{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T00:51:49Z","timestamp":1774313509775,"version":"3.50.1"},"reference-count":0,"publisher":"American Physiological Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["American Journal of Physiology-Cell Physiology"],"published-print":{"date-parts":[[1991,7,1]]},"abstract":"<jats:p> The adhesion of osteoclasts to the bone matrix is mandatory for bone resorption. Contact of the osteoclast with bone surface induces, in fact, cell polarization and organization of the resorbing apparatus, the so-called \u201cruffled border.\u201d Cell-matrix interaction in osteoclasts is a complex phenomenon resulting from formation of the \u201cclear zone,\u201d a cytoplasmic area presenting the adhering plasma membrane, or \u201csealing membrane.\u201d The sealing membrane surrounds the ruffled border and seals the resorbing compartment, namely the extracellular space in which bone resorption takes place. Adhesion at this level occurs via specialized discrete structures, the \u201cpodosomes.\u201d Podosomes present most of the protein commonly found in focal adhesions, but with a peculiar organization. They are dynamic elements suitable for regulation, according with the functional demand of the cell. Their assembly increases during bone resorption and is regulated by the cytosolic free calcium concentration and the activity of protein kinase C. <\/jats:p>","DOI":"10.1152\/ajpcell.1991.261.1.c1","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T12:40:39Z","timestamp":1514119239000},"page":"C1-C7","source":"Crossref","is-referenced-by-count":115,"title":["Clear zone in osteoclast function: role of podosomes in regulation of bone-resorbing activity"],"prefix":"10.1152","volume":"261","author":[{"given":"A.","family":"Teti","sequence":"first","affiliation":[{"name":"Istituto di Anatomia Umana Normale, University of Bari, Italy."}]},{"given":"P. C.","family":"Marchisio","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia Umana Normale, University of Bari, Italy."}]},{"given":"A. Z.","family":"Zallone","sequence":"additional","affiliation":[{"name":"Istituto di Anatomia Umana Normale, University of Bari, Italy."}]}],"member":"24","container-title":["American Journal of Physiology-Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.physiology.org\/doi\/pdf\/10.1152\/ajpcell.1991.261.1.C1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T19:46:00Z","timestamp":1718653560000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.physiology.org\/doi\/10.1152\/ajpcell.1991.261.1.C1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,7,1]]}},"alternative-id":["10.1152\/ajpcell.1991.261.1.C1"],"URL":"https:\/\/doi.org\/10.1152\/ajpcell.1991.261.1.c1","relation":{},"ISSN":["0363-6143","1522-1563"],"issn-type":[{"value":"0363-6143","type":"print"},{"value":"1522-1563","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,7,1]]}}}