{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T22:24:00Z","timestamp":1757543040203},"reference-count":50,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Genomics"],"published-print":{"date-parts":[[2008,12]]},"abstract":"<jats:p> Peroxisome proliferator-activated receptor (PPAR)\u03b1 regulates lipid metabolism at the transcriptional level and modulates the expression of genes involved in inflammation, cell proliferation, and differentiation. Although PPAR\u03b1 has been shown to mitigate cardiac hypertrophy, knowledge about underlying mechanisms and the nature of signaling pathways involved is fragmentary and incomplete. The aim of this study was to identify the processes and signaling pathways regulated by PPAR\u03b1 in hearts challenged by a chronic pressure overload by means of whole genome transcriptomic analysis. PPAR\u03b1\u2212\/\u2212 and wild-type mice were subjected to transverse aortic constriction (TAC) for 28 days, and left ventricular gene expression profile was determined with Affymetrix GeneChip Mouse Genome 430 2.0 arrays containing &gt;45,000 probe sets. In unchallenged hearts, the mere lack of PPAR\u03b1 resulted in 821 differentially expressed genes, many of which are related to lipid metabolism and immune response. TAC resulted in a more pronounced cardiac hypertrophy and more extensive changes in gene expression (1,910 and 312 differentially expressed genes, respectively) in PPAR\u03b1\u2212\/\u2212 mice than in wild-type mice. Many of the hypertrophy-related genes were related to development, signal transduction, actin filament organization, and collagen synthesis. Compared with wild-type hypertrophied hearts, PPAR\u03b1\u2212\/\u2212 hypertrophied hearts revealed enrichment of gene clusters related to extracellular matrix remodeling, immune response, oxidative stress, and inflammatory signaling pathways. The present study therefore demonstrates that, in addition to lipid metabolism, PPAR\u03b1 is an important modulator of immune and inflammatory response in cardiac muscle. <\/jats:p>","DOI":"10.1152\/physiolgenomics.90296.2008","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T00:54:50Z","timestamp":1222217690000},"page":"15-23","source":"Crossref","is-referenced-by-count":30,"title":["Transcriptomic analysis of PPAR\u03b1-dependent alterations during cardiac hypertrophy"],"prefix":"10.1152","volume":"36","author":[{"given":"Pascal J. 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