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In addition, body weight and length, adipose tissue mass, plasma lipids and insulin, and aortic fatty lesions were assessed. Bone mass was inversely correlated with extent of atherosclerosis and with a prooxidant lipid profile and directly correlated with body weight, length, and, most strongly, adipose tissue mass. Quantitative trait locus (QTL) analysis, using composite interval mapping (CIM) and multi-trait analysis, identified six loci with multi-trait CIM LOD scores &gt; 5. Three of these coincided with loci linked with adipose tissue and plasma high-density lipoprotein. Application of statistical tests for distinguishing close linkage vs. pleiotropy supported the presence of a potential pleiotropic effect of two of the loci on these traits. This study shows that bone mass in older female mice with atherosclerosis has multiple genetic determinants and provides phenotypic and genetic evidence linking the regulation of bone density with adipose tissue and plasma lipids.<\/jats:p>","DOI":"10.1152\/physiolgenomics.2001.5.4.205","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T22:41:01Z","timestamp":1514068861000},"page":"205-215","source":"Crossref","is-referenced-by-count":60,"title":["Genetic loci determining bone density in mice with diet-induced atherosclerosis"],"prefix":"10.1152","volume":"5","author":[{"given":"THOMAS A.","family":"DRAKE","sequence":"first","affiliation":[{"name":"Departments of Pathology and Laboratory Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ERIC","family":"SCHADT","sequence":"additional","affiliation":[{"name":"Biomathematics, University of California, Los Angeles, California 90095"},{"name":"Department of Bioinformatics, Rosetta Inpharmatics, Kirkland, Washington 98034"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KAMBIZ","family":"HANNANI","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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