{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:03:55Z","timestamp":1723161835556},"reference-count":0,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":2443,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["HPB Surgery"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:p>Although continuous hepatic artery infusions (CHAI) of (FUDR) Floxuridine have been effective in\nreducing the size of colorectal hepatic metastases the toxicity of the infusions have been high with almost\na quarter of the patients developing biliary sclerosis. Techniques to lower toxicity, yet continue the\nbeneficial antitumor effects, are being investigated. One suggested strategy is to change the flow pattern\nof the continuous infusion from a constant rate to a day cycled pattern. In this infusion a continuous rate\nis given over a 24 hour period with 60% of the infusion delivered between 3 PM and 9 PM and the least\namount of infusion delivered between 3 AM and 9 PM. Previous research has suggested that this day\ncycle pattern will lower the toxicity of the infusion. This experiment is a test of \u201cday cycled\u201d continuous\nhepatic artery infusions in rats bearing hepatic metastases from a colon adenocarcinoma. Previous\nresearch from our laboratory has shown a lowered toxicity when the constant infusion was replaced with\nthe day cycled pattern.<\/jats:p><jats:p>In the present study 10 rats with hepatic adenocarcinoma metastases were placed on constant CHAI\nof FUDR at 10mg\/kg\/day for 14 days. There was an 80% mortality from chemotherapy toxicity and a\n90% objective response rate. Nine other rats were treated with \u201cday cycled\u201d CHAI of FUDR at 15mg\/kg\/d. There was no mortality in this group and the objective response rate was 90% as in the previous\ngroup. This study demonstrated that \u201cday cycled\u201d CHAI of FUDR was substantially less toxic and that\nthe antitumor effect was identical to the constant infusion.<\/jats:p>","DOI":"10.1155\/1994\/54058","type":"journal-article","created":{"date-parts":[[2007,9,13]],"date-time":"2007-09-13T09:19:26Z","timestamp":1189675166000},"page":"219-224","source":"Crossref","is-referenced-by-count":7,"title":["The Effects on Liver Metastases of Circadian Patterned Continuous Hepatic Artery Infusion of FUDR"],"prefix":"10.1155","volume":"7","author":[{"given":"M. Margaret","family":"Kemeny","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galo","family":"Alava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge M.","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1993,4,24]]},"container-title":["HPB Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/archive\/1994\/054058.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1994\/54058","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T02:06:52Z","timestamp":1723082812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1994\/54058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,4,24]]},"references-count":0,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1155\/1994\/54058"],"URL":"https:\/\/doi.org\/10.1155\/1994\/54058","archive":["Portico"],"relation":{},"ISSN":["0894-8569","1607-8462"],"issn-type":[{"type":"print","value":"0894-8569"},{"type":"electronic","value":"1607-8462"}],"subject":[],"published":{"date-parts":[[1993,4,24]]}}}