{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T05:06:12Z","timestamp":1735707972687,"version":"3.32.0"},"reference-count":0,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1826,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bristol\u2013Myers Squibb"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>To compare the activity of cefepime, a fourth\u2010generation cephalosporin, with several available antimicrobials, in vitro susceptibility studies were carried out on bacteria commonly associated with various infections, including sepsis. Ten tertiary care hospital laboratories in six provinces provided 1276 clinically relevant isolates of aerobic Gram\u2010negative bacilli and Gram\u2010positive cocci during 1993. When the activity of each of the antimicrobials was determined against all isolates submitted, cefepime, piperacillin\/tazobactam, imipenem and ciprofloxacin all had minimal inhibitory concentrations for 90% of the organisms (<jats:sc>mic<\/jats:sc><jats:sub>90<\/jats:sub>) two or more dilutions below the <jats:sc>mic<\/jats:sc> resistant category. Gentamicin\u2019s <jats:sc>mic<\/jats:sc><jats:sub>90<\/jats:sub> against all organisms tested was one dilution below the <jats:sc>mic<\/jats:sc> resistant category. The <jats:sc>mic<\/jats:sc><jats:sub>90<\/jats:sub>s of the third\u2010generation cephalosporins, piperacillin and ticarcillin\/clavulanate, for <jats:italic>Enterobacter<\/jats:italic> species fell in the resistant category. This is presumably due to constitutive high level chromosomal cephalosporinase production. The <jats:sc>mic<\/jats:sc><jats:sub>90<\/jats:sub>s of cefepime for <jats:italic>Enterobacter<\/jats:italic> species was three or more dilutions below the <jats:sc>mic<\/jats:sc> resistant category. The <jats:sc>mic<\/jats:sc><jats:sub>90<\/jats:sub>s of all antimcrobials against <jats:italic>Staphylococcus aureus<\/jats:italic>, with the exception of ceftazidime and piperacillin, had <jats:sc>mic<\/jats:sc><jats:sub>90<\/jats:sub> categories two or more dilutions below the resistant category. The activity of cefepime, piperacillin\/tazobactam, imipenem, ciprofloxacin and gentamicin make them excellent candidates for the empirical therapy of serious infections due to aerobic Gram\u2010negative bacilli and <jats:italic>S aureus<\/jats:italic>.<\/jats:p>","DOI":"10.1155\/1995\/458762","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T13:08:37Z","timestamp":1458047317000},"page":"258-262","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Activity of Cefepime with Several Antimicrobials against Aerobic Gram\u2010Negative and Gram\u2010Positive Organisms Isolated from Patients across Canada in 1993"],"prefix":"10.1155","volume":"6","author":[{"given":"Donald E","family":"Low","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"The Canadian Antimicrobial Resistance Study Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1995,1]]},"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/1995\/458762.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1995\/458762","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,31]],"date-time":"2024-12-31T05:01:17Z","timestamp":1735621277000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1995\/458762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1155\/1995\/458762"],"URL":"https:\/\/doi.org\/10.1155\/1995\/458762","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"type":"print","value":"1712-9532"},{"type":"electronic","value":"1918-1493"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}