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The aim of this review is to summarize and synthesize basic information and recent advances in the understanding of the properties of the detrusor smooth muscle, its contractile system, cellular signaling, membrane properties, and cellular receptors. Alterations in these systems in pathological conditions of the bladder wall are described, and some areas for future research are suggested.<\/jats:p>","DOI":"10.1152\/physrev.00038.2003","type":"journal-article","created":{"date-parts":[[2004,7,21]],"date-time":"2004-07-21T14:12:51Z","timestamp":1090419171000},"page":"935-986","source":"Crossref","is-referenced-by-count":816,"title":["Urinary Bladder Contraction and Relaxation: Physiology and Pathophysiology"],"prefix":"10.1152","volume":"84","author":[{"given":"Karl-Erik","family":"Andersson","sequence":"first","affiliation":[{"name":"Departments of Clinical Pharmacology and Physiological Sciences, University of Lund, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Arner","sequence":"additional","affiliation":[{"name":"Departments of Clinical Pharmacology and Physiological Sciences, University of Lund, Lund, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"R1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)61998-0"},{"key":"R2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)64635-6"},{"key":"R3","doi-asserted-by":"publisher","DOI":"10.1002\/nau.10052"},{"key":"R4","doi-asserted-by":"crossref","unstructured":"Adam LP\n , Haeberle JR, and Hathaway DR.\n Phosphorylation of caldesmon in arterial smooth muscle.\n J Biol Chem\n 264\n : 7698\u20137703, 1989.","DOI":"10.1016\/S0021-9258(18)83291-4"},{"key":"R5","unstructured":"Adelstein RS\n and Sellers JR.\n Myosin structure and function. 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