{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T07:52:57Z","timestamp":1792223577084,"version":"4.4.0"},"reference-count":307,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100012856","name":"U of C | Alberta Children's Hospital Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012866","name":"U of C | Cumming School of Medicine, University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003206","name":"Alberta Children's Hospital Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["RN435448 - 450828"],"award-info":[{"award-number":["RN435448 - 450828"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["CRC Tier 1"],"award-info":[{"award-number":["CRC Tier 1"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN-2021-02417"],"award-info":[{"award-number":["RGPIN-2021-02417"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012856","name":"U of C | Alberta Children's Hospital Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Reviews"],"published-print":{"date-parts":[[2023,10,1]]},"abstract":"<jats:p>The placenta is a unique organ system that functionally combines both maternal and fetal cell types with distinct lineage origins. Normal placentation is critical for developmental progression and reproductive success. Although the placenta is best known for its nutrient supply function to the fetus, genetic experiments in mice highlight that the placenta is also pivotal for directing the proper formation of specific fetal organs. These roles underscore the importance of the placenta for pregnancy outcome and lifelong health span, which makes it essential to better understand the molecular processes governing placental development and function and to find adequate models to study it. In this review, we provide an overview of placental development and highlight the instructional role of the epigenome in dictating cell fate decisions specifically in the placental trophoblast cell lineage. We then focus on recent advances in exploring stem cell and organoid models reflecting the feto-maternal interface in mice and humans that provide much-improved tools to study events in early development. We discuss stem cells derived from the placenta as well as those artificially induced to resemble the placenta, and how they can be combined with embryonic stem cells and with endometrial cell types of the uterus to reconstitute the early implantation site. We then allude to the exciting prospects of how these models can be harnessed in biomedicine to enhance our understanding of the pathological underpinnings of pregnancy complications in a patient-specific manner, and ultimately to facilitate therapeutic approaches of tissue- and organ-based regenerative medicine.<\/jats:p>","DOI":"10.1152\/physrev.00001.2023","type":"journal-article","created":{"date-parts":[[2023,5,12]],"date-time":"2023-05-12T11:26:11Z","timestamp":1683890771000},"page":"2523-2560","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["The placenta: epigenetic insights into trophoblast developmental models of a generation-bridging organ with long-lasting impact on lifelong health"],"prefix":"10.1152","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-6958","authenticated-orcid":false,"given":"Myriam","family":"Hemberger","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"},{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9441-5044","authenticated-orcid":false,"given":"Wendy","family":"Dean","sequence":"additional","affiliation":[{"name":"Alberta Children\u2019s Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada"},{"name":"Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7985020"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1038\/35080570"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0066"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2021.0261"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dml016"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-4199-5"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.102.014977"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2005.12.006"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-019-02058-w"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12563"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1038358"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.04.010"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00001.2005"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/s1043-2760(01)00375-7"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00570"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.11.577"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1159\/000359969"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46151-6"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)80209-9"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00014-6"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22040-2"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1038\/srep20999"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abj5445"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2200582119"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2443.2003.00680.x"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1242\/dev.022707"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0609041104"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00629"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00735"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nature26002"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36740-5"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.16.04023"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.06.013"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-16461-8"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.08.003"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021793"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/s00246-018-1876-x"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.21037\/tp-20-347"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1038\/s41390-021-01521-7"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1038\/nature09972"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00896-4"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1126\/science.aam6607"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04816-9"},{"key":"B45","first-page":"K19","volume":"30","author":"D\u00f6rner G","year":"1973","journal-title":"Acta Biol Med Ger"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.301.6746.259"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2007.01809.x"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31829cb9ca"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.311.6998.171"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00029.2015"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00002.2020"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.06357"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11061576"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6080076"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1038\/s41576-019-0169-4"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.06.010"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1242\/dev.017178"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.16.3913"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0051-0"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04363-6"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2006.11.002"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0887"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1002\/jez.1402280221"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03104-6"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1016\/s0143-4004(80)80012-9"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02597"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2017.00041"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.07.050"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(09)00436-9"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/nri1897"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1093\/pcmedi\/pbac002"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(92)90055-x"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11414"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4407"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.60266"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/s0074-7696(08)62220-2"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2132-6"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1093\/molehr\/gal116"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-9-352"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0066-y"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0698-6"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aau4788"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2002449117"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1242\/dev.199840"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05869-0"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgaa503"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04285-3"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016517118"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.3390\/cells12010087"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1530\/REP-20-0231"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.16970"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.21203\/rs.3.rs-1898137\/v1"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1038\/150563a0"},{"key":"B94","unstructured":"Waddington CH. The Strategy of the Genes; a Discussion of Some Aspects of Theoretical Biology. London: Allen & Unwin, 1957."},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063127"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a025064"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)57261-6"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2037511"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063443"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddi114"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.11.025"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02500"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.001"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/nature08829"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2016.07.019"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-120116-024544"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-9822(03)00419-6"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/307284a0"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-017-0003-x"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1038\/nature23891"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1249"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(86)90325-8"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1215145110"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msx112"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04568-9"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-023-01114-y"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1242\/dev.048363"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2010.03.018"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1101\/gr.114843.110"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053880"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201797038"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.15252\/embj.201798498"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1038\/ng1950"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1101\/gr.125872.111"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1098\/rsob.180081"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2021.04.001"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2015.05.006"},{"key":"B128","doi-asserted-by":"crossref","unstructured":"Dean W, Hanna CW. Epigenetics of early mammalian development: a pathway to regenerative medicine. In: Epigenetics and Regeneration, edited by Palacios D. London: Academic Press, 2019, p. 133\u2013163.","DOI":"10.1016\/B978-0-12-814879-2.00006-6"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1126\/science.1065848"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1038\/nature02633"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1002\/9780470515501.ch11"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1023\/A:1003990818251"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/2413"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90611-f"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.02.006"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.022"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1038\/nature13415"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/nature06397"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1038\/nature07249"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2391"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms2562"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1101\/gad.284992.116"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.4161\/cc.7.22.6979"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1649908"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2014.05.008"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.11.019"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1038\/nature08752"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.06.009"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1038\/nature12750"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-11454-0_9"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/8.7.1499"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1038\/362709a0"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1093\/molbev\/msi026"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.26.021607.090350"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00642"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1038\/nature12299"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.01.008"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1186\/1756-8935-6-39"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/nature12362"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2807"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1126\/science.1169786"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1126\/science.1170116"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2011.01.008"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20844"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2012.0292"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200403109"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1007\/s00412-007-0106-8"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.241522698"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061470"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.1667"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1038\/nature09342"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1111\/gtc.12227"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1418"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3584"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.614234"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1101\/gad.348782.121"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1038\/292154a0"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1038\/309255a0"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/s0070-2153(08)60675-4"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(84)90133-7"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5391.1145"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0592-534"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002019"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5396.2072"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01715"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2014.09.008"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2017.11.004"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2018.07.004"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0753-3"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1604747113"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3516"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1242\/dev.148478"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1007\/BF02796347"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2013.12.013"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1101\/gad.268821.115"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.137125"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1002\/stem.3052"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.63254"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2022.06.002"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2013.09.002"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2008.07.027"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12720-6"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2105130118"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.673065"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad215"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.04.028"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1530\/rep.1.00217"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq151"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-017-0007-6"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.08.040"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1089\/scd.2014.0395"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1038\/ng.173"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms6538"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1038\/nature06968"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2510"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx692"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.08.005"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.08.006"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2019.12.017"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27586-w"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1038\/nature24052"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2017.02.005"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.04.034"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-020-00609-2"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1038\/nbt761"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del017"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq128"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1303094110"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1002\/cpsc.96"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108419"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.01.006"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.03.013"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2021.02.025"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.06.003"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.52504"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-022-00932-w"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abf4416"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.09.008"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2022.04.013"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2734-6"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-022-00742-2"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1242\/dev.133462"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.00726"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaj2239"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.9.1315"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01819"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1786"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1242\/dev.129.11.2733"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.9.3149-3156.2002"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.02.015"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2020.04.009"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06666-4"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1038\/nature10066"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1038\/nature09934"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3868"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1038\/74199"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1101\/sqb.2004.69.381"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.2.876-883.2005"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1101\/gad.2008511"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.227637"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1038\/nature11244"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2006337"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.04.002"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2553"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1038\/35001608"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0406509102"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2013.08.005"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2021.07.008"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1126\/science.aal1810"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2019.11.014"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1038\/s41596-018-0005-x"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.09.029"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2019.07.011"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0147-7"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05246-3"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.07.028"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-04267-8"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2383-9"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258096"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.20674"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-018-07663-9"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1038\/359076a0"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1335.020"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.3115"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.87.6.8563"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.109.083154"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618433114"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04848-8"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1210\/er.2018-00281"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202101170RR"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2007.01.007"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00308-x"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1242\/dev.185629"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2020.06.006"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1016\/j.midw.2010.07.006"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2006.10.030"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1016\/j.ppedcard.2021.101385"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000140682.63746.be"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186287"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-010-1459-4"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1111\/j.1447-0756.2008.00855.x"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1038\/nature14361"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1186\/s12958-022-00973-8"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1002\/cpz1.88"},{"key":"B307","first-page":"297","volume":"94","author":"Hamilton WJ","year":"1960","journal-title":"J Anat"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1016\/s0002-9378(99)70518-1"}],"container-title":["Physiological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physrev.00001.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T14:20:04Z","timestamp":1690294804000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physrev.00001.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,1]]},"references-count":307,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,10,1]]}},"alternative-id":["10.1152\/physrev.00001.2023"],"URL":"https:\/\/doi.org\/10.1152\/physrev.00001.2023","relation":{},"ISSN":["0031-9333","1522-1210"],"issn-type":[{"value":"0031-9333","type":"print"},{"value":"1522-1210","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,1]]},"assertion":[{"value":"2023-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-24","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}