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This progress has also underpinned novel approaches to treatment which, in at least some patients, can be of considerable therapeutic benefit.\n                  <\/jats:p>","DOI":"10.1152\/physrev.00032.2020","type":"journal-article","created":{"date-parts":[[2020,12,24]],"date-time":"2020-12-24T11:52:31Z","timestamp":1608810751000},"source":"Crossref","is-referenced-by-count":44,"title":["Lipodystrophy: A paradigm for understanding the consequences of \"overloading\" adipose tissue"],"prefix":"10.1152","author":[{"given":"Koini","family":"Lim","sequence":"first","affiliation":[{"name":"University of Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afreen","family":"Haider","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, University of Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Adams","sequence":"additional","affiliation":[{"name":"University of Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Sleigh","sequence":"additional","affiliation":[{"name":"University of Cambridge"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Savage","sequence":"additional","affiliation":[{"name":"Clinical Biochemistry, University of Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","published-online":{"date-parts":[[2020,12,24]]},"reference":[{"key":"p_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118083"},{"key":"p_5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.06.030"},{"key":"p_16","doi-asserted-by":"crossref","first-page":"4708","DOI":"10.1073\/pnas.88.11.4708","volume":"88","journal-title":"Proc Natl Acad Sci U S A"},{"key":"p_18","volume":"3277","author":"Acosta JR","journal-title":"Laurencikiene J."},{"key":"p_20","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1007\/s00125-015-3810-6","volume":"59","year":"2016","journal-title":"Diabetologia"},{"key":"p_25","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.22.53"},{"key":"p_28","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.26.99"},{"key":"p_31","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1111\/jocn.14342","volume":"27","year":"2018","journal-title":"J Clin Nurs"},{"key":"p_36","first-page":"3149","volume":"12","year":"1997","journal-title":"J Clin Invest"},{"key":"p_43","doi-asserted-by":"publisher","DOI":"10.1038\/ng880"},{"key":"p_44","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddg213"},{"key":"p_50","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-0123"},{"key":"p_54","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2003-030855"},{"key":"p_59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.250449"},{"key":"p_64","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.ajhg.2010.10.031","volume":"87","journal-title":"Am J Hum Genet"},{"key":"p_69","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.2337\/db17-1236","volume":"67","year":"2018","journal-title":"Diabetes"},{"key":"p_75","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.09.003"},{"key":"p_78","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12967-015-0757-9","volume":"14","year":"2016","journal-title":"J Transl Med"},{"key":"p_83","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.metabol.2018.10.004","volume":"90","year":"2019","journal-title":"Metabolism"},{"key":"p_86","first-page":"2703","volume":"152","journal-title":"Am J Med Genet Part A"},{"key":"p_89","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.02.012"},{"key":"p_93","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13311"},{"key":"p_104","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2016-1005"},{"key":"p_107","volume":"3369","author":"Bradt P","journal-title":"Brown RJ."},{"key":"p_109","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02730"},{"key":"p_113","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2016.05.001"},{"key":"p_118","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1038\/ejhg.2012.77","volume":"20","journal-title":"Eur J Hum Genet"},{"key":"p_122","unstructured":"altered in vitro expression and partial lipodystrophy. 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