{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:28:15Z","timestamp":1761290895598,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2556,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/501100004817","name":"Medical Faculty, Lund University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004817","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004722","name":"Lars Hierta Memorial Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004722","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:p>Patients with obstructive jaundice are prone to septic complications after biliary tract operations.\nRestoring bile flow to the intestine may help to decrease the complication rate. The present study is\naimed at evaluating the effect of biliary decompression on bacterial translocation in jaundiced rats.<\/jats:p><jats:p>Sixty\u2010six male Sprague\u2010Dawley rats were randomly allocated to six groups subjected to common bile\nduct ligation (CBDL) and transection (groups 2\u20136) or sham operation (group 1). In groups and 2 the\nincidence of enteric bacterial translocation was determined 2 weeks after sham operation or CBDL. In\ngroups 3\u20136, biliary decompression was achieved by performing a choledochoduodenostomy after 2\nweeks of biliary decompression. Bacterial translocation was then studied 1,2,3 and 5 weeks following\nbiliary decompression.<\/jats:p><jats:p>The rate of bacterial translocation to mesenteric lymph nodes in obstructive jaundice was significantly\nhigher as compared with controls, and decreased with time to nil three weeks following biliary\ndecompression. The incidence of bacterial translocation was closely correlated (<jats:italic>r<\/jats:italic> = 0.844; <jats:italic>p<\/jats:italic> = 0.034) with serum alkaline phosphatase activity and seemed to fit with the morphological changes noted in the\nsmall intestine. The decrease in bacterial translocation, however, lags behind the recovery of liver\nfunction as measured by routine liver function tests and antipyrine clearance.<\/jats:p><jats:p>Obstructive jaundice thus promotes bacterial translocation in the rat. Biliary decompression gradually\ndecreases the rate of bacterial translocation.<\/jats:p>","DOI":"10.1155\/1993\/69283","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T09:19:26Z","timestamp":1189675166000},"page":"99-110","source":"Crossref","is-referenced-by-count":15,"title":["The Effect of Biliary Decompression on Bacterial Translocation in Jaundiced Rats"],"prefix":"10.1155","volume":"7","author":[{"given":"Jin Wen","family":"Ding","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasile","family":"Soltesz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roger","family":"Will\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Loft","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik E.","family":"Poulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e5kan","family":"P\u00e4rsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjell","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Bengmark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,1]]},"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1993\/069283.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1993\/69283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T22:35:13Z","timestamp":1723070113000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1993\/69283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1155\/1993\/69283"],"URL":"https:\/\/doi.org\/10.1155\/1993\/69283","archive":["Portico"],"relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"type":"print","value":"0894-8569"},{"type":"electronic","value":"1607-8462"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}