{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T14:40:06Z","timestamp":1723128006902},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2669,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>Administration of 98% ethanol destroys tissues by coagulative necrosis. In the rat bearing 1,2\u2010dimethylhydrazine\u2010induced colonic carcinoma which has spread to the liver, direct injection of 0.1\u20130.2\nml ethanol into each of the hepatic metastases at the time of total colectomy afforded a significant\nsurvival advantage relative to colectomy alone (20.1 \u00b1 0.2 vs 12.8 \u00b1 0.2 months of age, mean \u00b1 SEM,\n<jats:italic>n<\/jats:italic> = 20, <jats:italic>p<\/jats:italic> &lt; 0.01 by the Mann\u2010Whitney U test). A pilot study was, therefore, carried out (2 women and 4 men, age range 43 to 71 years\u2014mean 56) to examine the clinical significance of these observations in\npatients with multiple hepatic metastases from carcinoma of the sigmoid colon. The tumour was\nresected then all palpable hepatic secondaries were injected with 1\u20131.5 ml of 98% ethanol. Two weeks\npost\u2010operatively and thereafter once every two months any hepatic lesions detected ultrasonically were\nsimilarly treated percutaneously. All the patients tolerated this treatment without any observed distress\nor adverse effects. Their mean survival measured from the time of tumour resection until death from any\ncause was 20 months (range 17 to 26 months). The survival gain afforded by chemonecrosis in addition\nto its simplicity and safety deserves further consideration to assess the exact role of this method in the\ntreatment of liver metastases from colonic cancer.<\/jats:p>","DOI":"10.1155\/1993\/45467","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T09:19:26Z","timestamp":1189675166000},"page":"33-41","source":"Crossref","is-referenced-by-count":0,"title":["Pilot Study on Alcohol\u2010Induced Chemonecrosis of Hepatic Metastases From Colonic Cancer"],"prefix":"10.1155","volume":"7","author":[{"given":"Aws S.","family":"Salim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1992,9,10]]},"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1993\/045467.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/hpb\/1993\/045467.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1993\/45467","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T14:15:25Z","timestamp":1723126525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1993\/45467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,9,10]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1155\/1993\/45467"],"URL":"https:\/\/doi.org\/10.1155\/1993\/45467","archive":["Portico"],"relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"type":"print","value":"0894-8569"},{"type":"electronic","value":"1607-8462"}],"subject":[],"published":{"date-parts":[[1992,9,10]]}}}