{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:02:23Z","timestamp":1723161743110},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":4017,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>This study investigated the effect of experimentally\u2010induced cholestasis in the rat on the structure and\nfunction of the zona fasciculata, the glucocorticoid secretory region of the adrenal cortex. Wistar\u2010Furth\nrats (200\u2010250g) were assigned to three groups: bile duct ligated (BDL), Sham operated (Sham) and\nunmodified normal control (NC). On day 14, serum bilirubin and liver histology were performed to\nconfirm cholestasis in BDL animals together with basal 24 hour 17\u2010hydroxycorti\u2010costeroid excretion,\nadrenal histology and zona fasciculata ultrastructure in all experimental groups. Following this\nlaparotomy, structural and functional studies were repeated on day 15 to evaluate the response of the gland\nto surgically induced stress. Basal 24 hr. 17\u2010hydroxycorticoid steroid excretion was elevated in BDL animals\n(26.9 \u00b13.2 \u03bc g\/24 hr) with respect to Sham (10.4 \u00b1 2.3) and NC groups (13.5 \u00b1 3.2) (p &lt;0.05). Adrenal\nhistology and ultrastructural studies demonstrated excessive accumulation of vesicles laden with\nglucocorticoid biogenic precursors. Following surgical stress 24 hr 17 OH corticosteroid excretion increased\nin all groups: BDL (31.0 \u00b1 3.0 \u03bcg\/24 hr) vs Sham (15.6 \u00b1 1.8) and NC (14.5 \u00b1 2.4) Moderate alterations\nin zona fasciculata architecture were seen following surgery in all groups. Cholestasis induces overactivity\nof the zona fasciculata of the adrenal cortex, and may modify the normal metabolic responses to surgical\nand other stresses.<\/jats:p>","DOI":"10.1155\/1989\/34079","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T09:19:26Z","timestamp":1189675166000},"page":"271-281","source":"Crossref","is-referenced-by-count":1,"title":["Structural and Functional Alterations in The Zona Fasciculata ofThe Rat Adrenal Cortex in Obstructive Jaundice"],"prefix":"10.1155","volume":"1","author":[{"given":"P. T.","family":"Roughneen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. M.","family":"Tallon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane Haley","family":"Russell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B. J.","family":"Rowlands","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,1]]},"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1989\/034079.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1989\/34079","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T16:23:21Z","timestamp":1723134201000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1989\/34079"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1155\/1989\/34079"],"URL":"https:\/\/doi.org\/10.1155\/1989\/34079","archive":["Portico"],"relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"type":"print","value":"0894-8569"},{"type":"electronic","value":"1607-8462"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}