{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:10:03Z","timestamp":1723061403463},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2191,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>A multicentre trial was conducted to evaluate a new test for anti\u2010gliadin antibodies (AGA) in serum (Coeliac Screening Kit, CSK, Medical Innovations Limited, Artarmon, NSW, Australia). The te st showed excellent reproducibility for both anti\u2010gliadin IgA and IgG detection. The average intraassay coefficient of variation (CV) was 3.0% for IgA and 2.4% for IgG (n=6), while the\naverage interassay CV was 6.4% for IgA and 4.3% for IgG (n=3). By defining a positive te st as both IgA and IgG elevated, a sensitivity of 93% in untreated coeliacs (n=75) was observed. The corresponding specificities in healthy adults (n=130) and healthy children (n=77) were &gt;99% and 100% respectively, while in patients with other gastrointestinal disorders (disease controls) the specificity was 94% (n=129). The test was also useful in monitoring patients, with anti\u2010gliadin IgA and IgG falling for up to a year after commencing a gluten\u2010free diet (GFD) (12 adults). In some patients however, antibody levels did not reach the normal cutpoint after many months on a GFD, which may reflect the patients \u2032 poor adherence to their gluten free diet. The test was superior to the Pharmacia anti\u2010gliadin ELISA, and should be useful as an aid to the diagnosis of coeliac disease, as well as in the follow\u2010up of treated patients.<\/jats:p>","DOI":"10.1155\/1994\/285298","type":"journal-article","created":{"date-parts":[[2015,2,24]],"date-time":"2015-02-24T21:01:37Z","timestamp":1424811697000},"page":"71-80","source":"Crossref","is-referenced-by-count":4,"title":["Screening and Monitoring Coeliac Disease: Multicentre Trial of a New Serum Antibody Test Kit"],"prefix":"10.1155","volume":"12","author":[{"given":"Peter L.","family":"Devine","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey W.","family":"Birrells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey P.","family":"Golder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N.","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shethah","family":"Morgan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Gillis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hobson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross","family":"Whybint","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John H.","family":"Skerritt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,1]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/1994\/285298.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1994\/285298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T19:20:51Z","timestamp":1723058451000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1994\/285298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1155\/1994\/285298"],"URL":"https:\/\/doi.org\/10.1155\/1994\/285298","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"type":"print","value":"0278-0240"},{"type":"electronic","value":"1875-8630"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}