{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:21:42Z","timestamp":1793384502544,"version":"4.5.0"},"reference-count":333,"publisher":"American Physiological Society","issue":"1","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1158 B01"],"award-info":[{"award-number":["SFB1158 B01"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1158 B06"],"award-info":[{"award-number":["SFB1158 B06"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB1158 B08"],"award-info":[{"award-number":["SFB1158 B08"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008316","name":"Baden W\u00fcrttemberg Foundation","doi-asserted-by":"crossref","award":["Internationale Spitzenf\u00f6rderung"],"award-info":[{"award-number":["Internationale Spitzenf\u00f6rderung"]}],"id":[{"id":"10.13039\/100008316","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Reviews"],"published-print":{"date-parts":[[2021,1,1]]},"abstract":"<jats:p> Chronic, pathological pain remains a global health problem and a challenge to basic and clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been that the nature of neural circuits underlying the diverse components of the complex, multidimensional experience of pain is not well understood. Moreover, chronic pain involves diverse maladaptive plasticity processes, which have not been decoded mechanistically in terms of involvement of specific circuits and cause-effect relationships. This review aims to discuss recent advances in our understanding of circuit connectivity in the mammalian brain at the level of regional contributions and specific cell types in acute and chronic pain. A major focus is placed on functional dissection of sub-neocortical brain circuits using optogenetics, chemogenetics, and imaging technological tools in rodent models with a view towards decoding sensory, affective, and motivational-cognitive dimensions of pain. The review summarizes recent breakthroughs and insights on structure-function properties in nociceptive circuits and higher order sub-neocortical modulatory circuits involved in aversion, learning, reward, and mood and their modulation by endogenous GABAergic inhibition, noradrenergic, cholinergic, dopaminergic, serotonergic, and peptidergic pathways. The knowledge of neural circuits and their dynamic regulation via functional and structural plasticity will be beneficial towards designing and improving targeted therapies. <\/jats:p>","DOI":"10.1152\/physrev.00040.2019","type":"journal-article","created":{"date-parts":[[2020,6,11]],"date-time":"2020-06-11T20:09:23Z","timestamp":1591906163000},"page":"213-258","source":"Crossref","is-referenced-by-count":343,"title":["Cellular Circuits in the Brain and Their Modulation in Acute and Chronic Pain"],"prefix":"10.1152","volume":"101","author":[{"given":"Rohini","family":"Kuner","sequence":"first","affiliation":[{"name":"Institute of Pharmacology, Heidelberg University, Heidelberg, Germany; and Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Kuner","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Heidelberg University, Heidelberg, Germany; and Department of Functional Neuroanatomy, Institute for Anatomy and Cell Biology, Heidelberg University, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0354-y"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1364\/OE.23.028191"},{"key":"B3","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2012.06.033"},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.6512-10.2011"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2016.11.005"},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142919"},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.08.010"},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1038\/srep15419"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109111108"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000332"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2541-04.2004"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000460818.62406.38"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.02.153"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2000.0582"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.08.040"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0483-18.2018"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.06.005"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1038\/srep06186"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3576-06.2006"},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106133"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3153"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.09.028"},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv106"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23310"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00052.2017"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903290205"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.04.020"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.68"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/123.3.601"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001275"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/boc.201600040"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.09.041"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.03.049"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.06.021"},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.01268"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.01.018"},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22003"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1038\/nature02266"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2015.00135"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2007.06.010"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1333-16.2016"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1097\/01.j.pain.0000460347.77341.bd"},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3516"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-10-70"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14146"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.1038\/nature25511"},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2013.01.021"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5197-12.2013"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07721.x"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.003"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.02.019"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001497"},{"key":"B55","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2016.00028"},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.009"},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1807991115"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1186\/s10194-017-0747-9"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000942"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2731-17.2018"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.586"},{"key":"B62","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.11-03-00852.1991"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(86)90457-X"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.2"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1176-7"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0799-15.2015"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1126\/science.aap8586"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1038\/372770a0"},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.173"},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13103"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902920106"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1097\/PR9.0000000000000732"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-019-0435-6"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4335"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22392"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.122"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1996.75.3.1026"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.11.005"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4091"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-010-0002-4"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3628"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1126\/science.2321027"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.02.001"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1480-08.2008"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1016\/j.ynstr.2018.06.002"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.08.046"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3398-09.2009"},{"key":"B88","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00349"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.01.041"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1093\/pm\/pny008"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2916-15.2015"},{"key":"B92","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113817"},{"key":"B93","doi-asserted-by":"publisher","DOI":"10.1126\/science.1258477"},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2019.00715"},{"key":"B95","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1991"},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.008"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1126\/science.1174521"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.09.022"},{"key":"B99","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.08.013"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2017.10.007"},{"key":"B101","first-page":"95","volume-title":"Headache and Pain","author":"Garcia-Larrea L","year":"2013"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.09.001"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2016.11.011"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.1694"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21545"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan2475"},{"key":"B107","volume-title":"The Mesolimbic Dopamine System: From Motivation to Action","author":"Groenewegen HJ","year":"1991"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1554-08.2008"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.09.042"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117746"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5980-10.2011"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-02957-9"},{"key":"B113","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-12-41"},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.06.005"},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-6-10"},{"key":"B116","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4112-05.2005"},{"key":"B117","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.05.057"},{"key":"B118","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/34.2-3.102"},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-015-1161-1"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0174-13.2013"},{"key":"B121","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpain.2019.04.002"},{"key":"B122","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2006.01.005"},{"key":"B123","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4835-13.2014"},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014111"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.29808"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2671-11.2011"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2009.89"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1126\/science.1255263"},{"key":"B129","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2016.01.004"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0481-5"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2014.12.024"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-019-03003-z"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3780"},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1038\/srep29480"},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-6-59"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60805-4"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70102-4"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0225-10.2010"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8924"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-04060-6"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001240"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(03)45011-5"},{"key":"B143","volume-title":"The Thalamus","author":"Jones EG","year":"2007"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.2005839"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-cellbio-101011-155833"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0152-4"},{"key":"B147","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-29915-4"},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2016.06.060"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.08.005"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1111\/ner.13059"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2016.00133"},{"key":"B152","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.15"},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1806082115"},{"key":"B154","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0716-07.2007"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4047-15.2016"},{"key":"B156","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00022"},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-022516-034303"},{"key":"B158","doi-asserted-by":"publisher","DOI":"10.1177\/1744806918783478"},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2016.00005"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.06.009"},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.10.042"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1004-18.2018"},{"key":"B163","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.24368"},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.11.006"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2231"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.162"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1038\/nature11527"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.006536"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.02.018"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3494-14.2015"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1993.70.1.200"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1113\/JP276935"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001691"},{"key":"B174","doi-asserted-by":"publisher","DOI":"10.1177\/1744806919832718"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1038\/srep20298"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070921"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.10.013"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2235-16.2016"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.02.018"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2017.00066"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0074533"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.708"},{"key":"B183","doi-asserted-by":"publisher","DOI":"10.1038\/srep34853"},{"key":"B184","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000002137"},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.02.029"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj038"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.03.042"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001375"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.007"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.05.017"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2018.10.019"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.03.054"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.07.007"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19971103)387:4<588:AID-CNE8>3.0.CO;2-Z"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjpain.2015.09.008"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.06.027"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy281"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301393"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0587-12.2012"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4033"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.257428"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.06.071"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2017.08.049"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001167"},{"key":"B205","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2015.09.003"},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000001458"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.063"},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-662-46450-2_13"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108052"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.02.027"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1708361114"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.05.033"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112483"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1177\/1744806917709201"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/12.4.376"},{"key":"B216","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.04.041"},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4183"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4439"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.253823"},{"key":"B220","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.03.007"},{"key":"B221","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19991011)413:1<129:AID-CNE9>3.0.CO;2-Q"},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2016.03.003"},{"key":"B223","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.06.034"},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/60.4.389"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2017.11.005"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.01.067"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.02.006"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2016.12.001"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2017_14"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3629"},{"key":"B231","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4040"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000139"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4281"},{"key":"B234","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1553-16.2017"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5328.968"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.053"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.07.043"},{"key":"B238","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4199"},{"key":"B239","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000000838"},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170529072554"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2029-14.2014"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2014.00088"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbi.2019.01.016"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3381"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.06.003"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3480-15.2016"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.06.008"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0129-16.2017"},{"key":"B249","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.top071795"},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1124\/pr.114.009423"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-19898-5_12"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.04.073"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253994"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3969"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.05.029"},{"key":"B256","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13084"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.01.004"},{"key":"B258","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00012.2012"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-017-0018-8"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2012.03.005"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4269"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00429.2011"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13662"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90678"},{"key":"B265","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-019-0525-y"},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aws153"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000001336"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704302114"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00762.2010"},{"key":"B270","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2019.00168"},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0247-14.2014"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.11.005"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-018-0209-z"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.02.015"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-08873-z"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4645"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.15312"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2019.03.009"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0499-8"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23956"},{"key":"B281","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.09.021"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1364\/OL.28.001022"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2018.11.037"},{"key":"B284","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1928-15.2016"},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1038\/nature17996"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000863"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000499"},{"key":"B288","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.06.033"},{"key":"B289","first-page":"S129","volume":"34","author":"Truini A","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"B290","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000993"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww100"},{"key":"B292","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1818-14.2014"},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv389"},{"key":"B294","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2013.05.052"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.01.038"},{"key":"B296","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2005.086520"},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00014.2018"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1204471"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1177\/1744806916681567"},{"key":"B300","volume-title":"Translational Pain Research: From Mouse to Man","author":"Walton KD","year":"2010"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.23045"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8660"},{"key":"B303","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2014.00112"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20375"},{"key":"B305","doi-asserted-by":"publisher","DOI":"10.1177\/1744806918756406"},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0452-x"},{"key":"B307","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5389-09.2010"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-374236-0.10032-X"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf8934"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1054\/jpai.2002.122949"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.09.011"},{"key":"B312","doi-asserted-by":"publisher","DOI":"10.1126\/science.288.5472.1765"},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2018.10.010"},{"key":"B314","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2020.01.004"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2011.03.007"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.87"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1016\/j.aat.2013.06.011"},{"key":"B318","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2014.08.019"},{"key":"B319","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1676-18.2018"},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1038\/srep41439"},{"key":"B321","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2017.02.1180"},{"key":"B322","doi-asserted-by":"publisher","DOI":"10.1038\/srep45930"},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1999.82.2.1054"},{"key":"B324","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2018.00107"},{"key":"B325","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0066122"},{"key":"B326","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2015.07.001"},{"key":"B327","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00240"},{"key":"B328","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523817000050"},{"key":"B329","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1808622115"},{"key":"B330","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0468-2"},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.003"},{"key":"B332","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.07.013"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.10.012"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2016.223"}],"container-title":["Physiological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/physrev.00040.2019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,4]],"date-time":"2021-05-04T12:43:34Z","timestamp":1620132214000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/physrev.00040.2019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,1]]},"references-count":333,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1,1]]}},"alternative-id":["10.1152\/physrev.00040.2019"],"URL":"https:\/\/doi.org\/10.1152\/physrev.00040.2019","relation":{},"ISSN":["0031-9333","1522-1210"],"issn-type":[{"value":"0031-9333","type":"print"},{"value":"1522-1210","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1,1]]}}}