{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:22:04Z","timestamp":1792153324200,"version":"4.4.0"},"reference-count":656,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BOUCHE19R0"],"award-info":[{"award-number":["BOUCHE19R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BOUCHE19XX0"],"award-info":[{"award-number":["BOUCHE19XX0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BOUCHE19XX0"],"award-info":[{"award-number":["BOUCHE19XX0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BUTTON19G0"],"award-info":[{"award-number":["BUTTON19G0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["HILL19G0"],"award-info":[{"award-number":["HILL19G0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["HILL20Y2-OUT"],"award-info":[{"award-number":["HILL20Y2-OUT"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["BOUCHE19XX0"],"award-info":[{"award-number":["BOUCHE19XX0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UH3HL123645"],"award-info":[{"award-number":["UH3HL123645"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL136961"],"award-info":[{"award-number":["R01HL136961"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01HL108808"],"award-info":[{"award-number":["P01HL108808"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01HL108808"],"award-info":[{"award-number":["P01HL108808"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL125280"],"award-info":[{"award-number":["R01HL125280"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"HHS | NIH | National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["P01HL108808"],"award-info":[{"award-number":["P01HL108808"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK065988"],"award-info":[{"award-number":["P30DK065988"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK065988"],"award-info":[{"award-number":["P30DK065988"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["P30DK065988"],"award-info":[{"award-number":["P30DK065988"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["EFMA-1830957"],"award-info":[{"award-number":["EFMA-1830957"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Reviews"],"published-print":{"date-parts":[[2022,10,1]]},"abstract":"<jats:p>The mucus clearance system is the dominant mechanical host defense system of the human lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid pumping and cough-dependent mechanisms, and mucus transport rates are heavily dependent on mucus concentration. Importantly, mucus transport rates are accurately predicted by the gel-on-brush model of the mucociliary apparatus from the relative osmotic moduli of the mucus and periciliary-glycocalyceal (PCL-G) layers. The fluid available to hydrate mucus is generated by transepithelial fluid transport. Feedback interactions between mucus concentrations and cilia beating, via purinergic signaling, coordinate Na<jats:sup>+<\/jats:sup>absorptive vs Cl<jats:sup>\u2212<\/jats:sup>secretory rates to maintain mucus hydration in health. In disease, mucus becomes hyperconcentrated (dehydrated). Multiple mechanisms derange the ion transport pathways that normally hydrate mucus in muco-obstructive lung diseases, e.g., cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), non-CF bronchiectasis (NCFB), and primary ciliary dyskinesia (PCD). A key step in muco-obstructive disease pathogenesis is the osmotic compression of the mucus layer onto the airway surface with the formation of adherent mucus plaques and plugs, particularly in distal airways. Mucus plaques create locally hypoxic conditions and produce airflow obstruction, inflammation, infection, and, ultimately, airway wall damage. Therapies to clear adherent mucus with hydrating and mucolytic agents are rational, and strategies to develop these agents are reviewed.<\/jats:p>","DOI":"10.1152\/physrev.00004.2021","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T11:03:42Z","timestamp":1641812622000},"page":"1757-1836","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":381,"title":["Physiology and pathophysiology of human airway mucus"],"prefix":"10.1152","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9270-777X","authenticated-orcid":true,"given":"David B.","family":"Hill","sequence":"first","affiliation":[{"name":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"},{"name":"Joint Department of Biomedical Engineering, The University of North Carolina and North Carolina State University, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8623-0576","authenticated-orcid":true,"given":"Brian","family":"Button","sequence":"additional","affiliation":[{"name":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5455-0951","authenticated-orcid":true,"given":"Michael","family":"Rubinstein","sequence":"additional","affiliation":[{"name":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"},{"name":"Department of Mechanical Engineering and Materials Science, Biomedical Engineering, Physics, and Chemistry, Duke University, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5745-3989","authenticated-orcid":true,"given":"Richard C.","family":"Boucher","sequence":"additional","affiliation":[{"name":"Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI0215217"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0910061"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1973.00320070111013"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02374-20"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1934.03600040074006"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1965.10664231"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1007\/BF03027208"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1223012"},{"key":"B9","first-page":"1134","volume":"52","author":"Rogers DF","year":"2007","journal-title":"Respir Care"},{"key":"B10","doi-asserted-by":"crossref","unstructured":"Jones PW. St George\u2019s Respiratory Questionnaire: MCID.COPD2: 75\u201379, 2005. doi:10.1081\/copd-200050513.","DOI":"10.1081\/COPD-200050513"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1952.03680140045014"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201706-1139OC"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00219053"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201412-2230OC"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2014.09.018"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03550170056032"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2004.07.009"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00025.2015"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.15326\/jcopdf.7.4.2020.0135"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2014"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00141514"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1969.10665482"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav3488"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00023.2019"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1813799"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2021.06.093"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-87553-3"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2013.02.003"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087681"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.70.113006.100702"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2016.10.055"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00010.2005"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/jcm6120112"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.149310"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201804-0734OC"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008649.pub3"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122475"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(72)90011-1"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2003-0262OC"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2008.08.003"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.70.113006.100638"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00347.2013"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002257"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0460OC"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2004-0220RC"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200811-1744OC"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.114"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2011.03852.x"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00079-5"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201806-371AW"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124815"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0199319"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0011PS"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.63.1.555"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1159\/000078172"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0530OC"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2012.08.020"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1984.130.2.275"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1977.115.5.819"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/path.1711060204"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1159\/000193659"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00404.2014"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00457-2018"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.08.113"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201804-238AW"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201004-0643OC"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-64695-w"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032158"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201507-1281OC"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.3109\/15513818409041187"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.4.916"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/140.2.477"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(03)00241-9"},{"key":"B74","first-page":"771","volume":"49","author":"Reid L","year":"1956","journal-title":"Proc R Soc Med"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1963.88.2.199"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73469"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1701632"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00398.2016"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01297-2018"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606428103"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1172\/JCI119802"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.117.5.423"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1172\/JCI11154"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.119.1.3"},{"key":"B85","first-page":"54","volume":"12","author":"Claas GJ","year":"2007","journal-title":"Eur J Med Res"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.117.6.573"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118463"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1484-5"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.24.3.4367"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2016-0161OC"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711888"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.2.8049852"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.1.8025763"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1981.50.3.613"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4546"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117397"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1994.76.6.2275"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-100617-062818"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00238.2019"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-018-0057-2"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-53547-x"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.09.021"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.23.14442"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.16.9845"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.09.023"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms7281"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1038\/nature12807"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20499-0"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.2147\/JAA.S312361"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.molbev.a026400"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201802-143AW"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010771"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2012.81"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2104490118"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1172\/JCI84910"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1811787115"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3010525"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16223-7"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201312-2220LE"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1021\/ma0013049"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-019-0581-8"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9060675"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2014.02.038"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200909-1434OC"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0670OC"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01984-19"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.65355"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.63"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2018.04.003"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.5.1670"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.10.003"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2019.07.042"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202008-3198OC"},{"key":"B134","unstructured":"Davidson JD.Multiscale Modeling and Simulation of Crosslinked Polymers(Dissertation). Ann Arbor, MI: University of Michigan, 2014."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms4781"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200501-009AC"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0080SF"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.042689399"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.261.5.C727"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1991.260.2.L90"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00319.2015"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0347OC"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.162933"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2016.04.008"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1016\/j.cocis.2018.01.001"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2016.08.076"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1968.98.3.449"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200506-987OC"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2015-0238RC"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00013.2017"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00545.2018"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M405367200"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M505832200"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e04-11-1010"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0393-7"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2020.110869"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2020-0708"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1038\/ng0593-27"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092090"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1042\/BST20191010"},{"key":"B161","volume":"54","author":"Okuda K","year":"2019","journal-title":"Pediatr Pulmonol"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16239-z"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201911-2199OC"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2012.12.040"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1172\/JCI129833"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009563"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200810097"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00039.2011"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163518"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.140076"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201507-405KV"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00102.2011"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00532-5"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2634339100"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00112.2020"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(90)82385-7"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5193(05)80362-5"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.6.C1751"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.6.C1764"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2009.04.026"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.11.045"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0348OC"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00437.2007"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00303.2011"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903609106"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.5.C1054"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.2.C226"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.5.C1045"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.5.C1033"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-2314fje"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100737200"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.2000.279.1.C81"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.3.C976"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00075.2002"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.201711860"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2012.240838"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.09.024"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2015.7.4.367"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.590262"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00311.2001"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.3.C644"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-160648"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2002.129412"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710196114"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114316"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600747"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2009.03.015"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1038\/nm1028"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.4869"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108223250802"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125669"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1991.tb09842.x"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-1217-1_3"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617383114"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M801516200"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003755"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114387"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201404-0703OC"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603019200"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0367OC"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.260562"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.010699"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-015-1757-6"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07221-9"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800141105"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00371.2012"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1021\/bi7009647"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000078882.11919.AF"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-4804(03)00195-1"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-005-8050-5"},{"key":"B231","first-page":"648","volume":"40","author":"Brown HA","year":"1991","journal-title":"Mol Pharmacol"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M301734200"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81724-9"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(01)00286-6"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2006.126086"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.68.072304.112754"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13047"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtbi.2017.11.010"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-013-9400-5"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.3390\/life11050430"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/144.3_pt_2.S33"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009597"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.3233\/bir-1987-24615"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.4161\/gmic.1.1.10470"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1407597111"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.186643"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0240OC"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116756"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00219.2019"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1186\/rr25"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2410"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81895-4"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59653"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1038\/ng1192-240"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705179114"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.43.2.152"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1161\/01.res.43.6.925"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1007\/112_2019_16"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.120994"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112708"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1126\/science.6308769"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0177OC"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02652-2017"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.52.030190.001033"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.47.1.331"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.37.1.1"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.33.1.15"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.3.2.207"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5193(86)80098-4"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-008-0416-9"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33053-2"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028241"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0417OC"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803970105"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.69.040705.141253"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.3390\/cells5040040"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1071\/BI9490271"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1126\/science.1128618"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2009.09.048"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.3.001978"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnnfm.2012.12.016"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1016\/j.biolcel.2004.08.001"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(03)75136-4"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1002\/cm.10049"},{"key":"B285","first-page":"501","volume":"42","author":"K\u00f6nig K","year":"1996","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(04)74110-7"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.106.094698"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.37.3.461"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)76999-7"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(00)76308-9"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00105.2012"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.12.022"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1172\/JCI2687"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod23.4.788"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.75.9.4413"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.2147\/copd.s6133"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.3233\/bir-1981-183-628"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.3233\/bir-1983-20214"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.4187\/respcare.04087"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M309026200"},{"key":"B301","volume-title":"Structural and Rheological Properties of Airway Mucus & Counterion Condensation around Charged Nanoparticles","author":"Tang Q","year":"2021"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.20.4.3264"},{"key":"B303","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198520597.001.0001","volume-title":"Polymer Physics","author":"Rubinstein M","year":"2003"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1002\/bip.22372"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.3233\/bir-1989-26406"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevE.80.012501"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.1.8111599"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2020.03.004"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.9b00482"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.03.005"},{"key":"B311","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1183\/09031936.93.04030311","volume":"4","author":"Zahm JM","year":"1991","journal-title":"Eur Respir J"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1985.58.6.1776"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.3233\/bir-1987-24611"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.3233\/bir-1994-31102"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1093\/ptj\/48.5.439"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1985.131.S5.S39"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1542\/peds.60.2.146"},{"key":"B318","doi-asserted-by":"publisher","DOI":"10.1016\/S0004-9514(06)70029-0"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00274.2018"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1122\/8.0000015"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0019919"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2016.182"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.012"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2020-215185"},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-73459-5"},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.88198"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07768-9"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1021\/bm401356q"},{"key":"B329","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911748107"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0608611104"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.125954"},{"key":"B332","first-page":"279","volume":"48","author":"Donaldson SH","year":"2013","journal-title":"Pediatr Pulmonol"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1016\/S1359-0294(99)90010-9"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.7b00809"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1103\/PhysRevLett.85.888"},{"key":"B336","doi-asserted-by":"publisher","DOI":"10.1122\/1.4943988"},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.1039\/c4sm00676c"},{"key":"B338","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(50)90048-6"},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4827(50)90002-4"},{"key":"B340","doi-asserted-by":"publisher","DOI":"10.1122\/1.4811477"},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1977.42.6.797"},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1016\/0304-4165(76)90380-9"},{"key":"B343","first-page":"102","volume":"12","author":"Litt M","year":"1975","journal-title":"Biorheology"},{"key":"B344","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.126.3.417"},{"key":"B345","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.94.07091616"},{"key":"B346","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.4_Pt_1.1040"},{"key":"B347","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1502281112"},{"key":"B348","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.06.001"},{"key":"B349","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00001.2009"},{"key":"B350","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav3505"},{"key":"B351","doi-asserted-by":"publisher","DOI":"10.1089\/jam.2006.19.110"},{"key":"B352","doi-asserted-by":"publisher","DOI":"10.1139\/y95-025"},{"key":"B353","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0297OC"},{"key":"B354","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2012.01929.x"},{"key":"B355","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2005-0440OC"},{"key":"B356","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00269-2020"},{"key":"B357","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196806202782501"},{"key":"B358","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201906-1219OC"},{"key":"B359","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag1370"},{"key":"B360","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2007.02.004"},{"key":"B361","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30504-X"},{"key":"B362","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2021.01.041"},{"key":"B363","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08030381"},{"key":"B364","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/408935"},{"key":"B365","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2002.01014.x"},{"key":"B366","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13038"},{"key":"B367","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm-conference.2010.181.1_MeetingAbstracts.A5510"},{"key":"B368","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2006.11.009"},{"key":"B369","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60595-4"},{"key":"B370","doi-asserted-by":"crossref","DOI":"10.1164\/rccm.200309-1293OC","volume":"169","author":"Bennett W","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"B371","doi-asserted-by":"publisher","DOI":"10.1378\/chest.102.2.412"},{"key":"B372","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-5231(21)01014-5"},{"key":"B373","doi-asserted-by":"publisher","DOI":"10.1378\/chest.129.1.118"},{"key":"B374","first-page":"159","volume-title":"Cough: Causes, Mechanisms and Therapy","author":"Mazzone SB","year":"2008"},{"key":"B375","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00612.2016"},{"key":"B376","volume-title":"Clinical Methods: The History, Physical, and Laboratory Examinations","author":"Farzan S","year":"1990"},{"key":"B377","doi-asserted-by":"publisher","DOI":"10.1136\/thx.49.6.557"},{"key":"B378","volume-title":"Mechanics of Fluids","author":"Massey BS","year":"2012"},{"key":"B379","doi-asserted-by":"publisher","DOI":"10.1115\/1.3240948"},{"key":"B380","doi-asserted-by":"publisher","DOI":"10.1039\/c3sm52883a"},{"key":"B381","doi-asserted-by":"publisher","DOI":"10.21769\/BioProtoc.3287"},{"key":"B382","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.118.2.223"},{"key":"B383","doi-asserted-by":"publisher","DOI":"10.1021\/pr300058z"},{"key":"B384","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2015.12.1121"},{"key":"B385","doi-asserted-by":"publisher","DOI":"10.1172\/JCI95693"},{"key":"B386","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.3.908"},{"key":"B387","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1986.60.3.901"},{"key":"B388","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9290(78)90011-8"},{"key":"B389","doi-asserted-by":"publisher","DOI":"10.1378\/chest.98.3.608"},{"key":"B390","first-page":"1210","volume":"52","author":"Fink JB","year":"2007","journal-title":"Respir Care"},{"key":"B391","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1984.130.5.701"},{"key":"B392","doi-asserted-by":"publisher","DOI":"10.1378\/chest.95.3.658"},{"key":"B393","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200912-1843CC"},{"key":"B394","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.03.012"},{"key":"B395","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra043184"},{"key":"B396","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21154"},{"key":"B397","doi-asserted-by":"publisher","DOI":"10.1136\/thx.7.3.213"},{"key":"B398","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.10010610"},{"key":"B399","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S319972"},{"key":"B400","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.58.071905.105316"},{"key":"B401","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043891"},{"key":"B402","doi-asserted-by":"publisher","DOI":"10.1172\/JCI72948"},{"key":"B403","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.23.1.7"},{"key":"B404","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21587"},{"key":"B405","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90574-0"},{"key":"B406","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201310-360OC"},{"key":"B407","doi-asserted-by":"publisher","DOI":"10.1148\/radiographics.20.3.g00ma01673"},{"key":"B408","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.05.042"},{"key":"B409","doi-asserted-by":"publisher","DOI":"10.1136\/thx.29.3.304"},{"key":"B410","doi-asserted-by":"publisher","DOI":"10.1542\/peds.44.3.315"},{"key":"B411","doi-asserted-by":"publisher","DOI":"10.1017\/jfm.2020.1162"},{"key":"B412","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.169.12.6985"},{"key":"B413","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(11)60021-0"},{"key":"B414","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1233OC"},{"key":"B415","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.2000530"},{"key":"B416","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800725"},{"key":"B417","doi-asserted-by":"publisher","DOI":"10.1002\/path.4462"},{"key":"B418","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201906-427CME"},{"key":"B419","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00026910"},{"key":"B420","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2008-0223OC"},{"key":"B421","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2007-0452OC"},{"key":"B422","doi-asserted-by":"publisher","DOI":"10.1096\/fj.08-110221"},{"key":"B423","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(21)01790-2"},{"key":"B424","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13419"},{"key":"B425","doi-asserted-by":"publisher","DOI":"10.3390\/biom11081065"},{"key":"B426","first-page":"6","volume":"147","author":"Cole PJ","year":"1986","journal-title":"Eur J Respir Dis Suppl"},{"key":"B427","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201409-1610OC"},{"key":"B428","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201806-368AW"},{"key":"B429","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.07.007"},{"key":"B430","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2016.08.064"},{"key":"B431","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-26777-9"},{"key":"B432","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00455.2001"},{"key":"B433","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)62040-8"},{"key":"B434","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00140.2004"},{"key":"B435","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01762-4"},{"key":"B436","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13870"},{"key":"B437","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32542-3"},{"key":"B438","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.01876-14"},{"key":"B439","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.1090"},{"key":"B440","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2007.12.001"},{"key":"B441","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.720742"},{"key":"B442","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807984115"},{"key":"B443","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02622-19"},{"key":"B444","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1512057112"},{"key":"B445","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006798"},{"key":"B446","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200708-1151OC"},{"key":"B447","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.00295-13"},{"key":"B448","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2016.06.007"},{"key":"B449","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000003211"},{"key":"B450","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005846"},{"key":"B451","doi-asserted-by":"publisher","DOI":"10.1128\/mSphere.00343-20"},{"key":"B452","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00060-20"},{"key":"B453","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201507-472OC"},{"key":"B454","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccm.2012.02.004"},{"key":"B455","doi-asserted-by":"publisher","DOI":"10.1136\/thx.5.3.233"},{"key":"B456","doi-asserted-by":"publisher","DOI":"10.1136\/thx.6.3.268"},{"key":"B457","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2014.01.012"},{"key":"B458","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1027OC"},{"key":"B459","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-100819-121537"},{"key":"B460","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.10.006"},{"key":"B461","doi-asserted-by":"publisher","DOI":"10.1126\/science.aba0629"},{"key":"B462","doi-asserted-by":"publisher","DOI":"10.1002\/lary.25335"},{"key":"B463","doi-asserted-by":"publisher","DOI":"10.1002\/lary.21921"},{"key":"B464","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.70"},{"key":"B465","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0235-1"},{"key":"B466","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.39"},{"key":"B467","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.653969"},{"key":"B468","volume-title":"A Treatise on the Diagnosis and Treatment of Diseases of the Chest","author":"Stokes W","year":"1837"},{"key":"B469","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2006.04.023"},{"key":"B470","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00535-2015"},{"key":"B471","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106623"},{"key":"B472","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201902-0310UP"},{"key":"B473","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1300109"},{"key":"B474","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.03.00057003"},{"key":"B475","doi-asserted-by":"publisher","DOI":"10.1542\/peds.16.2.207"},{"key":"B476","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90155-6"},{"key":"B477","doi-asserted-by":"publisher","DOI":"10.1126\/science.257.5073.1125"},{"key":"B478","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-020-02440-y"},{"key":"B479","doi-asserted-by":"publisher","DOI":"10.1098\/rsif.2019.0187"},{"key":"B480","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052739"},{"key":"B481","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1106695108"},{"key":"B482","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109795"},{"key":"B483","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-002-0955-1"},{"key":"B484","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-409x(02)00144-8"},{"key":"B485","doi-asserted-by":"publisher","DOI":"10.1007\/s00232-008-9126-4"},{"key":"B486","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)61162-9"},{"key":"B487","doi-asserted-by":"publisher","DOI":"10.1172\/JCI83922"},{"key":"B488","first-page":"90","volume":"103","author":"Reid L","year":"1979","journal-title":"Scand J Respir Dis Suppl"},{"key":"B489","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.47.545.171"},{"key":"B490","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2004.08.001"},{"key":"B491","doi-asserted-by":"publisher","DOI":"10.1080\/15412550500218148"},{"key":"B492","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00088-2019"},{"key":"B493","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1311999110"},{"key":"B494","doi-asserted-by":"publisher","DOI":"10.1021\/bm0609691"},{"key":"B495","doi-asserted-by":"publisher","DOI":"10.1385\/CRIAI:23:1:005"},{"key":"B496","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2013-203204"},{"key":"B497","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00605.2005"},{"key":"B498","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.03.003"},{"key":"B499","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201510-2112OC"},{"key":"B500","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200207-765OC"},{"key":"B501","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410618200"},{"key":"B502","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3000928"},{"key":"B503","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2017.11.008"},{"key":"B504","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201708-1616OC"},{"key":"B505","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aau7531"},{"key":"B506","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01763-21"},{"key":"B507","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.24702"},{"key":"B508","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0061OC"},{"key":"B509","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201504-0657OC"},{"key":"B510","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201507-460AW"},{"key":"B511","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2012.04.006"},{"key":"B512","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix203"},{"key":"B513","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2007.12.002"},{"key":"B514","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10050282"},{"key":"B515","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.68.7.4331-4334.2000"},{"key":"B516","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201504-198OC"},{"key":"B517","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.23036"},{"key":"B518","doi-asserted-by":"publisher","DOI":"10.1172\/JCI43466"},{"key":"B519","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M512766200"},{"key":"B520","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208826200"},{"key":"B521","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407077200"},{"key":"B522","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.124863"},{"key":"B523","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1703228114"},{"key":"B524","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2020.07.002"},{"key":"B525","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255825"},{"key":"B526","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1997.272.2.L372"},{"key":"B527","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1998.274.5.L762"},{"key":"B528","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00143.2012"},{"key":"B529","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1999.277.4.L694"},{"key":"B530","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00388.2010"},{"key":"B532","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200703-042BR"},{"key":"B533","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1836ED"},{"key":"B534","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.05.014"},{"key":"B535","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.133400"},{"key":"B536","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00395.2015"},{"key":"B537","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202002-0369OC"},{"key":"B538","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111972"},{"key":"B539","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1900475"},{"key":"B540","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.10.43"},{"key":"B541","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200504-045SR"},{"key":"B542","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.23879"},{"key":"B543","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2019.06.015"},{"key":"B544","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202006-2248OC"},{"key":"B545","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202011-4178ED"},{"key":"B546","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-192377"},{"key":"B547","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00070.2005"},{"key":"B548","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00019.2004"},{"key":"B549","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00049.2019"},{"key":"B550","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200709-1413OC"},{"key":"B551","doi-asserted-by":"publisher","DOI":"10.1016\/j.prrv.2015.09.001"},{"key":"B552","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2018.05.007"},{"key":"B553","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30374-1"},{"key":"B554","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201805-0819ST"},{"key":"B555","doi-asserted-by":"publisher","DOI":"10.1186\/s12920-021-01084-w"},{"key":"B556","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.22984"},{"key":"B557","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.02164-13"},{"key":"B558","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201301-0059CI"},{"key":"B559","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31767-7"},{"key":"B560","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.105954"},{"key":"B561","first-page":"737","volume":"79","author":"Kurashima A","year":"2004","journal-title":"Kekkaku"},{"key":"B562","doi-asserted-by":"publisher","DOI":"10.1259\/bjro.20210026"},{"key":"B563","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201502-0387OC"},{"key":"B564","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00277-0"},{"key":"B565","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00937"},{"key":"B566","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201711-2202OC"},{"key":"B567","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12182"},{"key":"B568","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-305147"},{"key":"B569","doi-asserted-by":"publisher","DOI":"10.1378\/chest.136.4_MeetingAbstracts.8S-f"},{"key":"B570","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12293-8"},{"key":"B571","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.3.198"},{"key":"B572","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2019.02.003"},{"key":"B573","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2016.11.021"},{"key":"B574","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201811-2083OC"},{"key":"B575","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2290"},{"key":"B576","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201210-1937OC"},{"key":"B577","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2020.106285"},{"key":"B578","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.6.1605"},{"key":"B579","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198909283211304"},{"key":"B580","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0055-2019"},{"key":"B581","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01289-7"},{"key":"B582","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00164-2019"},{"key":"B583","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00629-2017"},{"key":"B584","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201303-0411CI"},{"key":"B585","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2013-304831"},{"key":"B586","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2018.1503540"},{"key":"B587","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2009.07.001"},{"key":"B588","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2014.04.006"},{"key":"B589","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2019.08.027"},{"key":"B590","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00808-15"},{"key":"B591","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.10.001"},{"key":"B592","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00022-14"},{"key":"B593","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1105185"},{"key":"B594","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904709106"},{"key":"B595","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1807120"},{"key":"B596","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1908639"},{"key":"B597","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100665"},{"key":"B598","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2020.07.023"},{"key":"B599","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.01662"},{"key":"B600","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709847"},{"key":"B601","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(20)30510-5"},{"key":"B602","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32597-8"},{"key":"B603","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(19)30337-6"},{"key":"B604","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201910-1943SO"},{"key":"B605","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2017.09.013"},{"key":"B606","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201509-601KV"},{"key":"B607","doi-asserted-by":"publisher","DOI":"10.2147\/COPD.S257474"},{"key":"B608","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2021.02.011"},{"key":"B609","doi-asserted-by":"publisher","DOI":"10.1136\/jim-2020-001479"},{"key":"B610","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25740"},{"key":"B611","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2018.09.007"},{"key":"B612","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00716-2019"},{"key":"B613","doi-asserted-by":"publisher","DOI":"10.3390\/genes12030453"},{"key":"B614","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-01091"},{"key":"B615","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00946-2020"},{"key":"B616","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00746-2021"},{"key":"B617","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00447-2020"},{"key":"B618","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2015.06.002"},{"key":"B619","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2020.07.009"},{"key":"B620","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043900"},{"key":"B621","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2018.01.001"},{"key":"B622","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008816.pub4"},{"key":"B623","doi-asserted-by":"publisher","DOI":"10.1183\/23120541.00062-2021"},{"key":"B624","doi-asserted-by":"publisher","DOI":"10.1136\/thx.53.11.953"},{"key":"B625","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.55.2.114"},{"key":"B626","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-014-0138-6"},{"key":"B627","doi-asserted-by":"publisher","DOI":"10.1080\/15412555.2019.1566892"},{"key":"B628","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189834"},{"key":"B629","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01770-2016"},{"key":"B630","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.25206"},{"key":"B631","doi-asserted-by":"publisher","DOI":"10.1177\/1753466619866102"},{"key":"B632","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.11.1.15"},{"key":"B633","doi-asserted-by":"publisher","DOI":"10.1080\/07853890600585795"},{"key":"B634","doi-asserted-by":"publisher","DOI":"10.1159\/000442794"},{"key":"B635","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007168.pub2"},{"key":"B636","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2020.1739525"},{"key":"B637","doi-asserted-by":"publisher","DOI":"10.1055\/s-0041-1730922"},{"key":"B638","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201802-0245OC"},{"key":"B639","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9949453"},{"key":"B640","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12744"},{"key":"B641","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2013.11.002"},{"key":"B642","doi-asserted-by":"publisher","DOI":"10.1016\/j.vibspec.2019.102932"},{"key":"B643","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00794"},{"key":"B644","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-021-01599-z"},{"key":"B645","doi-asserted-by":"publisher","DOI":"10.3390\/biology10040278"},{"key":"B646","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311003"},{"key":"B647","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD001127.pub3"},{"key":"B648","doi-asserted-by":"publisher","DOI":"10.1378\/chest.113.5.1329"},{"key":"B649","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.122695"},{"key":"B650","doi-asserted-by":"publisher","DOI":"10.1038\/mi.2016.27"},{"key":"B651","volume-title":"Rheology Principles, Measurements, and Applications","author":"Macosko CW","year":"1994"},{"key":"B652","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2008.09.008"},{"key":"B653","doi-asserted-by":"publisher","DOI":"10.1007\/s003970000094"},{"key":"B654","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.2016.1158716"},{"key":"B655","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2022.04.008"},{"key":"B656","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2021-0359OC"},{"key":"B657","doi-asserted-by":"publisher","DOI":"10.1164\/arrd.1977.115.6.989"}],"container-title":["Physiological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physrev.00004.2021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:08:43Z","timestamp":1700064523000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physrev.00004.2021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,1]]},"references-count":656,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10,1]]}},"alternative-id":["10.1152\/physrev.00004.2021"],"URL":"https:\/\/doi.org\/10.1152\/physrev.00004.2021","relation":{},"ISSN":["0031-9333","1522-1210"],"issn-type":[{"value":"0031-9333","type":"print"},{"value":"1522-1210","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,1]]},"assertion":[{"value":"2021-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-13","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}