{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T22:17:28Z","timestamp":1791584248344,"version":"4.3.4"},"reference-count":310,"publisher":"American Physiological Society","issue":"4","funder":[{"DOI":"10.13039\/501100008385","name":"Fondazione per la Ricerca sulla Fibrosi Cistica","doi-asserted-by":"publisher","award":["Project FFC#4\/2022"],"award-info":[{"award-number":["Project FFC#4\/2022"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["133351"],"award-info":[{"award-number":["133351"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"HHS | NIH | National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["176537"],"award-info":[{"award-number":["176537"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["journals.physiology.org"],"crossmark-restriction":true},"short-container-title":["Physiological Reviews"],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:p>Representing severe morbidity and mortality globally, respiratory infections associated with chronic respiratory diseases, including complicated pneumonia, asthma, interstitial lung disease, and chronic obstructive pulmonary disease, are a major public health concern. Lung health and the prevention of pulmonary disease rely on the mechanisms of airway surface fluid secretion, mucociliary clearance, and adequate immune response to eradicate inhaled pathogens and particulate matter from the environment. The antimicrobial proteins and peptides contribute to maintaining an antimicrobial milieu in human lungs to eliminate pathogens and prevent them from causing pulmonary diseases. The predominant antimicrobial molecules of the lung environment include human \u03b1- and \u03b2-defensins and cathelicidins, among numerous other host defense molecules with antimicrobial and antibiofilm activity such as PLUNC (palate, lung, and nasal epithelium clone) family proteins, elafin, collectins, lactoferrin, lysozymes, mucins, secretory leukocyte proteinase inhibitor, surfactant proteins SP-A and SP-D, and RNases. It has been demonstrated that changes in antimicrobial molecule expression levels are associated with regulating inflammation, potentiating exacerbations, pathological changes, and modifications in chronic lung disease severity. Antimicrobial molecules also display roles in both anticancer and tumorigenic effects. Lung antimicrobial proteins and peptides are promising alternative therapeutics for treating and preventing multidrug-resistant bacterial infections and anticancer therapies.<\/jats:p>","DOI":"10.1152\/physrev.00039.2023","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T10:56:59Z","timestamp":1721905019000},"page":"1643-1677","update-policy":"https:\/\/doi.org\/10.1152\/aps-crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Lung antimicrobial proteins and peptides: from host defense to therapeutic strategies"],"prefix":"10.1152","volume":"104","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2028-2087","authenticated-orcid":false,"given":"Yuanpu Peter","family":"Di","sequence":"first","affiliation":[{"name":"Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9771-3784","authenticated-orcid":false,"given":"Jenna Marie","family":"Kuhn","sequence":"additional","affiliation":[{"name":"Department of Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5991-5868","authenticated-orcid":false,"given":"Maria Luisa","family":"Mangoni","sequence":"additional","affiliation":[{"name":"Department of Biochemical Sciences, Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, Sapienza University of Rome, Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","first-page":"1","volume":"456","author":"Xu J","year":"2022","journal-title":"NCHS Data Brief"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1088\/1752-7163\/ac2589"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1353"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.29"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00342"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00009.2015"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111691"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1016\/bs.abr.2020.09.011"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.3201\/eid2305.161556"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1126\/science.1159483"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1128\/am.8.1.46-51.1960"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.3389\/bjbs.2023.11387"},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S287792"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1038\/s41570-021-00313-1"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222011172"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.00911"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.4103\/jpbs.JPBS_753_20"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2009.02.037"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1084\/jem.70.1.1"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1038\/292246a0"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.15.5449"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nri1180"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1111\/pai.12079"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2016.00309"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199906000-00001"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/nri3228"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.aninu.2020.09.002"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.jprot.2017.02.016"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1086\/648408"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0704380"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-010-1022-4"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1159\/000336619"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2546"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.570296"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0325z.x"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2012.11.009"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.68.1.9"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1089\/AID.2013.0279"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1042\/bj3260039"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)68522-9"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1177\/00220345900690010101"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200206000-00002"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-7-29"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.165.7.200110-020"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.2217\/fmb.15.151"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000639"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2016.02.072"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro2836"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.006819"},{"key":"B50","first-page":"3919","volume":"11","author":"Lei J","year":"2019","journal-title":"Am J Transl Res"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0282(2000)55:1<4::AID-BIP30>3.3.CO;2-D"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.04.012"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.11.002"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2011.01082.x"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2017.00045"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.2174\/1389203043379459"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.451047"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.2174\/092986706776055689"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2014.12.012"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1021\/acs.langmuir.0c02306"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1177\/1753425910365734"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01553-x"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.178.12.8046"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/j.pupt.2005.01.001"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.176.4.2455"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1042\/BST0391012"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009098"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1042\/BST0391051"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2013.01.050"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202340"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2011.01.026"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001769"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00507-2020"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701126R"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.622598"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-021-01738-4"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra022387"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.60.041807.123500"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nri1528"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2021.01.005"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1988.tb02819.x"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2015.12.001"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3390\/molecules16086992"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.3390\/nu14153090"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1023\/b:biom.0000027691.86757.e2"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/417552a"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.0c00050"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00500-13"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-010-0015-5"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics10121534"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006512"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2015.11.004"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2023.07.016"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.07.014"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.582779"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2008.12.003"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2020.12.016"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.3390\/biom8010004"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.24.14421"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/s0005-2736(99)00208-4"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1267"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1007\/82_2015_5021"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.2174\/1568026615666150703121700"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpc.2021.106721"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0606129103"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1021\/bi9620621"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1021\/bi0267846"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2022.184047"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194877"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00534-18"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1021\/bi0012843"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1021\/bi002656a"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-021-00343-2"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1817352116"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.12659\/msm.902095"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2019.05.014"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.03.004"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00688-09"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S215070"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249552"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1039\/c4sm00907j"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1093\/femsre\/fuz026"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1126\/science.1218831"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20031975"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14940"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2014364118"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1007\/s42770-021-00624-x"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222111401"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00318-08"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2009.08.017"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.62.081307.162903"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004152"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2017.01867"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.3390\/biom10040652"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.03.077"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00888-13"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1291-7"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1016\/j.tvjl.2019.05.006"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3534"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.02367-17"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.2174\/157016207781023947"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.045013-0"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.3.1763"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.12.1345"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.3390\/v11080704"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.10.5147-5156.2004"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1007\/s100960050457"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.12.8658"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.01155"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-101416-041734"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202001885RR"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00321"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04462-6"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1128\/EC.00095-14"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-013-1500-4"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116345"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1128\/iai.59.8.2549-2554.1991"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.09.119"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.3390\/jof6030124"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.3390\/microorganisms10071437"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2016.04.027"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2019.02573"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1358\/dof.2010.035.03.1452077"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.6.2935"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.1997.272.5.L888"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00056-05"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140778"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1393"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.03.006"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.0c01321"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2021.152128"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.11.007"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03656-y"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.71.110601.135414"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1021\/bi035130+"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00534-10"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504327200"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-015-2041-y"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2009.04.021"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1128\/cdli.9.5.972-982.2002"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-017-1555-z"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5008"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8392523"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.02.007"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1111\/exd.12929"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.2119\/2008-00002.Steinstraesser"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2009.284"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700599"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-55426-x"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1007\/s10482-017-0929-0"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2009.03893.x"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00037-15"},{"key":"B193","unstructured":"Jain H, Schweitzer JW, Justice NA. Respiratory syncytial virus infection in children. In:\n                      StatPearls\n                      . Treasure Island, FL: StatPearls Publishing, 2023."},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584801"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.09.038"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-8244(03)00106-8"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.2741\/s83"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.6.3995"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-007-9659-3"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013224"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1111\/pan.14382"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(22)00445-5"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01016-9"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.102681"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2014.86"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.3233\/DMA-2011-0807"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2760"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.344.13951"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2003.12.008"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(89)90186-1"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198210000-00014"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200301-005OC"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2014.09.003"},{"key":"B214","first-page":"38","volume":"21","author":"Vega A","year":"2011","journal-title":"J Investig Allergol Clin Immunol"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1111\/cea.12313"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1111\/all.12087"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14118"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1007\/BF02714163"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1159\/000070744"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1172\/JCI80911"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2020.152025"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.7150\/thno.30726"},{"key":"B223","first-page":"4051","volume":"24","author":"Arimura Y","year":"2004","journal-title":"Anticancer Res"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1002\/path.1726"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2017.10.025"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2008.00772.x"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.751232"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212895"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1177\/1753425913508992"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1016\/j.tube.2021.102080"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.4238\/2013.October.24.2"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-6-130"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0240012"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1055\/s-0036-1584923"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004360"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cix483"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1093\/femspd\/ftaa048"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2021.747834"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201812-2303LE"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20092128"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0033601"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.09.013"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.09.009"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2022.12.050"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)00470-6"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064689"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2002-0267OC"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.2.651"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.163.2.947"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.07.008"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)61380-3"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214185"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1016\/s0006-2952(03)00292-2"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1159\/000490183"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1007\/s00005-015-0359-5"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.09.008"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.25489"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22026"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1532\/ijh97.a10407"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2013.248"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2023.1183247"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2020.07.004"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-022-00821-x"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.15698\/mic2021.02.741"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2018.10.019"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.4110\/in.2021.21.e19"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201607-1408OC"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0016384"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1586\/ers.13.24"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.1096\/fj.00-0865fje"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1085551"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0262082"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222449"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.173.5.2909"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1097\/moh.0b013e32831ac517"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8349712"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-156-2-201201170-00004"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01405-0"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12588"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S333039"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-022-01362-4"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0212628"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav3879"},{"key":"B284","volume":"44","author":"Ms A","year":"2014","journal-title":"Eur Respir J"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1038\/nrmicro.2016.142"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20200426"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1186\/s40168-023-01673-0"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1038\/s41522-022-00332-w"},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1590\/0037-8682-0461-2021"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1039\/d1cs90109e"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9030128"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aay6817"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1021\/jm1012853"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-016-2341-x"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-017-3705-2"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2020.1819258"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00303"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020339"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2006.02.021"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2018.03.006"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2019.12.019"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901896RR"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbpa.2008.03.009"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.2c00138"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112297"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-021-04030-2"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.00226-19"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2019.11.012"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1007\/s12195-020-00626-z"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1021\/bi701850m"}],"container-title":["Physiological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physrev.00039.2023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T09:52:12Z","timestamp":1725443532000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physrev.00039.2023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":310,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,10,1]]}},"alternative-id":["10.1152\/physrev.00039.2023"],"URL":"https:\/\/doi.org\/10.1152\/physrev.00039.2023","relation":{},"ISSN":["0031-9333","1522-1210"],"issn-type":[{"value":"0031-9333","type":"print"},{"value":"1522-1210","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,1]]},"assertion":[{"value":"2023-12-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-11","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}