{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T12:51:21Z","timestamp":1790254281700,"version":"4.1.0"},"reference-count":208,"publisher":"American Physiological Society","issue":"3","funder":[{"name":"NIH\/NIAMS","award":["AR053293"],"award-info":[{"award-number":["AR053293"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Reviews"],"published-print":{"date-parts":[[2017,7,1]]},"abstract":"<jats:p>The identification of the low-density lipoprotein receptor (LDLR) provided a foundation for subsequent studies in lipoprotein metabolism, receptor-mediated endocytosis, and many other fundamental biological functions. The importance of the LDLR led to numerous studies that identified homologous molecules and ultimately resulted in the description of the LDL-receptor superfamily, a group of proteins that contain domains also found in the LDLR. Subsequent studies have revealed that members of the LDLR-related protein family play roles in regulating many aspects of signal transduction. This review is focused on the roles of selected members of this protein family in skeletal development and disease. We present background on the identification of this subgroup of receptors, discuss the phenotypes associated with alterations in their function in human patients and mouse models, and describe the current efforts to therapeutically target these proteins to treat human skeletal disease.<\/jats:p>","DOI":"10.1152\/physrev.00013.2016","type":"journal-article","created":{"date-parts":[[2017,6,15]],"date-time":"2017-06-15T00:25:25Z","timestamp":1497486325000},"page":"1211-1228","source":"Crossref","is-referenced-by-count":35,"title":["Low-Density Lipoprotein Receptor-Related Proteins in Skeletal Development and Disease"],"prefix":"10.1152","volume":"97","author":[{"given":"Tao","family":"Yang","sequence":"first","affiliation":[{"name":"Program in Skeletal Disease and Tumor Microenvironment, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart O.","family":"Williams","sequence":"additional","affiliation":[{"name":"Program in Skeletal Disease and Tumor Microenvironment, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.13.3797"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.12.4946-4955.2005"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2004.02.018"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.22101"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1038\/ng1257"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2003.18.6.960"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.42.30087"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M011437200"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.07.002"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.22318"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R300017-JLR200"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2005.03.007"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-353"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.04.035"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1513724"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1126\/science.1082095"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000448"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013444"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25179"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.76.7.3330"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9061"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.098889"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1413828111"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2011.07.004"},{"key":"B24a","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1998.5688"},{"key":"B25","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1016\/S0021-9258(19)39742-X","volume":"265","author":"Chen WJ","year":"1990","journal-title":"J Biol Chem"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.09.016"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.0040249"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0007930"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2011.11.023"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3697"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2388"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.14.6334"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nm1538"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.24576"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1757"},{"key":"B35a","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9545"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1126\/stke.3642006cm7"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.164"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207316"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1007428107"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp051726"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.2741\/3882"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-11-191577"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI32371"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-12-127613"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.269639"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.R800058-JLR200"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2005.02.017"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1177\/1759720X12448454"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.03.004"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0b013e328349c2b1"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.108.179564"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0012682"},{"key":"B52a","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(01)00571-2"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0410220"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1210\/me.2003-0456"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.03.002"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081104"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135342"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90511-A"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb03306.x"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1990.tb08301.x"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(03)00073-4"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-1119(98)00311-4"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80861-2"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070330"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198709173171204"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.040907"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204989200"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501900200"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1042\/bj3640323"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1423533112"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.06.055"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.439"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.324673"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.10.4431"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.061118"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-2126(03)00010-8"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/88556"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.08.020"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2006.08.005"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2012.10.003"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2013.05.019"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3987-12.2012"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2014.00246"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/ng2063"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.35920"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0010418"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200201089"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2006.04.109"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.101956"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1210\/er.2011-1060"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3006627"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01137"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2008.02.007"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2013.04.007"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.jbchem.a022223"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.007"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2012.12.004"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.029"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3698"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1021\/bi011344k"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01405"},{"key":"B102","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1002\/jor.21078","volume":"28","author":"Komatsu DE","year":"2010","journal-title":"J Orthop Res"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.15.5810"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2009.12.002"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.080512"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2006.12.009"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1016\/S1091-8531(03)00051-X"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2086"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.070804"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.190330"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1517\/14712598.2012.740006"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2010.03.004"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0103250"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2005.01371.x"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvw205"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36647"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1086\/338450"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2014.162"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00501.2015"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kes178"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2016.02.020"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a008334"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023537"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-012-9689-z"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515480113"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.4061\/2010\/460120"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.4248\/BR201301004"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M305858200"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2003.00086_4_5.x"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5231-z"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305224"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2007.04447.x"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.20400"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118475"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1038\/nrg1427"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1002\/ar.a.20016"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvs126"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210054"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041102"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2011.07.015"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2012.05.023"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1021\/bi992087a"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80655-8"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0004092"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.33372"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.140419"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.323600"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000260204.40510.aa"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1038\/35035124"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.265413"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118636"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a007997"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063323"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1038\/ng.446"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-014-7520-7"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.26.2.605-616.2006"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1038\/ng1196-357"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M601000200"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.041101"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-003-2183-Z"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-169508"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(98)80035-5"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2015.05.012"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1186\/ar4466"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1152\/physiol.00061.2014"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.071113"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.25.14863"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01580"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1126\/science.2988123"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2015.00054"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21062"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.11.034"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1038\/35035117"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1002\/art.39179"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M806538200"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00214-4"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2004.10.038"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-6374fje"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600756"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(03)00266-1"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05914"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.05.017"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1016\/S1063-4584(03)00170-5"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02696"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac4351"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1038\/35035110"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081235"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.16.8460"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/cdg599"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2098"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.09.059"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.545376"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2471"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-014-0076-2"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27082"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2160"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.1661"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1002\/jbmr.2116"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.11.4677-4684.2004"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2013.01.033"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.23324"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1120407109"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.116.307736"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07002.x"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.1164263"}],"container-title":["Physiological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physrev.00013.2016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T18:03:53Z","timestamp":1659117833000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physrev.00013.2016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,1]]},"references-count":208,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,7,1]]}},"alternative-id":["10.1152\/physrev.00013.2016"],"URL":"https:\/\/doi.org\/10.1152\/physrev.00013.2016","relation":{},"ISSN":["0031-9333","1522-1210"],"issn-type":[{"value":"0031-9333","type":"print"},{"value":"1522-1210","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,1]]}}}