{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:25:28Z","timestamp":1723163128040},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":4017,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:p>It is not known whether microcalculi possess structural differences compared with larger stones or\nwhether they represent simply an earlier stage in stone disease.<\/jats:p><jats:p>We carried out a controlled study on 10 patients affected by gallbladder cholesterol microlithiasis (CM).\nIn all patients, samples from all parts of the stones were studied by X\u2010ray diffraction and by infrared\nspectrophotometry. Bile analysis was carried out to determine cholesterol, phospholipid and total bile\nacid content. The cholesterol saturation indices (C.S.I.) were calculated. In all samples, bacterial bile\nculture was carried out. The results were compared with those of 10 patients who had undergone\ncholecystectomy for large cholesterol stones, and for 10 patients who had undergone abdominal surgery\nbut without biliary pathology. Patients in these latter groups were matched with the first according to sex\nand age.<\/jats:p><jats:p>Microcalculi proved to be layered (nucleus and external layer) in only 2 cases and larger stones in 9;\ncholesterol was seen to be the principal crystalline component in all cases. Traces of bilirubin were found\nin 7 CM and in the nuclei of 5 larger stones.<\/jats:p><jats:p>These results show that the structural composition of microcalculi is similar to that of the nucleus of\nlarger stones. No substantial differences exist, however, between the two groups of patients regarding the\nother parameters taken into consideration.<\/jats:p>","DOI":"10.1155\/1989\/80465","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T09:19:26Z","timestamp":1189675166000},"page":"283-295","source":"Crossref","is-referenced-by-count":2,"title":["Cholesterol Microlithiasis: Bacteriology, Gallbladder Bile and Stone Composition"],"prefix":"10.1155","volume":"1","author":[{"given":"Leopoldo","family":"Sarli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Gafa\u2032","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernesto","family":"Longinotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Carreras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Pietra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anacleto","family":"Peracchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Dotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simonetta","family":"Cavalier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1989,1]]},"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1989\/080465.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1989\/80465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T16:23:23Z","timestamp":1723134203000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1989\/80465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1155\/1989\/80465"],"URL":"https:\/\/doi.org\/10.1155\/1989\/80465","archive":["Portico"],"relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"type":"print","value":"0894-8569"},{"type":"electronic","value":"1607-8462"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}