{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:06:05Z","timestamp":1791050765230,"version":"4.1.0"},"reference-count":420,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Physiological Reviews"],"published-print":{"date-parts":[[1999,1,1]]},"abstract":"<jats:p>Schultz, B.\u2009D., A.\u2009K. Singh, D.\u2009C. Devor, and R.\u2009J. Bridges. Pharmacology of CFTR Chloride Channel Activity. Physiol. Rev. 79, Suppl.: S109\u2013S144, 1999. \u2014 The pharmacology of cystic fibrosis transmembrane conductance regulator (CFTR) is at an early stage of development. Here we attempt to review the status of those compounds that modulate the Cl<jats:sup>\u2212<\/jats:sup>channel activity of CFTR. Three classes of compounds, the sulfonylureas, the disulfonic stilbenes, and the arylaminobenzoates, have been shown to directly interact with CFTR to cause channel blockade. Kinetic analysis has revealed the sulfonylureas and arylaminobenzoates interact with the open state of CFTR to cause blockade. Suggestive evidence indicates the disulfonic stilbenes act by a similar mechanism but only from the intracellular side of CFTR. Site-directed mutagenesis studies indicate the involvement of specific amino acid residues in the proposed transmembrane segment 6 for disulfonic stilbene blockade and segments 6 and 12 for arylaminobenzoate blockade. Unfortunately, these compounds (sulfonylureas, disulfonic stilbenes, arylaminobenzoate) also act at a number of other cellular sites that can indirectly alter the activity of CFTR or the transepithelial secretion of Cl<jats:sup>\u2212<\/jats:sup>. The nonspecificity of these compounds has complicated the interpretation of results from cellular-based experiments. Compounds that increase the activity of CFTR include the alkylxanthines, phosphodiesterase inhibitors, phosphatase inhibitors, isoflavones and flavones, benzimidazolones, and psoralens. Channel activation can arise from the stimulation of the cAMP signal transduction cascade, the inhibition of inactivating enzymes (phosphodiesterases, phosphatases), as well as the direct binding to CFTR. However, in contrast to the compounds that block CFTR, a detailed understanding of how the above compounds increase the activity of CFTR has not yet emerged.<\/jats:p>","DOI":"10.1152\/physrev.1999.79.1.s109","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T20:21:04Z","timestamp":1514146864000},"page":"S109-S144","source":"Crossref","is-referenced-by-count":235,"title":["Pharmacology of CFTR Chloride Channel Activity"],"prefix":"10.1152","volume":"79","author":[{"given":"B. D.","family":"SCHULTZ","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. K.","family":"SINGH","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. C.","family":"DEVOR","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. J.","family":"BRIDGES","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.103.2.153"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1126\/science.7716547"},{"key":"B3","doi-asserted-by":"crossref","first-page":"5592","DOI":"10.1016\/S0021-9258(18)45614-1","volume":"262","author":"AKIYAMA T.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1016\/0076-6879(91)01032-W"},{"key":"B5","first-page":"G204","volume":"273","author":"AL-NAKKASH L.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ph.53.030191.003001"},{"key":"B7","doi-asserted-by":"crossref","first-page":"17092","DOI":"10.1016\/S0021-9258(18)37502-1","volume":"263","author":"ALPER S. L.","year":"1988","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1991.sp018827"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00231887"},{"key":"B10","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90072-7"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1126\/science.1704151"},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1126\/science.1382316"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4889(92)90008-Y"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1159\/000139381"},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/25.10.1950"},{"key":"B17","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1995.sp003854"},{"key":"B18","first-page":"G285","volume":"267","author":"BALLATORI N.","year":"1994","journal-title":"Am. J. Physiol."},{"key":"B19","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/S0026-895X(25)10495-1","volume":"48","author":"BALLATORI N.","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(96)10060-8"},{"key":"B21","doi-asserted-by":"crossref","first-page":"777S","DOI":"10.1093\/jn\/125.3_Suppl.777S","volume":"125","author":"BARNES S.","year":"1995","journal-title":"J. Nutr."},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-208-43840"},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.4.C859"},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.3109\/09687687909063869"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.3109\/09687687909063866"},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90206-2"},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1995.75.4.725"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(93)81016-S"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.19.9160"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.27.16171"},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13850.x"},{"key":"B33","first-page":"G622","volume":"268","author":"BELL C. J.","year":"1995","journal-title":"Am. J. Physiol."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1997.00367.x"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-0813.1946.tb15473.x"},{"key":"B36","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1016\/S0021-9258(18)53959-4","volume":"268","author":"BERGER H. A.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"B37","first-page":"L305","volume":"274","author":"BERGER H. A.","year":"1998","journal-title":"Am. J. Physiol."},{"key":"B38","doi-asserted-by":"publisher","DOI":"10.1007\/BF02207273"},{"key":"B39","doi-asserted-by":"crossref","first-page":"L229","DOI":"10.1152\/ajpcell.1993.264.1.C229","volume":"264","author":"BIJMAN J.","year":"1993","journal-title":"Am. J. Physiol."},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.1.C154"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1968.tb19045.x"},{"key":"B42","first-page":"F498","volume":"271","author":"BOESE S. H.","year":"1996","journal-title":"Am. J. Physiol."},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.4.C1037"},{"key":"B44","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.150.2.8049852"},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1039\/jr9510003447"},{"key":"B47","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021630"},{"key":"B48","first-page":"G325","volume":"264","author":"BRAYDEN D. J.","year":"1993","journal-title":"Am. J. Physiol."},{"key":"B49","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.4.C902"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374375"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050243"},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.1996.tb00084.x"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb13131.x"},{"key":"B54","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169380"},{"key":"B55","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0026-895X(25)09808-6","volume":"46","author":"BUSCH A. E.","year":"1994","journal-title":"Mol. Pharmacol."},{"key":"B56","first-page":"R51","volume":"272","author":"BUTLEN D.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B57","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.4.C803"},{"key":"B58","doi-asserted-by":"publisher","DOI":"10.1007\/BF01867863"},{"key":"B59","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870088"},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870089"},{"key":"B61","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1996.sp003953"},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.4.1711"},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80668-X"},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/55.4.639"},{"key":"B66","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-84-20693"},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900074"},{"key":"B68","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(08)60035-6"},{"key":"B69","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/S0022-3565(25)09564-3","volume":"273","author":"CHALLINOR-ROGERS J. L.","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb07239.x"},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020264"},{"key":"B72","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.5.C1273"},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041640207"},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(96)00132-4"},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13644.x"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6739"},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.5.C1154"},{"key":"B78","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(82)90028-4"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1006\/viro.1994.1641"},{"key":"B80","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1990.tb14728.x"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(79)90334-4"},{"key":"B82","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(96)80049-0"},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.262.3.C783"},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.7.2673"},{"key":"B85","doi-asserted-by":"publisher","DOI":"10.1038\/354526a0"},{"key":"B86","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1996.304"},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1986.tb04348.x"},{"key":"B88","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1542\/peds.41.1.7","volume":"41","author":"DENNING C. R.","year":"1968","journal-title":"Pediatrics"},{"key":"B89","doi-asserted-by":"publisher","DOI":"10.1038\/358761a0"},{"key":"B90","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.1.C70"},{"key":"B91","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.5.C1271"},{"key":"B93","first-page":"L785","volume":"271","author":"DEVOR D. C.","year":"1996","journal-title":"Am. J. Physiol."},{"key":"B94","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.3.C976"},{"key":"B95","first-page":"L775","volume":"271","author":"DEVOR D. C.","year":"1996","journal-title":"Am. J. Physiol."},{"key":"B96","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374290"},{"key":"B97","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00832-2"},{"key":"B98","doi-asserted-by":"publisher","DOI":"10.1177\/030006057900700408"},{"key":"B99","first-page":"G806","volume":"268","author":"DINUDOM A.","year":"1995","journal-title":"Am. J. Physiol."},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1007\/BF00581787"},{"key":"B101","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019082"},{"key":"B102","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2736(88)90466-X"},{"key":"B103","doi-asserted-by":"publisher","DOI":"10.1126\/science.1722350"},{"key":"B104","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.3.C577"},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1007\/BF00169071"},{"key":"B106","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(86)81532-0"},{"key":"B107","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-15-04543.1996"},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328X(94)90203-8"},{"key":"B109","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17171.x"},{"key":"B110","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1993.tb13955.x"},{"key":"B111","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870683"},{"key":"B112","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.12.5562"},{"key":"B113","first-page":"1313","volume":"37","author":"ELENBAAS J. K.","year":"1980","journal-title":"Am. J. Hosp. Pharm."},{"key":"B115","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1977.57.1.71"},{"key":"B116","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0026-895X(25)10232-0","volume":"48","author":"EVANS R. J.","year":"1995","journal-title":"Mol. Pharmacol."},{"key":"B117","doi-asserted-by":"crossref","first-page":"6472","DOI":"10.1016\/S0021-9258(20)82166-8","volume":"259","author":"FALKE J. J.","year":"1984","journal-title":"J. Biol. Chem."},{"key":"B118","doi-asserted-by":"crossref","first-page":"4680","DOI":"10.1016\/S0021-9258(19)85548-5","volume":"255","author":"FARLEY J. R.","year":"1980","journal-title":"J. Biol. Chem."},{"key":"B119","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0004(96)10059-1"},{"key":"B120","doi-asserted-by":"publisher","DOI":"10.1007\/BF01872823"},{"key":"B121","doi-asserted-by":"crossref","first-page":"790S","DOI":"10.1093\/jn\/125.3_Suppl.790S","volume":"125","author":"FOTSIS T.","year":"1995","journal-title":"J. Nutr."},{"key":"B122","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0022-3565(25)38813-0","volume":"236","author":"FOUIN-FORTUNET H.","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B123","first-page":"379","volume":"114","author":"FRANCIA E.","year":"1975","journal-title":"Boll. Chim. Farm."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.2.C747"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.44.26626"},{"key":"B126","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870474"},{"key":"B127","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.3.C827"},{"key":"B128","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233668"},{"key":"B129","first-page":"S183","volume":"44","author":"GADSBY D. C.","year":"1994","journal-title":"Jpn. J. Physiol."},{"key":"B129a","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.S77"},{"key":"B130","doi-asserted-by":"publisher","DOI":"10.1016\/0167-4838(91)90119-K"},{"key":"B131","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.257.6.C1119"},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584943"},{"key":"B133","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583543"},{"key":"B134","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/S0022-3565(25)22638-6","volume":"245","author":"GOMBAR C. T.","year":"1988","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B135","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30048-2"},{"key":"B136","doi-asserted-by":"publisher","DOI":"10.1007\/BF00970734"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1080\/004982597240578"},{"key":"B138","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020761"},{"key":"B139","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.264.3.C591"},{"key":"B140","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1990.259.5.C752"},{"key":"B141","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1983.tb07692.x"},{"key":"B142","doi-asserted-by":"publisher","DOI":"10.1007\/BF00373006"},{"key":"B143","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584833"},{"key":"B144","doi-asserted-by":"publisher","DOI":"10.1007\/BF00583937"},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584757"},{"key":"B146","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.00035.x"},{"key":"B147","doi-asserted-by":"crossref","first-page":"10983","DOI":"10.1016\/S0021-9258(19)78079-X","volume":"269","author":"GRIBKOFF V. K.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/8.4.454"},{"key":"B149","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(83)91220-2"},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(96)04314-5"},{"key":"B151","doi-asserted-by":"publisher","DOI":"10.1021\/bi00028a017"},{"key":"B152","doi-asserted-by":"crossref","first-page":"19349","DOI":"10.1016\/S0021-9258(17)32174-9","volume":"269","author":"GUNDERSON K. L.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90310-0"},{"key":"B155","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.1.C389"},{"key":"B156","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1128\/IAI.63.6.2374-2377.1995","volume":"63","author":"HANAZAWA S.","year":"1995","journal-title":"Infect. Immun."},{"key":"B157","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870801"},{"key":"B158","first-page":"L692","volume":"263","author":"HAWS C.","year":"1992","journal-title":"Am. J. Physiol."},{"key":"B159","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.5.C1544"},{"key":"B160","first-page":"R173","volume":"265","author":"HAYNES J. K.","year":"1993","journal-title":"Am. J. Physiol."},{"key":"B161","doi-asserted-by":"publisher","DOI":"10.1007\/BF00586530"},{"key":"B162","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.32.217"},{"key":"B163","first-page":"F745","volume":"246","author":"HEBERT S. C.","year":"1984","journal-title":"Am. J. Physiol."},{"key":"B164","doi-asserted-by":"publisher","DOI":"10.1007\/BF01868440"},{"key":"B165","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021409"},{"key":"B166","doi-asserted-by":"publisher","DOI":"10.1139\/y91-075"},{"key":"B167","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb14891.x"},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15163.x"},{"key":"B169","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70240-3"},{"key":"B170","doi-asserted-by":"publisher","DOI":"10.1358\/dof.1991.016.06.139960"},{"key":"B171","doi-asserted-by":"publisher","DOI":"10.1021\/jm00171a013"},{"key":"B172","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(96)00776-5"},{"key":"B173","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00744-X"},{"key":"B174","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1113\/jphysiol.1993.sp019743","volume":"466","author":"HUGHES B. A.","year":"1993","journal-title":"J. Physiol. (Lond.)"},{"key":"B175","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117709"},{"key":"B176","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0204"},{"key":"B177","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.101.5.629"},{"key":"B178","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.3.C988"},{"key":"B179","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.6.C1611"},{"key":"B180","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1992.263.3.C674"},{"key":"B181","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.1.C265"},{"key":"B182","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.4.C886"},{"key":"B183","first-page":"L752","volume":"272","author":"ILLEK B.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B185","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80124-5"},{"key":"B186","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1983.tb07357.x"},{"key":"B187","doi-asserted-by":"publisher","DOI":"10.1126\/science.6306765"},{"key":"B188","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.21.11651"},{"key":"B189","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(96)02516-9"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.1.C57"},{"key":"B191","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1993.265.6.C1489"},{"key":"B192","doi-asserted-by":"publisher","DOI":"10.1021\/bi00028a018"},{"key":"B193","doi-asserted-by":"publisher","DOI":"10.1002\/bies.950190206"},{"key":"B194","doi-asserted-by":"publisher","DOI":"10.1021\/jm950661k"},{"key":"B195","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.11013"},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1097\/00001813-199208000-00003"},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118819"},{"key":"B198","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.13.6.7576703"},{"key":"B199","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2604"},{"key":"B200","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020079"},{"key":"B201","doi-asserted-by":"publisher","DOI":"10.1126\/science.2570460"},{"key":"B202","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021666"},{"key":"B203","doi-asserted-by":"publisher","DOI":"10.1016\/S0005-2736(96)00219-2"},{"key":"B204","doi-asserted-by":"publisher","DOI":"10.2337\/diab.44.12.1461"},{"key":"B205","doi-asserted-by":"crossref","first-page":"23475","DOI":"10.1016\/S0021-9258(18)35862-9","volume":"267","author":"KIRK K.","year":"1992","journal-title":"J. Biol. Chem."},{"key":"B206","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.58.2.190"},{"key":"B207","doi-asserted-by":"crossref","first-page":"17274","DOI":"10.1016\/S0021-9258(17)32551-6","volume":"269","author":"KNAUS H. G.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B208","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199108223250802"},{"key":"B209","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021431"},{"key":"B210","doi-asserted-by":"publisher","DOI":"10.1126\/science.273.5282.1709"},{"key":"B211","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.2.C548"},{"key":"B212","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374588"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90615-6"},{"key":"B214","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.261.4.C574"},{"key":"B215","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1992.sp019340"},{"key":"B216","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/S0021-9258(19)40253-6","volume":"265","author":"KUDRYCKI K. E.","year":"1990","journal-title":"J. Biol. Chem."},{"key":"B217","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370589"},{"key":"B218","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(87)90183-3"},{"key":"B219","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979840"},{"key":"B220","doi-asserted-by":"crossref","first-page":"9945","DOI":"10.1016\/S0021-9258(18)82154-8","volume":"268","author":"LEE K.-M.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"B221","first-page":"F594","volume":"269","author":"LEHRICH R. W.","year":"1995","journal-title":"Am. J. Physiol."},{"key":"B222","doi-asserted-by":"publisher","DOI":"10.1007\/BF01868957"},{"key":"B223","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0022-3565(25)25042-X","volume":"238","author":"LETTERON P.","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B224","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900011"},{"key":"B225","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.101.6.801"},{"key":"B226","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.14.5278"},{"key":"B227","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021719"},{"key":"B228","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.2.C628"},{"key":"B229","doi-asserted-by":"publisher","DOI":"10.1136\/gut.38.2.243"},{"key":"B230","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.2.709"},{"key":"B232","doi-asserted-by":"publisher","DOI":"10.1016\/0378-4347(93)80252-Y"},{"key":"B233","doi-asserted-by":"publisher","DOI":"10.1159\/000244026"},{"key":"B234","first-page":"390","volume":"88","author":"MADDY A. H.","year":"1964","journal-title":"Biochim. Biophys. Acta"},{"key":"B235","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00120-X"},{"key":"B236","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.268.1.C191"},{"key":"B237","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.11.3.7916196"},{"key":"B238","first-page":"5111","volume":"49","author":"MARKOVITS J.","year":"1989","journal-title":"Cancer Res."},{"key":"B239","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/S0022-3565(25)23887-3","volume":"235","author":"MATHEWS J. M.","year":"1985","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B240","doi-asserted-by":"publisher","DOI":"10.1016\/0361-9230(84)90163-1"},{"key":"B241","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.4.C1122"},{"key":"B242","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.94.6.1015"},{"key":"B243","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.102.1.1"},{"key":"B244","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/9.6.578"},{"key":"B245","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(94)90030-2"},{"key":"B246","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1994.71.5.1873"},{"key":"B247","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90321-6"},{"key":"B248","doi-asserted-by":"publisher","DOI":"10.1007\/BF01245348"},{"key":"B249","first-page":"291","volume":"255","author":"McMILLIAN M. K.","year":"1988","journal-title":"Biochem. J."},{"key":"B250","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.15.8083"},{"key":"B251","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)92616-4"},{"key":"B252","doi-asserted-by":"publisher","DOI":"10.1055\/s-0028-1111124"},{"key":"B253","doi-asserted-by":"publisher","DOI":"10.1080\/01635589409514310"},{"key":"B254","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90208-Z"},{"key":"B255","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.108.3.177"},{"key":"B257","doi-asserted-by":"publisher","DOI":"10.1007\/BF00170829"},{"key":"B258","first-page":"305","volume":"1","author":"MINTENIG G. M.","year":"1993","journal-title":"Receptors Channels"},{"key":"B259","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.1.C212"},{"key":"B260","doi-asserted-by":"publisher","DOI":"10.1021\/jm00094a013"},{"key":"B261","doi-asserted-by":"publisher","DOI":"10.1042\/bj3220259"},{"key":"B262","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.4.C1041"},{"key":"B263","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1993.73.4.673"},{"key":"B264","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(91)90127-Q"},{"key":"B265","first-page":"G172","volume":"272","author":"NGUYEN T. D.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B266","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050389"},{"key":"B267","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.103.5.787"},{"key":"B268","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1995.sp020886"},{"key":"B269","doi-asserted-by":"publisher","DOI":"10.1007\/BF00724520"},{"key":"B270","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.1939-4640.1994.tb01672.x","volume":"15","author":"OATES R. D.","year":"1994","journal-title":"J. Androl."},{"key":"B271","doi-asserted-by":"publisher","DOI":"10.1007\/BF00686324"},{"key":"B272","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.39.606"},{"key":"B273","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.42.340"},{"key":"B274","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.2353"},{"key":"B275","doi-asserted-by":"publisher","DOI":"10.2337\/diab.37.7.857"},{"key":"B276","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90442-1"},{"key":"B277","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199404000-00037"},{"key":"B278","doi-asserted-by":"publisher","DOI":"10.1007\/BF00684859"},{"key":"B279","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.76.6.1063"},{"key":"B280","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197412052912301"},{"key":"B282","doi-asserted-by":"publisher","DOI":"10.1021\/bi9616615"},{"key":"B283","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1990.259.3.C439"},{"key":"B284","doi-asserted-by":"crossref","first-page":"784S","DOI":"10.1093\/jn\/125.suppl_3.784S","volume":"125","author":"PETERSON G.","year":"1995","journal-title":"J. Nutr."},{"key":"B285","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(95)03942-P"},{"key":"B286","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3835(94)03607-K"},{"key":"B287","doi-asserted-by":"publisher","DOI":"10.1126\/science.7716539"},{"key":"B288","first-page":"2119","volume":"13","author":"PIONTEK M.","year":"1993","journal-title":"Anticancer Res."},{"key":"B289","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)91032-N"},{"key":"B290","first-page":"213","volume":"66","author":"POPP R.","year":"1993","journal-title":"EXS"},{"key":"B291","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050168"},{"key":"B292","first-page":"124","volume":"106","author":"POWELL D. W.","year":"1994","journal-title":"Trans. Am. Clin. Climatol. Assoc."},{"key":"B293","doi-asserted-by":"publisher","DOI":"10.1007\/BF00373986"},{"key":"B295","doi-asserted-by":"publisher","DOI":"10.1159\/000199086"},{"key":"B296","first-page":"1210","volume":"23","author":"REDDY M. M.","year":"1987","journal-title":"Israel J. Med. Sci."},{"key":"B297","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.2.C474"},{"key":"B298","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.271.2.C650"},{"key":"B299","doi-asserted-by":"publisher","DOI":"10.1038\/369289a0"},{"key":"B300","doi-asserted-by":"publisher","DOI":"10.1038\/347358a0"},{"key":"B301","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1993.sp019578"},{"key":"B302","doi-asserted-by":"publisher","DOI":"10.1126\/science.2475911"},{"key":"B304","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1994.sp020335"},{"key":"B305","first-page":"G239","volume":"271","author":"ROMAN R. M.","year":"1996","journal-title":"Am. J. Physiol."},{"key":"B306","doi-asserted-by":"publisher","DOI":"10.1126\/science.2772657"},{"key":"B308","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233740"},{"key":"B309","doi-asserted-by":"publisher","DOI":"10.1016\/S0764-4469(97)86930-2"},{"key":"B310","doi-asserted-by":"publisher","DOI":"10.1021\/jm00253a010"},{"key":"B311","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(92)90684-B"},{"key":"B312","first-page":"G846","volume":"266","author":"SAHI J.","year":"1994","journal-title":"Am. J. Physiol."},{"key":"B313","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199608)168:2<276::AID-JCP6>3.0.CO;2-M"},{"key":"B315","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.269.5.C1280"},{"key":"B316","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870646"},{"key":"B317","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90458-W"},{"key":"B318","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/127.2.263"},{"key":"B319","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/S0022-3565(25)39408-5","volume":"266","author":"SARGENT C. A.","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B320","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(87)90684-X"},{"key":"B321","doi-asserted-by":"crossref","first-page":"15840","DOI":"10.1016\/S0021-9258(18)47664-8","volume":"262","author":"SCHMID-ANTOMARCHI H.","year":"1987","journal-title":"J. Biol. Chem."},{"key":"B322","first-page":"205","volume":"10","author":"SCHULTZ B. D.","year":"1994","journal-title":"Pediatr. Pulmonol. Suppl."},{"key":"B323","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900058"},{"key":"B324","first-page":"L192","volume":"271","author":"SCHULTZ B. D.","year":"1996","journal-title":"Am. J. Physiol."},{"key":"B326","first-page":"35","volume":"104","author":"SCHULTZ B. D.","year":"1994","journal-title":"J. Gen. Physiol."},{"key":"B327","first-page":"235","volume":"14","author":"SCHULTZ B. D.","year":"1997","journal-title":"Pediatr. Pulmonol. Suppl."},{"key":"B328","first-page":"200","volume":"12","author":"SCHULTZ B. D.","year":"1995","journal-title":"Pediatr. Pulmonol. Suppl."},{"key":"B329","first-page":"258","volume":"13","author":"SCHULTZ B. D.","year":"1996","journal-title":"Pediatr. Pulmonol. Suppl."},{"key":"B331","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.273.6.C2080"},{"key":"B333","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.105.3.329"},{"key":"B333a","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.1.S145"},{"key":"B334","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.7.3879"},{"key":"B335","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(05)80011-X"},{"key":"B336","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1994.266.5.C1464"},{"key":"B337","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.5.1637"},{"key":"B338","first-page":"G874","volume":"269","author":"SEARS C. L.","year":"1995","journal-title":"Am. J. Physiol."},{"key":"B339","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1994.tb17041.x"},{"key":"B340","first-page":"L561","volume":"269","author":"SHEN B. Q.","year":"1995","journal-title":"Am. J. Physiol."},{"key":"B341","doi-asserted-by":"publisher","DOI":"10.1016\/0925-4439(95)00115-8"},{"key":"B342","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233948"},{"key":"B343","doi-asserted-by":"publisher","DOI":"10.1016\/0143-4004(95)90116-7"},{"key":"B344","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.1994.sp003808"},{"key":"B345","first-page":"1","volume":"23","author":"SHENOLIKAR S.","year":"1991","journal-title":"Adv. Second Messenger Phosphoprotein Res."},{"key":"B346","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.1997.333bh.x"},{"key":"B347","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.100.4.573"},{"key":"B348","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S0026-895X(25)09011-X","volume":"41","author":"SHIMADA S.","year":"1992","journal-title":"Mol. Pharmacol."},{"key":"B349","first-page":"617","volume":"29","author":"SHIMADA T.","year":"1997","journal-title":"Drug Metab. Disposition"},{"key":"B350","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1996.0877"},{"key":"B351","doi-asserted-by":"publisher","DOI":"10.1007\/BF01869522"},{"key":"B352","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15991.x"},{"key":"B353","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.261.1.C51"},{"key":"B354","first-page":"189","volume":"12","author":"SINGH A. K.","year":"1995","journal-title":"Pediatr. Pulmonol. Suppl."},{"key":"B356","first-page":"234","volume":"14","author":"SINGH A. K.","year":"1997","journal-title":"Pediatric Pulmonol."},{"key":"B357","first-page":"101","volume":"13","author":"SINGH A. K.","year":"1996","journal-title":"Pediatr. Pulmonol."},{"key":"B358","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1995.380"},{"key":"B360","first-page":"L690","volume":"272","author":"SINGH M.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B361","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/4.2.269"},{"key":"B362","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.21.9963"},{"key":"B363","doi-asserted-by":"publisher","DOI":"10.1007\/BF01870568"},{"key":"B364","first-page":"G44","volume":"250","author":"SMITH P. L.","year":"1986","journal-title":"Am. J. Physiol."},{"key":"B365","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1991.tb05559.x"},{"key":"B366","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(93)90455-6"},{"key":"B367","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(85)91761-9"},{"key":"B368","doi-asserted-by":"crossref","first-page":"713S","DOI":"10.1093\/jn\/125.3_Suppl.713S","volume":"125","author":"STEELE V. E.","year":"1995","journal-title":"J. Nutr."},{"key":"B370","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(85)90403-9"},{"key":"B371","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1994.267.5.C1442"},{"key":"B372","doi-asserted-by":"crossref","first-page":"20653","DOI":"10.1016\/S0021-9258(20)80774-1","volume":"268","author":"STUTTS M. J.","year":"1993","journal-title":"J. Biol. Chem."},{"key":"B373","doi-asserted-by":"crossref","first-page":"8667","DOI":"10.1016\/S0021-9258(17)37019-9","volume":"269","author":"STUTTS M. J.","year":"1994","journal-title":"J. Biol. Chem."},{"key":"B374","doi-asserted-by":"publisher","DOI":"10.1007\/BF00585111"},{"key":"B375","doi-asserted-by":"publisher","DOI":"10.1007\/BF02583514"},{"key":"B376","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1991.260.3.C664"},{"key":"B377","first-page":"L844","volume":"272","author":"SWEEZEY N. B.","year":"1997","journal-title":"Am. J. Physiol."},{"key":"B379","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90379-I"},{"key":"B380","doi-asserted-by":"publisher","DOI":"10.1038\/352628a0"},{"key":"B381","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(90)81257-O"},{"key":"B382","doi-asserted-by":"publisher","DOI":"10.1038\/366079a0"},{"key":"B383","doi-asserted-by":"publisher","DOI":"10.2170\/jjphysiol.46.491"},{"key":"B384","doi-asserted-by":"publisher","DOI":"10.1007\/s002329900049"},{"key":"B385","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.11.1733"},{"key":"B386","doi-asserted-by":"publisher","DOI":"10.1007\/BF00227891"},{"key":"B387","doi-asserted-by":"publisher","DOI":"10.1007\/BF00370571"},{"key":"B388","first-page":"S215","volume":"44","author":"TOMINAGA M.","year":"1994","journal-title":"Jpn. J. Physiol."},{"key":"B389","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.77.2.417"},{"key":"B390","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.11055"},{"key":"B391","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.3.C859"},{"key":"B392","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2146"},{"key":"B393","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.17.9200"},{"key":"B394","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/151.3_Pt_2.S47"},{"key":"B396","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1128\/JVI.70.1.165-171.1996","volume":"70","author":"TSUNG K.","year":"1996","journal-title":"J. Virol."},{"key":"B397","doi-asserted-by":"publisher","DOI":"10.1126\/science.7531365"},{"key":"B398","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1023"},{"key":"B399","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.7.7737459"},{"key":"B400","doi-asserted-by":"publisher","DOI":"10.1007\/BF00374869"},{"key":"B401","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.104.6.997"},{"key":"B402","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(95)00648-6"},{"key":"B403","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.269.3.C683"},{"key":"B404","doi-asserted-by":"publisher","DOI":"10.1007\/BF00538939"},{"key":"B405","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)90214-2"},{"key":"B407","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90296-1"},{"key":"B408","first-page":"230","volume":"14","author":"VENGLARIK C.","year":"1997","journal-title":"Pediatr. Pulmonol."},{"key":"B409","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(96)79839-9"},{"key":"B410","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.104.1.123"},{"key":"B411","doi-asserted-by":"publisher","DOI":"10.1007\/BF00233545"},{"key":"B412","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.81.3.421"},{"key":"B413","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1996.270.2.C663"},{"key":"B414","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.2.C667"},{"key":"B415","doi-asserted-by":"publisher","DOI":"10.1016\/0008-6363(96)00075-2"},{"key":"B416","doi-asserted-by":"publisher","DOI":"10.1007\/BF00584942"},{"key":"B417","first-page":"2473","volume":"43","author":"WARNOCK D. G.","year":"1984","journal-title":"Federation Proc."},{"key":"B418","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1995.269.6.C1385"},{"key":"B419","doi-asserted-by":"publisher","DOI":"10.1080\/01635589309514265"},{"key":"B420","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a058081"},{"key":"B421","doi-asserted-by":"publisher","DOI":"10.1007\/s004240050424"},{"key":"B423","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90353-R"},{"key":"B424","doi-asserted-by":"publisher","DOI":"10.1038\/scientificamerican1295-52"},{"key":"B425","doi-asserted-by":"publisher","DOI":"10.1042\/bj3110017"},{"key":"B426","doi-asserted-by":"publisher","DOI":"10.1172\/JCI112175"},{"key":"B427","doi-asserted-by":"crossref","first-page":"631S","DOI":"10.1093\/jn\/125.3_Suppl.631S","volume":"125","author":"WILCOX J. N.","year":"1995","journal-title":"J. Nutr."},{"key":"B428","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.107.1.103"},{"key":"B429","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1989.256.5.C1033"},{"key":"B430","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb16644.x"},{"key":"B431","first-page":"199","volume":"44","author":"WINE J. J.","year":"1994","journal-title":"Jpn. J. Physiol."},{"key":"B432","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(94)80930-0"},{"key":"B433","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.61.6.687"},{"key":"B434","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1996.sp021254"},{"key":"B435","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.18.11728"},{"key":"B436","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0022-3565(25)22798-7","volume":"271","author":"XU X.","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B437","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(96)00208-0"},{"key":"B438","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.81.1.101"},{"key":"B439","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.1997.272.1.C142"},{"key":"B440","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/2.8.1253"},{"key":"B441","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040860305"},{"key":"B442","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.ge.29.120195.004021"},{"key":"B443","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(95)02252-X"}],"container-title":["Physiological Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/physrev.1999.79.1.S109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,29]],"date-time":"2025-06-29T05:17:36Z","timestamp":1751174256000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/physrev.1999.79.1.S109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,1,1]]},"references-count":420,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,1,1]]}},"alternative-id":["10.1152\/physrev.1999.79.1.S109"],"URL":"https:\/\/doi.org\/10.1152\/physrev.1999.79.1.s109","relation":{},"ISSN":["0031-9333","1522-1210"],"issn-type":[{"value":"0031-9333","type":"print"},{"value":"1522-1210","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,1,1]]}}}