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Finally, neuromuscular activity and muscle mass have a major impact on metabolic properties of the organisms. This review discusses the mechanisms involved in the development and maintenance of the neuromuscular junction, the consequences of and the mechanisms involved in its dysfunction, and its role in maintaining muscle mass during aging. As life expectancy is increasing, loss of muscle mass during aging, called sarcopenia, has emerged as a field of high medical need. Interestingly, aging is also accompanied by structural changes at the neuromuscular junction, suggesting that the mechanisms involved in neuromuscular junction maintenance might be disturbed during aging. In addition, there is now evidence that behavioral paradigms and signaling pathways that are involved in longevity also affect neuromuscular junction stability and sarcopenia.<\/jats:p>","DOI":"10.1152\/physrev.00033.2014","type":"journal-article","created":{"date-parts":[[2015,6,25]],"date-time":"2015-06-25T01:26:34Z","timestamp":1435195594000},"page":"809-852","source":"Crossref","is-referenced-by-count":440,"title":["Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting"],"prefix":"10.1152","volume":"95","author":[{"given":"Lionel A.","family":"Tintignac","sequence":"first","affiliation":[{"name":"Biozentrum, University of Basel, Basel, Switzerland; Department of Biomedicine, University of Basel, Basel, Switzerland; and INRA, UMR866 Dynamique Musculaire et M\u00e9tabolisme, Montpellier, 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