{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T03:47:34Z","timestamp":1752551254423},"reference-count":0,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":1461,"URL":"http:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[1996,1]]},"abstract":"<jats:p>Our ai m was to ascertai n the degree of variation of serum soluble vascular cell adhesion moleculeI (VCAM\u20101) concentrations according to the nature and the severity of an underl ying liver disease . One\u2010hundred forty sera collected from 123 patients (83 male, 40 female) with acute hepatitis (n=14). mi Id chronic Ii ver disease (n=52) or cirrhosis (n=57) of different etiologies as well as from 17 healthy blood donors (8 male, 9 female) were studied. Soluble VCAM\u2010I concentration was measured immunoenzymatically. One\u2010way analysis of variance revealed a significant variability of the mean values of soluble VCAM\u20101 among groups (F=80.02, p &lt;0.000 I). All groups of patients had higher soluble VCAM\u2010I than controls; moreover, patients with acute hepatitis and patients with cirrhosis had higher soluble VCAM\u20101 levels than patients with mild chronic liver disease (Bonferroni\u2032s test. p &lt;0.(1). These results did not change after stratification of patients according to the etiology (viral or toxic) of liver disease (two\u2010way analysis of variance: grouping factor diagnosis, F=60.39, p &lt;0.000 I; grouping factor etiology. F= 1.73, p NS). Cholinesterase, total bilirubin, circulating thrombocytes and blood urea nitrogen were the independent predictors of the concentration of soluble VCAM\u20101. In conclusion, patients with liver disease have high serum soluble VCAM\u20101, which seems to reflect more the severity of impairment of liver function rather than the etiologic nature of the disease.<\/jats:p>","DOI":"10.1155\/1996\/129325","type":"journal-article","created":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T21:03:13Z","timestamp":1424898193000},"page":"11-17","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Serum Soluble Vascular\u2010Cell Adhesion Molecule\u20101 (VCAM\u20101) in Patients with Acute and Chronic Liver Diseases"],"prefix":"10.1155","volume":"13","author":[{"given":"Mario","family":"Pirisi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Fabris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edmondo","family":"Falleti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Soardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierluigi","family":"Toniutto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Vitulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabio","family":"Gonano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ettore","family":"Bartoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1996,1]]},"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/1996\/129325.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/1996\/129325","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,8]],"date-time":"2024-08-08T13:25:51Z","timestamp":1723123551000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/1996\/129325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1996,1]]}},"alternative-id":["10.1155\/1996\/129325"],"URL":"https:\/\/doi.org\/10.1155\/1996\/129325","archive":["Portico"],"relation":{},"ISSN":["0278-0240","1875-8630"],"issn-type":[{"type":"print","value":"0278-0240"},{"type":"electronic","value":"1875-8630"}],"subject":[],"published":{"date-parts":[[1996,1]]},"assertion":[{"value":"1996-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"1996-01-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}