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A byproduct of peroxisomal metabolism is the generation, and subsequent detoxification, of reactive oxygen and nitrogen species, particularly hydrogen peroxide (H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    ). Because of its relatively low reactivity (as a mild oxidant), H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    has a comparatively long intracellular half-life and a high diffusion rate, all of which makes H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    an efficient signaling molecule. Peroxisomes also have intricate connections to mitochondria, and both organelles appear to play important roles in regulating redox signaling pathways. Peroxisomal proteins are also subject to oxidative modification and inactivation by the reactive oxygen and nitrogen species they generate, but the peroxisomal LonP2 protease can selectively remove such oxidatively damaged proteins, thus prolonging the useful lifespan of the organelle. Peroxisomal homeostasis must adapt to the metabolic state of the cell, by a combination of peroxisome proliferation, the removal of excess or badly damaged organelles by autophagy (pexophagy), as well as by processes of peroxisome inheritance and motility. More recently the tumor suppressors ataxia telangiectasia mutate (ATM) and tuberous sclerosis complex (TSC), which regulate mTORC1 signaling, have been found to regulate pexophagy in response to variable levels of certain reactive oxygen and nitrogen species. It is now clear that any significant loss of peroxisome homeostasis can have devastating physiological consequences. Peroxisome dysregulation has been implicated in several metabolic diseases, and increasing evidence highlights the important role of diminished peroxisomal functions in aging processes.\n                  <\/jats:p>","DOI":"10.1152\/physrev.00033.2016","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T08:55:18Z","timestamp":1511340918000},"page":"89-115","source":"Crossref","is-referenced-by-count":134,"title":["Redox Regulation of Homeostasis and Proteostasis in Peroxisomes"],"prefix":"10.1152","volume":"98","author":[{"given":"Cheryl L.","family":"Walker","sequence":"first","affiliation":[{"name":"Center for Precision Environmental Health and Departments of Molecular &amp; Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas; and Leonard Davis School of Gerontology of the Ethel Percy Andrus Gerontology Center and Division of Molecular &amp; Computational Biology, Department of Biological Sciences of the Dornsife College of Letters, Arts, and Sciences, The University of Southern California, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C. 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