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During embryogenesis, GFP expression was first detected at embryonic day E13 in the adrenal gland and Wolffian duct. Expression was also seen in the developing renal vasculature as early as E14 and remained detectable through birth. Renal GFP expression became restricted to JG cells in adults. Fetal adrenal and gonadal arteries also expressed GFP. In the placenta, GFP was observed in giant cell trophoblasts, consistent with reports of renin expression in chorionic cells of both humans and mice. We conclude that 4 kb of renin 5\u2032 flank is sufficient to direct multiple known renin expression patterns. Furthermore, the renin-GFP construct characterized here will provide a useful vital reporter for renin expression.<\/jats:p>","DOI":"10.1152\/physiolgenomics.2000.4.1.75","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T22:53:16Z","timestamp":1514069596000},"page":"75-81","source":"Crossref","is-referenced-by-count":53,"title":["Expression of a renin\/GFP transgene in mouse embryonic, extra-embryonic, and adult tissues"],"prefix":"10.1152","volume":"4","author":[{"given":"C. A.","family":"JONES","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Roswell Park Cancer Institute, Buffalo 14260"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. I.","family":"HURLEY","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Natural Sciences, D\u2019Youville College, Buffalo, New York 14201"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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