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Mice having no stones and mice having the largest stones were genotyped at \u223c20-cM intervals to find the loci determining cholesterol gallstone formation. The major locus, Lith1, mapped near D2Mit56 and was confirmed by constructing a congenic strain, AK.L- Lith1<jats:sup>s<\/jats:sup>. Another locus, Lith2, mapped near D19Mit58 and was also confirmed by constructing a congenic strain AK.L- Lith2<jats:sup>s<\/jats:sup>. Other suggestive, but not statistically significant, loci mapped to chromosomes 6, 7, 8, 10, and X. The identification of these Lith genes will elucidate the pathophysiology of cholesterol gallstone formation.<\/jats:p>","DOI":"10.1152\/physiolgenomics.2000.4.1.59","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T22:53:16Z","timestamp":1514069596000},"page":"59-65","source":"Crossref","is-referenced-by-count":65,"title":["Quantitative trait loci mapping for cholesterol gallstones in AKR\/J and C57L\/J strains of mice"],"prefix":"10.1152","volume":"4","author":[{"given":"BEVERLY","family":"PAIGEN","sequence":"first","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"NICHOLAS J.","family":"SCHORK","sequence":"additional","affiliation":[{"name":"Case Western Reserve University, Cleveland, Ohio 44109"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"KAREN L.","family":"SVENSON","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"YIN-CHAI","family":"CHEAH","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"JIAN-LONG","family":"MU","sequence":"additional","affiliation":[{"name":"The Jackson Laboratory, Bar Harbor, Maine 04609"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"FRANK","family":"LAMMERT","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Gastroenterology Division, Brigham and Women\u2019s Hospital and Harvard Digestive Diseases Center, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"DAVID Q.-H.","family":"WANG","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Gastroenterology Division, Brigham and Women\u2019s Hospital and Harvard Digestive Diseases Center, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"GUYLAINE","family":"BOUCHARD","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Gastroenterology Division, Brigham and Women\u2019s Hospital and Harvard Digestive Diseases Center, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MARTIN C.","family":"CAREY","sequence":"additional","affiliation":[{"name":"Department of Medicine, Harvard Medical School, Gastroenterology Division, Brigham and Women\u2019s Hospital and Harvard Digestive Diseases Center, Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840070209"},{"key":"R2","unstructured":"Apstein MD and Carey MC.Gallstones. 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