{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:44:59Z","timestamp":1760982299592},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":3287,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:p>We examined the effect of prolonged bile duct obstruction, and subsequent biliary decompression, on\nbiochemical and metabolic parameters, using a reversible jaundice model in male Fischer 344 rats. The\nanimals were studied after biliary obstruction for varying periods (4 days, one week, and two weeks) and\nfollowing decompression. They were sacrificed one or two weeks following decompression. All the rats\nwere compared to sham operated, pair\u2010fed, controls. Obstructive jaundice rapidly increased bilirubin,\nliver enzymes, serum free fatty acid, and triglyceride levels. Glucose levels were significantly decreased\nin the jaundice rats compared to their pair\u2010fed controls. Only after two weeks of jaundice was significant\nhypoalbuminemia observed. Following decompression, all biochemical and metabolic values gradually\nreturned to normal levels, except for albumin. Hypoalbuminemia was not reversed within the two\u2010week\npost\u2010decompression period. The rats jaundiced for two weeks had significantly higher mortality,\ncompared to the other groups. We conclude that prolonged jaundice adversely affects the metabolic\ncapacity of the rats, with albumin concentration being markedly decreased, and that biliary decompression\ncould not reverse completely all the alterations seen with cholestasis, especially following two\nweeks of bile duct obstruction.<\/jats:p>","DOI":"10.1155\/1991\/27457","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T09:19:26Z","timestamp":1189675166000},"page":"35-48","source":"Crossref","is-referenced-by-count":17,"title":["Metabolic Alterations in Obstructive Jaundice: Effect of Duration of Jaundice and Bile\u2010Duct Decompression"],"prefix":"10.1155","volume":"5","author":[{"given":"R. N.","family":"Younes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. A.","family":"Vydelingum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Derooij","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Scognamiglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. C.","family":"Posner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. F.","family":"Brennan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,3,15]]},"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1991\/027457.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1991\/27457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:18:12Z","timestamp":1723069092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1991\/27457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,1]]}},"alternative-id":["10.1155\/1991\/27457"],"URL":"https:\/\/doi.org\/10.1155\/1991\/27457","archive":["Portico"],"relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"type":"print","value":"0894-8569"},{"type":"electronic","value":"1607-8462"}],"subject":[],"published":{"date-parts":[[1991,1]]}}}