{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T17:38:31Z","timestamp":1760204311221,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2922,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DCB 86-2751","T32HD7118"],"award-info":[{"award-number":["DCB 86-2751","T32HD7118"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DCB 86-2751","T32HD7118"],"award-info":[{"award-number":["DCB 86-2751","T32HD7118"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>We have \nexamined fetal thymic development in the trisomy 16 (Ts16) mouse, \nwhich is considered to be a model for human trisomy 21, or Down \nSyndrome. The Ts16 thymus contains 10 to 20% of the number of \nlymphocytes found in a normal thymus at a comparable stage. \nExpression of thymocyte differentiation markers (Thy\u20101, CD5, CD8, \nCD4, CD3, and HSA) is severely affected in Ts16 fetuses aged \n14\u201318 gestational days. When thymuses from 14\u2010day Ts16 mice were \ncultured <jats:italic>in vitro<\/jats:italic>, these markers eventually \nreached levels of expression comparable to those seen in normal \nthymuses in culture. On the other hand, expression of CD44 appears \nto be unaffected in Ts16 thymuses <jats:italic>in vivo<\/jats:italic>, but \ndeclines <jats:italic>in vitro<\/jats:italic> relative to normal thymuses. \nReconstitution of depleted thymic stroma with thymocytes showed \nevidence of defects in both developmental \ncompartments.<\/jats:p>","DOI":"10.1155\/1992\/72627","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:46:23Z","timestamp":1213170383000},"page":"215-226","source":"Crossref","is-referenced-by-count":4,"title":["Defects in Thymocyte Differentiation and Thymocyte\u2010 Stromal Interactions in the Trisomy 16 Mouse"],"prefix":"10.1155","volume":"2","author":[{"given":"Janet L.","family":"Ewart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Auerbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,1]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1992\/072627.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1992\/72627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:08:02Z","timestamp":1723064882000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1992\/72627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1155\/1992\/72627"],"URL":"https:\/\/doi.org\/10.1155\/1992\/72627","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}