{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:26:05Z","timestamp":1792614365392,"version":"4.5.0"},"reference-count":0,"publisher":"American Physiological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Applied Physiology"],"published-print":{"date-parts":[[1979,3,1]]},"abstract":"<jats:p>Hill's equation can be slightly modified to fit the standard human blood O2 dissociation curve to within plus or minus 0.0055 fractional saturation (S) from O less than S less than 1. Other modifications of Hill's equation may be used to compute Po2 (Torr) from S (Eq. 2), and the temperature coefficient of Po2 (Eq. 3). Variations of the Bohr coefficient with Po2 are given by Eq. 4. S = (((Po2(3) + 150 Po2)(-1) x 23,400) + 1)(-1) (1) In Po2 = 0.385 In (S-1 - 1)(-1) + 3.32 - (72 S)(-1) - 0.17(S6) (2) DELTA In Po2\/delta T = 0.058 ((0.243 X Po2\/100)(3.88) + 1)(-1) + 0.013 (3) delta In Po2\/delta pH = (Po2\/26.6)(0.184) - 2.2 (4) Procedures are described to determine Po2 and S of blood iteratively after extraction or addition of a defined amount of O2 and to compute P50 of blood from a single sample after measuring Po2, pH, and S.<\/jats:p>","DOI":"10.1152\/jappl.1979.46.3.599","type":"journal-article","created":{"date-parts":[[2017,12,24]],"date-time":"2017-12-24T19:54:46Z","timestamp":1514145286000},"page":"599-602","source":"Crossref","is-referenced-by-count":566,"title":["Simple, accurate equations for human blood O2 dissociation computations"],"prefix":"10.1152","volume":"46","author":[{"given":"J. W.","family":"Severinghaus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"24","container-title":["Journal of Applied Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.physiology.org\/doi\/pdf\/10.1152\/jappl.1979.46.3.599","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,8]],"date-time":"2019-09-08T23:40:34Z","timestamp":1567986034000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.physiology.org\/doi\/10.1152\/jappl.1979.46.3.599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1979,3,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1979,3,1]]}},"alternative-id":["10.1152\/jappl.1979.46.3.599"],"URL":"https:\/\/doi.org\/10.1152\/jappl.1979.46.3.599","relation":{},"ISSN":["8750-7587","1522-1601"],"issn-type":[{"value":"8750-7587","type":"print"},{"value":"1522-1601","type":"electronic"}],"subject":[],"published":{"date-parts":[[1979,3,1]]}}}