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The two members, ryanodine receptors (RyRs) and inositol-1,4,5-trisphosphate receptors (IP<jats:sub>3<\/jats:sub>Rs), are evolutionarily related and are both activated by cytosolic Ca<jats:sup>2+<\/jats:sup>. They share a common architecture, but RyRs have evolved additional modules in the cytosolic region. Their massive size allows for the regulation by tens of proteins and small molecules, which can affect the opening and closing of the channels. In addition to Ca<jats:sup>2+<\/jats:sup>, other major triggers include IP<jats:sub>3<\/jats:sub> for the IP<jats:sub>3<\/jats:sub>Rs and depolarization of the plasma membrane for a particular RyR subtype expressed in skeletal muscle. Their size has made them popular targets for study via electron microscopic methods, with current structures culminating near 3\u2009\u00c5. The available structures have provided many new mechanistic insights into the binding of auxiliary proteins and small molecules, how these can regulate channel opening, and the mechanisms of disease-associated mutations. They also help scrutinize previously proposed binding sites, as some of these are now incompatible with the structures. Many questions remain around the structural effects of posttranslational modifications, additional binding partners, and the higher order complexes these channels can make in situ. 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