{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:24:32Z","timestamp":1740173072534,"version":"3.37.3"},"reference-count":0,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2298,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AI-07840-02"],"award-info":[{"award-number":["AI-07840-02"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>A rat IgM monoclonal antibody, PA3\u2010795, inhibits the antigen\u2010specific responses of mouse\nT\u2010cell hybridomas. It recognizes a heavily glycosylated cell\u2010surface protein, designated\nLgp55, that is detectable after activation on mature T cells. During fetal life, Lgp55 is found\nat high levels on newly immigrant thymic T\u2010cell precursors prior to surface expression of\nother T\u2010lineage molecules. High levels of expression are also found on thymocytes in the\nouter cortex of adult mice. Thymocytes at later stages of differentiation bear decreasing\namounts of surface Lgp55, and none is detectable on \u201csingle\u2010positive\u201d thymocytes in the\nthymic medulla or on resting mature T cells from the periphery. Addition of monoclonal\nanti\u2010Lgp55 to fetal thymus organ culture decreases the output of \u201cmature\u201d CD4 singlepositive\nthymocytes when it is begun before fetal day 13.5. These findings suggest that\nLgp55 contributes to cell\u2010cell interactions that regulate very early steps in T\u2010cell development\nin the mouse.<\/jats:p>","DOI":"10.1155\/1994\/29157","type":"journal-article","created":{"date-parts":[[2008,6,11]],"date-time":"2008-06-11T07:49:00Z","timestamp":1213170540000},"page":"257-263","source":"Crossref","is-referenced-by-count":2,"title":["The Accessory Molecule Lgp55 Plays a Role Early in Murine Fetal Thymocyte Differentiation"],"prefix":"10.1155","volume":"3","author":[{"given":"Marcia","family":"Mcduffie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William T.","family":"Golde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,9,16]]},"container-title":["Journal of Immunology Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/jir\/1994\/029157.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1994\/29157","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T20:38:06Z","timestamp":1723063086000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1994\/29157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,9,16]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1155\/1994\/29157"],"URL":"https:\/\/doi.org\/10.1155\/1994\/29157","archive":["Portico"],"relation":{},"ISSN":["2314-8861","2314-7156"],"issn-type":[{"type":"print","value":"2314-8861"},{"type":"electronic","value":"2314-7156"}],"subject":[],"published":{"date-parts":[[1993,9,16]]}}}