{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T21:10:05Z","timestamp":1723065005538},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2922,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100007013","name":"F. Hoffmann-La Roche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007013","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:p>Twenty\u2010eight heavy\u2010chain variable (V<jats:sub>H<\/jats:sub>1) region genes and the immunoglobulin (IgM)\nheavy\u2010chain constant region of an isogenic <jats:italic>Xenopus<\/jats:italic> hybrid, X. <jats:italic>laevis<\/jats:italic>\/X, <jats:italic>gilli<\/jats:italic>, LG7, have\nbeen sequenced. The LG7 clone represents the first <jats:italic>Xenopus<\/jats:italic> hybrid that is homozygous\nfor the IgH locus. The V<jats:sub>H<\/jats:sub>1 family was specifically investigated because V<jats:sub>H<\/jats:sub>1 genes are\nused by the antibodies produced during the <jats:italic>Xenopus<\/jats:italic> antidinitrophenol (DNP) response,\nThese V<jats:sub>H<\/jats:sub>1 germ\u2010line sequences establish a so\u2010called \u201ddictionary\u2014 that is available for\nstudying somatic hypermutational mechanisms in immunized frogs.<\/jats:p>","DOI":"10.1155\/1992\/74187","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:49:00Z","timestamp":1213170540000},"page":"13-24","source":"Crossref","is-referenced-by-count":10,"title":["Sequences of C<i>\u03bc<\/i> and the V<sub>H<\/sub>1 Family in LG7, a Clonable Strain of <i>Xenopus<\/i>, Homozygous for the Immunoglobulin Loci"],"prefix":"10.1155","volume":"3","author":[{"given":"Melanie","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Marcuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mich\u00e9le","family":"Courtet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louis","family":"Du Pasquier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,7,10]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1992\/074187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1992\/74187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:41:07Z","timestamp":1723063267000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1992\/74187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1155\/1992\/74187"],"URL":"https:\/\/doi.org\/10.1155\/1992\/74187","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}