{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:46:33Z","timestamp":1773920793911,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2922,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>To investigate the age\u2010dependent mechanism of susceptibility for chicken anemia virus\n(CAV) infection, we inoculated embryos and chickens of ages between day 9 of\nembryonic development and day 28 after hatching with CAV. Chicken embryos\ninoculated at days 9 and 11 of development showed no CAV\u2010infected cells in the\nthymus, nor in other lymphoid organs. Many CAV\u2010infected cells were detected in the\nthymic cortex of all chicken embryos inoculated at days 13 and 16 of development and\nof all chickens inoculated 1, 3, and 7 days after hatching. All embryos and chickens that\ncontained CAV\u2010infected cells in the thymus also contained CAV\u2010infected cells in the\nbone marrow, but not in the bursa of Fabricius or the spleen. In chickens inoculated at\ndays 14 and 21, only few CAV\u2010infected cells were detected in the thymus, whereas these\ncells were not detected in thymi of 28\u2010day\u2010old inoculated chickens. Depletion of the\nthymic cortex was only detected in chickens inoculated from day 16 of embryonic\ndevelopment till day 21 after hatching. Only hematocrit values of the chickens\ninoculated 1 and 3 days after hatching were below normal. The rationale for the\nsimultaneous susceptibility of cells of the T\u2010cell lineage and cells of the erythrocyte\nlineage is discussed. As far as the thymus is concerned, the absence of clinical and\nmicroscopical signs of CAV infection in older chickens and the inability of CAV to infect\nembryos at days 9 and 11 of embryonic development may be caused by a lack of\nsusceptible thymocytes. In view of the three waves of thymic precursor cells that\npopulate the thymus during ontogeny, as described by Le Douarin and colleagues, we\nhypothesize that CAV only infects thymocytes derived from the second wave of\nprecursor cells.<\/jats:p>","DOI":"10.1155\/1992\/52484","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:46:23Z","timestamp":1213170383000},"page":"123-129","source":"Crossref","is-referenced-by-count":25,"title":["Susceptibility of Thymocytes for Infection by ChickenAnemia Virus is Related to Pre\u2010 and PosthatchingDevelopment"],"prefix":"10.1155","volume":"2","author":[{"given":"Suzan H. M.","family":"Jeurissen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marga E.","family":"Janse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk J.","family":"van Roozelaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guus","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerben F.","family":"de Boer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,1]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1992\/052484.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1992\/52484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:10:22Z","timestamp":1723072222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1992\/52484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1155\/1992\/52484"],"URL":"https:\/\/doi.org\/10.1155\/1992\/52484","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"value":"2314-8861","type":"print"},{"value":"2314-7156","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}