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Changes in mucosal permeability (blood-to-lumen clearance of<jats:sup>51<\/jats:sup>Cr-EDTA), leukocyte infiltration (myeloperoxidase activity in the intestine and intravital microscopy in the cremaster muscle), and vascular permeability (tissue wet-to-dry weight ratio and FITC-albumin leakage) were measured as indexes of tissue dysfunction. In wild-type animals, intestinal I\/R induced a significant increase in mucosal permeability, leukocyte infiltration, and vascular permeability. Mast cell-deficient animals were completely protected from I\/R-induced mucosal dysfunction. However, skeletal muscle I\/R induced a significant increase in leukocyte infiltration, FITC-albumin leakage, and edema formation to the same degree in both wild-type and mast cell-deficient animals. These data suggest that mast cells may be important mediators of I\/R-induced mucosal and microvascular dysfunction in the intestine but not of microvascular dysfunction in skeletal muscle.<\/jats:p>","DOI":"10.1152\/ajpgi.1998.275.2.g212","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T09:38:29Z","timestamp":1514108309000},"page":"G212-G218","source":"Crossref","is-referenced-by-count":13,"title":["Postischemic inflammation: a role for mast cells in intestine but not in skeletal muscle"],"prefix":"10.1152","volume":"275","author":[{"given":"Samina","family":"Kanwar","sequence":"first","affiliation":[{"name":"Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1"}]},{"given":"Michael J.","family":"Hickey","sequence":"additional","affiliation":[{"name":"Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1"}]},{"given":"Paul","family":"Kubes","sequence":"additional","affiliation":[{"name":"Immunology Research Group, Department of Physiology and Biophysics, University of Calgary, Calgary, Alberta, Canada T2N 4N1"}]}],"member":"24","reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00918979"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1159\/000235364"},{"key":"B3","first-page":"174","volume":"35","author":"Boros M.","year":"1991","journal-title":"Circ. 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