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It started by the discovery of endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S production in mammalian cells and gained momentum by typifying this gasotransmitter with a variety of physiological functions. The H\n                    <jats:sub>2<\/jats:sub>\n                    S-catalyzing enzymes are differentially expressed in cardiovascular, neuronal, immune, renal, respiratory, gastrointestinal, reproductive, liver, and endocrine systems and affect the functions of these systems through the production of H\n                    <jats:sub>2<\/jats:sub>\n                    S. The physiological functions of H\n                    <jats:sub>2<\/jats:sub>\n                    S are mediated by different molecular targets, such as different ion channels and signaling proteins. Alternations of H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolism lead to an array of pathological disturbances in the form of hypertension, atherosclerosis, heart failure, diabetes, cirrhosis, inflammation, sepsis, neurodegenerative disease, erectile dysfunction, and asthma, to name a few. Many new technologies have been developed to detect endogenous H\n                    <jats:sub>2<\/jats:sub>\n                    S production, and novel H\n                    <jats:sub>2<\/jats:sub>\n                    S-delivery compounds have been invented to aid therapeutic intervention of diseases related to abnormal H\n                    <jats:sub>2<\/jats:sub>\n                    S metabolism. While acknowledging the challenges ahead, research on H\n                    <jats:sub>2<\/jats:sub>\n                    S physiology and medicine is entering an exponential exploration era.\n                  <\/jats:p>","DOI":"10.1152\/physrev.00017.2011","type":"journal-article","created":{"date-parts":[[2012,4,25]],"date-time":"2012-04-25T04:30:30Z","timestamp":1335328230000},"page":"791-896","source":"Crossref","is-referenced-by-count":1819,"title":["Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed"],"prefix":"10.1152","volume":"92","author":[{"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biology, Lakehead University, Thunder Bay, Ontario, 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