{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:51:46Z","timestamp":1792637506121,"version":"4.5.0"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":3652,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["8710235"],"award-info":[{"award-number":["8710235"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:p>\n                    Class II major histocompatibility complex (MHC) antigens are expressed predominantly on B\nlymphocytes and macrophages of tadpoles of the South African clawed frog,\n                    <jats:italic>Xenopus laevis<\/jats:italic>\n                    ,\nas is the pattern in lymphocyte populations of most mammals. However, unlike most\nmammals, young postmetamorphic frogs show expression of class II MHC antigens on a\nhigh proportion of thymocytes and most peripheral T and B lymphocytes. Using the J\u2010strain\nof\n                    <jats:italic>Xenopus<\/jats:italic>\n                    and the anticlass II monoclonal antibody, 14A2, we have studied, by indirect\nimmunofluorescence, whether inhibition of metamorphosis would alter the pattern of\nexpression of class II antigens during ontogeny. In control animals, class II antigens were\nvirtually absent from thymic lymphocytes and peripheral T cells of normal untreated larvae,\nbut could be found in increasing numbers in both populations after metamorphosis (10\u201012\nweeks of age). In contrast, larvae, whose metamorphosis was inhibited by treatment with\nsodium perchlorate, had relatively few class II\n                    <jats:sup>+<\/jats:sup>\n                    thymic lymphocytes throughout the 6\u2010month\nperiod of study, and the proportion of class II\n                    <jats:sup>+<\/jats:sup>\n                    splenic lymphocytes was approximately\nequal to that of IgM\n                    <jats:sup>+<\/jats:sup>\n                    B lymphocytes. Thus, perchlorate\u2010treated animals retained the larval\npattern of class II epression, suggesting that emergence of class II\n                    <jats:sup>+<\/jats:sup>\n                    T cells is dependent on\nmetamorphosis.\n                  <\/jats:p>","DOI":"10.1155\/1990\/25197","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T03:46:09Z","timestamp":1213155969000},"page":"97-104","source":"Crossref","is-referenced-by-count":31,"title":["Expression of Class II Major Histocompatibility ComplexAntigens on Adult T Cells in\n                    <i>Xenopus<\/i>\n                    is Metamorphosis\u2010 Dependent"],"prefix":"10.1155","volume":"1","author":[{"given":"Louise A.","family":"Rollins-Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Blair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[1990,4,9]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1990\/025197.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1990\/25197","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T07:43:42Z","timestamp":1723103022000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1990\/25197"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,1]]}},"alternative-id":["10.1155\/1990\/25197"],"URL":"https:\/\/doi.org\/10.1155\/1990\/25197","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1]]}}}