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Despite that, the CNS provides both sympathetic and parasympathetic inputs to the GI tract, which confers an additional layer of regulation, modulation, and integration over GI functions. The sympathetic nervous system provides neurovascular control of GI blood flow in addition to its effects to decrease mucosal secretion, regulate sphincter tone, and modulate motility, principally via prejunctional and presynaptic actions. The parasympathetic nervous system, however, exerts both excitatory and inhibitory effects; the extent to which this influences gut functions varies throughout the length of the GI tract. Recent studies have also demonstrated that, in addition to regulation via the autonomic nervous system, \u201chigher\u201d CNS nuclei also provide a significant degree of influence over GI functions under both physiological and pathophysiological conditions. 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