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Assessment of the electrochemical driving forces and of membrane conductances for transcellular and paracellular electrolyte movement, the characterization of several ATPases, patch-clamp investigation, and cloning of the K<jats:sup>+<\/jats:sup>channel have provided important insights into the role of pumps and channels in those tubule cells that regulate K<jats:sup>+<\/jats:sup>secretion and reabsorption. This review summarizes K<jats:sup>+<\/jats:sup>transport properties in the mammalian collecting duct. 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