"crossref","unstructured":"Lund-Johansen P.Haemodynamics in essential hypertension.Clin Sci (Colch)59: 343S-354S, 1980.","DOI":"10.1042\/cs059343s"},{"key":"R94","doi-asserted-by":"publisher","DOI":"10.1126\/science.2823385"},{"key":"R95","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1997.272.5.H2139"},{"key":"R96","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.84.12.1453"},{"key":"R97","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.13.7403"},{"key":"R98","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1999.276.6.H1935"},{"key":"R99","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1988.255.1.R182"},{"key":"R100","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199506000-00008"},{"key":"R101","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-0115(98)00149-9"},{"key":"R102","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.1.R255"},{"key":"R103","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(99)00104-2"},{"key":"R104","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1998.275.5.H1826"},{"key":"R105","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1999.277.3.R624"},{"key":"R106","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.13.6252"},{"key":"R107","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.257.5.R1169"},{"key":"R108","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117402"},{"key":"R109","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90724-7"},{"key":"R110","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117763"},{"key":"R111","doi-asserted-by":"crossref","unstructured":"Nicholls MG, Espiner EA, Ikram H, Crozier IG, and Richards AM.Atrial natriuretic peptide in human hypertension.Eur Heart J8,SupplB: 123\u2013128, 1987.","DOI":"10.1093\/eurheartj\/8.suppl_B.123"},{"key":"R112","doi-asserted-by":"publisher","DOI":"10.1536\/ihj.32.167"},{"key":"R113","doi-asserted-by":"publisher","DOI":"10.1172\/JCI113742"},{"key":"R114","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.26.14730"},{"key":"R115","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.5.2547"},{"key":"R116","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.13.5.440"},{"key":"R117","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(90)94168-W"},{"key":"R118","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.8.7.606"},{"key":"R119","doi-asserted-by":"publisher","DOI":"10.1042\/cs0690721"},{"key":"R120","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.26.4.696"},{"key":"R121","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1988.254.4.H811"},{"key":"R122","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)01134-Z"},{"key":"R123","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1992.262.6.E763"},{"key":"R124","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-67-6-1134"},{"key":"R125","doi-asserted-by":"crossref","unstructured":"Richards AM.Is atrial natriuretic factor a physiological regulator of sodium excretion? A review of the evidence.J Cardiovasc Pharmacol16,Suppl7: S39\u2013S42, 1990.","DOI":"10.1097\/00005344-199006167-00013"},{"key":"R126","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.31.1.378"},{"key":"R127","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-199509000-00003"},{"key":"R128","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90741-X"},{"key":"R129","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(86)90475-9"},{"key":"R130","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1990.258.5.R1250"},{"key":"R131","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1995.tb01920.x"},{"key":"R132","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112154"},{"key":"R133","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1986.250.6.F963"},{"key":"R134","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1991.260.6.R1145"},{"key":"R135","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.16.3.301"},{"key":"R136","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1989.257.1.R127"},{"key":"R137","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.15.2.168"},{"key":"R138","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1987.252.6.F992"},{"key":"R139","doi-asserted-by":"crossref","unstructured":"Timmermans PBMWM, Wong PC, Chu AT, Herblin WF, Benfield P, Carini DJ, Lee RJ, Wexler RR, Saye JAM, and Smith RD.Angiotensin II receptors and angiotensin II receptor antagonists.Pharmacol Rev45: 205\u2013251, 1993.","DOI":"10.1016\/S0031-6997(25)00446-6"},{"key":"R140","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1987.252.5.R915"},{"key":"R141","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199007053230106"},{"key":"R142","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1995.269.1.R186"},{"key":"R143","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.60.5.747"},{"key":"R144","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.1996.270.5.H1819"},{"key":"R145","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.89.5.2232"},{"key":"R146","doi-asserted-by":"publisher","DOI":"10.1007\/BF03350033"},{"key":"R147","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-62-5-1027"},{"key":"R148","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.81.23.7661"},{"key":"R149","doi-asserted-by":"publisher","DOI":"10.1016\/0163-7258(90)90058-A"},{"key":"R150","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.23.14860"},{"key":"R151","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.57.3.470"},{"key":"R152","doi-asserted-by":"crossref","unstructured":"Zukowska-Grojec Z, Haass M, Kopin IJ, and Zamir N.Interactions of atrial natriuretic peptide with the sympathetic and endocrine systems in the pithed rat.J Pharmacol Exp Ther239: 480\u2013487, 1986.","DOI":"10.1016\/S0022-3565(25)23576-5"}],"container-title":["Physiological Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physiolgenomics.2000.3.1.45","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T04:48:06Z","timestamp":1751172486000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physiolgenomics.2000.3.1.45"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,6,29]]},"references-count":152,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2000,6,29]]}},"alternative-id":["10.1152\/physiolgenomics.2000.3.1.45"],"URL":"https:\/\/doi.org\/10.1152\/physiolgenomics.2000.3.1.45","relation":{},"ISSN":["1094-8341","1531-2267"],"issn-type":[{"value":"1094-8341","type":"print"},{"value":"1531-2267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,6,29]]}}}