{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T16:10:13Z","timestamp":1722355813412},"reference-count":0,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1856,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:p>Objective: To report in vitro susceptibilities of penicillin\u2010susceptible and penicillin\u2010intermediate <jats:italic>Streptococcus pneumoniae<\/jats:italic> isolates to cephalosporins, vancomycin and teicoplanin.<\/jats:p><jats:p>Design: Minimal inhibitory concentrations (<jats:sc>mic<\/jats:sc>) were determined according to National Committee for Clinical Laboratory Standards guidelines for 17 penicillin\u2010susceptible isolates (<jats:sc>mic<\/jats:sc> 0.06 mg\/L or less) and 16 isolates showing intermediate susceptibility to penicillin (<jats:sc>mic<\/jats:sc> 0.12 to 1.0 mg\/L).<\/jats:p><jats:p>Setting: Tertiary care university centre.<\/jats:p><jats:p>Main Results: Comparison of the <jats:sc>mic<jats:sub>90<\/jats:sub><\/jats:sc> values with those of other antibiotics tested demonstrated that ceftriaxone, cefotaxime and teicoplanin were the most active agents against penicillin\u2010susceptible strains. However, teicoplanin had the lowest <jats:sc>mic<\/jats:sc> and was superior to other agents against strains with intermediate penicillin susceptibility. The <jats:sc>mic<\/jats:sc>s of all cephalosporins increased in concordance with the <jats:sc>mic<\/jats:sc> of penicillin.<\/jats:p><jats:p>Conclusion: Isolates demonstrating intermediate susceptibility or resistance to penicillin should be routinely evaluated for susceptibility to clinically important cephalosporins.<\/jats:p>","DOI":"10.1155\/1995\/725654","type":"journal-article","created":{"date-parts":[[2016,3,15]],"date-time":"2016-03-15T08:03:35Z","timestamp":1458029015000},"page":"83-87","source":"Crossref","is-referenced-by-count":0,"title":["Activity of Vancomycin, Teicoplanin and Cephalosporins against Penicillin\u2010Susceptible and Penicillin\u2010Intermediate <i>Streptococcus Pneumoniae<\/i>"],"prefix":"10.1155","volume":"6","author":[{"given":"Vivian G","family":"Loo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Lavall\u00e9e","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"McAlear","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh G","family":"Robson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1994,12,2]]},"container-title":["Canadian Journal of Infectious Diseases and Medical Microbiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cjidmm\/1995\/725654.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1995\/725654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T15:30:55Z","timestamp":1722353455000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1995\/725654"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,12,2]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1155\/1995\/725654"],"URL":"https:\/\/doi.org\/10.1155\/1995\/725654","archive":["Portico"],"relation":{},"ISSN":["1712-9532","1918-1493"],"issn-type":[{"type":"print","value":"1712-9532"},{"type":"electronic","value":"1918-1493"}],"subject":[],"published":{"date-parts":[[1994,12,2]]}}}